Performance of Routine Helicobacter pylori Invasive Tests in Patients with Dyspepsia
Background. This study was designed to compare the accuracy of three different invasive methods for the detection of Helicobacter pylori (H. pylori) infection in patients with dyspepsia. These tests included culture, histology, and the rapid urease test (CLO test). Methods. H. pylori infection was d...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2013/184806 |
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| author | Hsi-Chang Lee Ting-Chang Huang Chin-Lin Lin Kuan-Yang Chen Chung-Kwe Wang Deng-Chyang Wu |
| author_facet | Hsi-Chang Lee Ting-Chang Huang Chin-Lin Lin Kuan-Yang Chen Chung-Kwe Wang Deng-Chyang Wu |
| author_sort | Hsi-Chang Lee |
| collection | DOAJ |
| description | Background. This study was designed to compare the accuracy of three different invasive methods for the detection of Helicobacter pylori (H. pylori) infection in patients with dyspepsia. These tests included culture, histology, and the rapid urease test (CLO test). Methods. H. pylori infection was diagnosed prospectively in 246 untreated dyspeptic patients who underwent upper gastrointestinal endoscopy. The gold standard for H. pylori infection was based on a positive culture or both a positive histological examination and a CLO test. Results. H. pylori was diagnosed in 33.3% of the patients. The sensitivity, specificity, positive predictive value, negative predictive value, and overall accuracy were as follows: histology from the antrum (95.12; 95.12; 90.7; 97.5; 95.12%); histology from the antrum and corpus (95.12; 95.12; 90.7; 97.5; 95.12%); histology from the corpus (76.83; 96.95; 92.65; 89.33; 90.24%); culture (91.46; 100; 100; 95.91; 97.15%); a CLO test from the antrum and corpus (85.59; 100; 100; 93.71; 95.52%); a CLO test from the antrum (64.63; 100; 100; 84.97; 88.21%); a CLO test from the corpus (69.51; 100; 100; 96.77; 89.83%), respectively. Conclusions. Antral biopsy histology and culture are the best methods for the diagnosis of H. pylori infection in our cohort of patients with dyspepsia. |
| format | Article |
| id | doaj-art-a2af6b6eec2042ef888be29c49c4edc6 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-a2af6b6eec2042ef888be29c49c4edc62025-02-03T05:52:15ZengWileyGastroenterology Research and Practice1687-61211687-630X2013-01-01201310.1155/2013/184806184806Performance of Routine Helicobacter pylori Invasive Tests in Patients with DyspepsiaHsi-Chang Lee0Ting-Chang Huang1Chin-Lin Lin2Kuan-Yang Chen3Chung-Kwe Wang4Deng-Chyang Wu5Liver Center, Department of Gastroenterology, Ren-Ai Branch, Taipei City Hospital, Taipei 106, TaiwanLiver Center, Department of Gastroenterology, Ren-Ai Branch, Taipei City Hospital, Taipei 106, TaiwanLiver Center, Department of Gastroenterology, Ren-Ai Branch, Taipei City Hospital, Taipei 106, TaiwanLiver Center, Department of Gastroenterology, Ren-Ai Branch, Taipei City Hospital, Taipei 106, TaiwanLiver Center, Department of Gastroenterology, Ren-Ai Branch, Taipei City Hospital, Taipei 106, TaiwanDivision of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, TaiwanBackground. This study was designed to compare the accuracy of three different invasive methods for the detection of Helicobacter pylori (H. pylori) infection in patients with dyspepsia. These tests included culture, histology, and the rapid urease test (CLO test). Methods. H. pylori infection was diagnosed prospectively in 246 untreated dyspeptic patients who underwent upper gastrointestinal endoscopy. The gold standard for H. pylori infection was based on a positive culture or both a positive histological examination and a CLO test. Results. H. pylori was diagnosed in 33.3% of the patients. The sensitivity, specificity, positive predictive value, negative predictive value, and overall accuracy were as follows: histology from the antrum (95.12; 95.12; 90.7; 97.5; 95.12%); histology from the antrum and corpus (95.12; 95.12; 90.7; 97.5; 95.12%); histology from the corpus (76.83; 96.95; 92.65; 89.33; 90.24%); culture (91.46; 100; 100; 95.91; 97.15%); a CLO test from the antrum and corpus (85.59; 100; 100; 93.71; 95.52%); a CLO test from the antrum (64.63; 100; 100; 84.97; 88.21%); a CLO test from the corpus (69.51; 100; 100; 96.77; 89.83%), respectively. Conclusions. Antral biopsy histology and culture are the best methods for the diagnosis of H. pylori infection in our cohort of patients with dyspepsia.http://dx.doi.org/10.1155/2013/184806 |
| spellingShingle | Hsi-Chang Lee Ting-Chang Huang Chin-Lin Lin Kuan-Yang Chen Chung-Kwe Wang Deng-Chyang Wu Performance of Routine Helicobacter pylori Invasive Tests in Patients with Dyspepsia Gastroenterology Research and Practice |
| title | Performance of Routine Helicobacter pylori Invasive Tests in Patients with Dyspepsia |
| title_full | Performance of Routine Helicobacter pylori Invasive Tests in Patients with Dyspepsia |
| title_fullStr | Performance of Routine Helicobacter pylori Invasive Tests in Patients with Dyspepsia |
| title_full_unstemmed | Performance of Routine Helicobacter pylori Invasive Tests in Patients with Dyspepsia |
| title_short | Performance of Routine Helicobacter pylori Invasive Tests in Patients with Dyspepsia |
| title_sort | performance of routine helicobacter pylori invasive tests in patients with dyspepsia |
| url | http://dx.doi.org/10.1155/2013/184806 |
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