Carfilzomib promotes Iodine-125 seed radiation-induced apoptosis, paraptosis, and ferroptosis in esophageal squamous cell carcinoma by aggravating endoplasmic reticulum stress

Carfilzomib promotes Iodine-125 seed radiation-induced apoptosis, paraptosis, and ferroptosis in esophageal squamous cell carcinoma by aggravating endoplasmic reticulum stress

Iodine-125 (125I) seed brachytherapy has been applied to treat various malignant tumors such as esophageal cancer, however, radioresistance can reduce its efficacy. Endoplasmic reticulum stress (ERS) and subsequent unfolded protein response (UPR) is one of the core mechanisms of 125I seed radiation-...

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Bibliographic Details
Main Authors: Chao Wang, Yin-Lin Zha, Hao Wang, Bai Sun, Wei-Guang Qiang, Ye Yuan, Hong-Bing Shi, Wen-Wei Hu
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Translational Oncology
Subjects:
Iodine-125
Carfilzomib
Apoptosis
Ferroptosis
Esophageal cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S193652332500124X
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