DNA hypomethylation-mediated upregulation of GADD45B facilitates airway inflammation and epithelial cell senescence in COPD

DNA hypomethylation-mediated upregulation of GADD45B facilitates airway inflammation and epithelial cell senescence in COPD

Introduction: Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease typically characterized by chronic airway inflammation, with emerging evidence highlighting the driving role of cellular senescence-related lung aging. Accelerated lung aging and inflammation mutually reinforce eac...

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Bibliographic Details
Main Authors: Yuan Zhan, Qian Huang, Zhesong Deng, Shanshan Chen, Ruonan Yang, Jiaheng Zhang, Yating Zhang, Maocuo Peng, Jixing Wu, Yiya Gu, Zhilin Zeng, Jungang Xie
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Journal of Advanced Research
Subjects:
GADD45B
Inflammation
Cellular senescence
DNA methylation
Chronic obstructive pulmonary disease
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123224000675
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