Associations of blood-based biomarkers of neurodegenerative diseases with mortality, cardio- and cerebrovascular events in persons with chronic coronary syndrome
Background: In light of growing evidence highlighting interactions between cardiac and brain health, we investigated associations of biomarkers of neurodegenerative diseases with adverse outcomes (all-cause and cardiovascular mortality, major cardiovascular events, and stroke) in persons with chroni...
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Elsevier
2025-02-01
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| Series: | Experimental Gerontology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0531556525000129 |
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| author | Valerie Lohner Laura Perna Ben Schöttker Robert Perneczky Hermann Brenner Ute Mons |
| author_facet | Valerie Lohner Laura Perna Ben Schöttker Robert Perneczky Hermann Brenner Ute Mons |
| author_sort | Valerie Lohner |
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| description | Background: In light of growing evidence highlighting interactions between cardiac and brain health, we investigated associations of biomarkers of neurodegenerative diseases with adverse outcomes (all-cause and cardiovascular mortality, major cardiovascular events, and stroke) in persons with chronic coronary syndrome (CCS). Methods: We used data from a cohort of persons with CCS for whom major adverse events were recorded over a follow-up of 20 years. We measured biomarkers of neurodegenerative diseases in baseline blood samples, using the Single-Molecule Array Technology on a HD-1 Analyzer. These include biomarkers of neuronal (neurofilament light chain (NfL) (n = 379)) and glial neurodegeneration (glial fibrillary acidic protein (GFAP) (n = 379)), and Alzheimer's disease pathology (phosphorylated tau181 (n = 379), total tau (n = 377), and amyloid β (Aβ40, Aβ42, Aβ42/Aβ40) (n = 377)). We applied Cox-proportional hazards models to evaluate associations of these biomarkers with adverse outcomes, adjusting for covariates and exploring interactions with apolipoprotein E (ApoE) ε4 genotype. Results: Participants with higher NfL levels had increased rates of all-cause and cardiovascular mortality (Hazard ratio per increase by one standard deviation (95 % confidence interval): all-cause mortality: 1.36 (1.10–1.68); cardiovascular mortality: 1.42 (1.05–1.93)). The Aβ40/Aβ42-ratio was linked to incident stroke (0.72 (0.52–1.00)). Associations of GFAP with all-cause mortality and incident stroke were depending on ApoE ε4 genotype. The other biomarkers were not significantly associated with the studied outcomes. Conclusions: In persons with CSS, NfL and the Aβ40/Aβ42-ratio were related to mortality and incident stroke, respectively, whereas associations of GFAP with adverse outcomes varied by ApoE genotype. These biomarkers might play a role in linking aging, cardiovascular and neurodegenerative diseases. |
| format | Article |
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| institution | Kabale University |
| issn | 1873-6815 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
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| series | Experimental Gerontology |
| spelling | doaj-art-a29e3077884c486bae7310b2e7f2a04a2025-01-31T05:10:09ZengElsevierExperimental Gerontology1873-68152025-02-01200112684Associations of blood-based biomarkers of neurodegenerative diseases with mortality, cardio- and cerebrovascular events in persons with chronic coronary syndromeValerie Lohner0Laura Perna1Ben Schöttker2Robert Perneczky3Hermann Brenner4Ute Mons5Cardiovascular Epidemiology of Aging, Department of Cardiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Germany; Corresponding authors at: Klinik III für Innere Medizin, Universitätsklinikum Köln (AöR), Kerpener Str. 62, 50937 Köln, Germany.Department Genes and Environment, Max Planck Institute of Psychiatry, Munich, Germany; Division of Mental Health of Older Adults, Department of Psychiatry and Psychotherapy, LMU Hospital, LMU Munich, GermanyDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Network Aging Research, Heidelberg University, Heidelberg, GermanyDivision of Mental Health of Older Adults, Department of Psychiatry and Psychotherapy, LMU Hospital, LMU Munich, Germany; Ageing Epidemiology (AGE) Research Unit, School of Public Health, Imperial College London, London, UK; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany; Sheffield Institute for Translational Neurology (SITraN), University of Sheffield, Sheffield, UKDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Network Aging Research, Heidelberg University, Heidelberg, GermanyCardiovascular Epidemiology of Aging, Department of Cardiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Germany; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Corresponding authors at: Klinik III für Innere Medizin, Universitätsklinikum Köln (AöR), Kerpener Str. 62, 50937 Köln, Germany.Background: In light of growing evidence highlighting interactions between cardiac and brain health, we investigated associations of biomarkers of neurodegenerative diseases with adverse outcomes (all-cause and cardiovascular mortality, major cardiovascular events, and stroke) in persons with chronic coronary syndrome (CCS). Methods: We used data from a cohort of persons with CCS for whom major adverse events were recorded over a follow-up of 20 years. We measured biomarkers of neurodegenerative diseases in baseline blood samples, using the Single-Molecule Array Technology on a HD-1 Analyzer. These include biomarkers of neuronal (neurofilament light chain (NfL) (n = 379)) and glial neurodegeneration (glial fibrillary acidic protein (GFAP) (n = 379)), and Alzheimer's disease pathology (phosphorylated tau181 (n = 379), total tau (n = 377), and amyloid β (Aβ40, Aβ42, Aβ42/Aβ40) (n = 377)). We applied Cox-proportional hazards models to evaluate associations of these biomarkers with adverse outcomes, adjusting for covariates and exploring interactions with apolipoprotein E (ApoE) ε4 genotype. Results: Participants with higher NfL levels had increased rates of all-cause and cardiovascular mortality (Hazard ratio per increase by one standard deviation (95 % confidence interval): all-cause mortality: 1.36 (1.10–1.68); cardiovascular mortality: 1.42 (1.05–1.93)). The Aβ40/Aβ42-ratio was linked to incident stroke (0.72 (0.52–1.00)). Associations of GFAP with all-cause mortality and incident stroke were depending on ApoE ε4 genotype. The other biomarkers were not significantly associated with the studied outcomes. Conclusions: In persons with CSS, NfL and the Aβ40/Aβ42-ratio were related to mortality and incident stroke, respectively, whereas associations of GFAP with adverse outcomes varied by ApoE genotype. These biomarkers might play a role in linking aging, cardiovascular and neurodegenerative diseases.http://www.sciencedirect.com/science/article/pii/S0531556525000129Blood-based biomarkers of neurodegenerative diseasesMortalityCoronary heart diseaseChronic coronary syndromeMajor cardiovascular eventsCerebrovascular events |
| spellingShingle | Valerie Lohner Laura Perna Ben Schöttker Robert Perneczky Hermann Brenner Ute Mons Associations of blood-based biomarkers of neurodegenerative diseases with mortality, cardio- and cerebrovascular events in persons with chronic coronary syndrome Experimental Gerontology Blood-based biomarkers of neurodegenerative diseases Mortality Coronary heart disease Chronic coronary syndrome Major cardiovascular events Cerebrovascular events |
| title | Associations of blood-based biomarkers of neurodegenerative diseases with mortality, cardio- and cerebrovascular events in persons with chronic coronary syndrome |
| title_full | Associations of blood-based biomarkers of neurodegenerative diseases with mortality, cardio- and cerebrovascular events in persons with chronic coronary syndrome |
| title_fullStr | Associations of blood-based biomarkers of neurodegenerative diseases with mortality, cardio- and cerebrovascular events in persons with chronic coronary syndrome |
| title_full_unstemmed | Associations of blood-based biomarkers of neurodegenerative diseases with mortality, cardio- and cerebrovascular events in persons with chronic coronary syndrome |
| title_short | Associations of blood-based biomarkers of neurodegenerative diseases with mortality, cardio- and cerebrovascular events in persons with chronic coronary syndrome |
| title_sort | associations of blood based biomarkers of neurodegenerative diseases with mortality cardio and cerebrovascular events in persons with chronic coronary syndrome |
| topic | Blood-based biomarkers of neurodegenerative diseases Mortality Coronary heart disease Chronic coronary syndrome Major cardiovascular events Cerebrovascular events |
| url | http://www.sciencedirect.com/science/article/pii/S0531556525000129 |
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