Natural Killer Cell-Secreted IFN-γ and TNF-α Mediated Differentiation in Lung Stem-like Tumors, Leading to the Susceptibility of the Tumors to Chemotherapeutic Drugs

Natural Killer Cell-Secreted IFN-γ and TNF-α Mediated Differentiation in Lung Stem-like Tumors, Leading to the Susceptibility of the Tumors to Chemotherapeutic Drugs

We demonstrate that natural killer (NK) cells induce a higher cytotoxicity against lung cancer stem-like cells (hA549) compared to differentiated lung cancer cell lines (H292). The supernatants from split-anergized NK cells (IL-2 and anti-CD16 mAb-treated NK cells) induced differentiation in hA549....

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Bibliographic Details
Main Authors: Kawaljit Kaur, Angie Perez Celis, Anahid Jewett
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Cells
Subjects:
NK cells
lung cancer
cancer stem cells (CSCs)
cytotoxicity
chemo-drugs
IFN-γ
Online Access:https://www.mdpi.com/2073-4409/14/2/90
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