Seroprevalence of Anti- N-methyl-D-aspartate receptor antibodies in children with seizures of unknown cause
Background. Anti- N-methyl-D-aspartate receptor (NMDAR) antibodies were found most probably to be accompanied by seizures, particularly in children and sometimes it may be the sole presenting feature. Therefore, testing these antibodies in children with seizure of unexplained cause might be h...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Hacettepe University Institute of Child Health
2021-06-01
|
| Series: | The Turkish Journal of Pediatrics |
| Subjects: | |
| Online Access: | https://turkjpediatr.org/article/view/312 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849705866810359808 |
|---|---|
| author | Mohammed Abdulrasol Abdulamer Nebal Waill Saadi Batool Ali Ghalib-Yassin Imad Al-Jumaili |
| author_facet | Mohammed Abdulrasol Abdulamer Nebal Waill Saadi Batool Ali Ghalib-Yassin Imad Al-Jumaili |
| author_sort | Mohammed Abdulrasol Abdulamer |
| collection | DOAJ |
| description |
Background. Anti- N-methyl-D-aspartate receptor (NMDAR) antibodies were found most probably to be accompanied by seizures, particularly in children and sometimes it may be the sole presenting feature. Therefore, testing these antibodies in children with seizure of unexplained cause might be helpful to identify the spectrum of these antibody-mediated disorders. The objective of this study was to determine the frequency of anti-NMDAR antibodies in patients who presented with seizures of unknown cause.
Methods. A case-control study was conducted in two hospitals in Medical City Complex-Baghdad in 2019. Children aged 2-18 years who manifested seizures solely without identified causes were recruited over a period of ten months, with an additional sex- and age-matched control group (forty children in each group). Serum was tested in both groups for anti-NMDAR antibodies.
Results. In the study group, males predominated in ages younger than 5 years. The mean age was 6.6 years and the mean duration since their seizures` onset was 2 months. In contrast to male patients, female patients manifested more focal seizures. Only 5 patients (12.5%) were positive for Anti- NMDAR antibodies, in contrast to no one in the control group. Significantly, most of the seropositive patients were females (4, 80%) and showed focal types of seizures (4, 80%).
Conclusions. This is a preliminary epidemiological study about the prevalence of anti-NMDAR antibodies in a sample of pediatric patients with isolated seizures of unknown cause. Anti-NMDAR antibodies were found to be prevalent in a relatively small proportion of children who presented with seizures of unknown causes. Demographic characteristics of the patients with variable testing status were found to be nearly comparable to the results from other related studies.
|
| format | Article |
| id | doaj-art-a290e15a964040718d4d7d90809a18ff |
| institution | DOAJ |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2021-06-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-a290e15a964040718d4d7d90809a18ff2025-08-20T03:16:22ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212021-06-0163310.24953/turkjped.2021.03.005Seroprevalence of Anti- N-methyl-D-aspartate receptor antibodies in children with seizures of unknown causeMohammed Abdulrasol Abdulamer0Nebal Waill SaadiBatool Ali Ghalib-Yassin1Imad Al-Jumaili2Unit of Pediatric Neurology, Children Welfare Teaching Hospital, Medical City Complex, Baghdad , Iraq.Departments of Community, College of Medicine, University of Baghdad, Baghdad , Iraq.Clinical Chemistry, MSc. Al-Nadaer Clinical Lab. Lab Director, Baghdad, Iraq. Background. Anti- N-methyl-D-aspartate receptor (NMDAR) antibodies were found most probably to be accompanied by seizures, particularly in children and sometimes it may be the sole presenting feature. Therefore, testing these antibodies in children with seizure of unexplained cause might be helpful to identify the spectrum of these antibody-mediated disorders. The objective of this study was to determine the frequency of anti-NMDAR antibodies in patients who presented with seizures of unknown cause. Methods. A case-control study was conducted in two hospitals in Medical City Complex-Baghdad in 2019. Children aged 2-18 years who manifested seizures solely without identified causes were recruited over a period of ten months, with an additional sex- and age-matched control group (forty children in each group). Serum was tested in both groups for anti-NMDAR antibodies. Results. In the study group, males predominated in ages younger than 5 years. The mean age was 6.6 years and the mean duration since their seizures` onset was 2 months. In contrast to male patients, female patients manifested more focal seizures. Only 5 patients (12.5%) were positive for Anti- NMDAR antibodies, in contrast to no one in the control group. Significantly, most of the seropositive patients were females (4, 80%) and showed focal types of seizures (4, 80%). Conclusions. This is a preliminary epidemiological study about the prevalence of anti-NMDAR antibodies in a sample of pediatric patients with isolated seizures of unknown cause. Anti-NMDAR antibodies were found to be prevalent in a relatively small proportion of children who presented with seizures of unknown causes. Demographic characteristics of the patients with variable testing status were found to be nearly comparable to the results from other related studies. https://turkjpediatr.org/article/view/312anti-NMDARautoimmunechildrenseizures |
| spellingShingle | Mohammed Abdulrasol Abdulamer Nebal Waill Saadi Batool Ali Ghalib-Yassin Imad Al-Jumaili Seroprevalence of Anti- N-methyl-D-aspartate receptor antibodies in children with seizures of unknown cause The Turkish Journal of Pediatrics anti-NMDAR autoimmune children seizures |
| title | Seroprevalence of Anti- N-methyl-D-aspartate receptor antibodies in children with seizures of unknown cause |
| title_full | Seroprevalence of Anti- N-methyl-D-aspartate receptor antibodies in children with seizures of unknown cause |
| title_fullStr | Seroprevalence of Anti- N-methyl-D-aspartate receptor antibodies in children with seizures of unknown cause |
| title_full_unstemmed | Seroprevalence of Anti- N-methyl-D-aspartate receptor antibodies in children with seizures of unknown cause |
| title_short | Seroprevalence of Anti- N-methyl-D-aspartate receptor antibodies in children with seizures of unknown cause |
| title_sort | seroprevalence of anti n methyl d aspartate receptor antibodies in children with seizures of unknown cause |
| topic | anti-NMDAR autoimmune children seizures |
| url | https://turkjpediatr.org/article/view/312 |
| work_keys_str_mv | AT mohammedabdulrasolabdulamer seroprevalenceofantinmethyldaspartatereceptorantibodiesinchildrenwithseizuresofunknowncause AT nebalwaillsaadi seroprevalenceofantinmethyldaspartatereceptorantibodiesinchildrenwithseizuresofunknowncause AT batoolalighalibyassin seroprevalenceofantinmethyldaspartatereceptorantibodiesinchildrenwithseizuresofunknowncause AT imadaljumaili seroprevalenceofantinmethyldaspartatereceptorantibodiesinchildrenwithseizuresofunknowncause |