Cerebral Epiphyseal Proteins and Melatonin Modulate the Hepatic and Renal Antioxidant Defense of Rats
The cerebral epiphysis (pineal gland) secrets melatonin and number of other proteins and peptides. It was thus hypothesized that antioxidant properties of epiphyseal proteins and melatonin could potentially benefit from exogenous therapies. In view of the therapeutic potential of these proteins, the...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Nephrology |
| Online Access: | http://dx.doi.org/10.4061/2011/142896 |
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| author | Vijay K. Bharti R. S. Srivastava P. Subramaian D. Warren Spence S. R. Pandi-Perumal Gregory M. Brown |
| author_facet | Vijay K. Bharti R. S. Srivastava P. Subramaian D. Warren Spence S. R. Pandi-Perumal Gregory M. Brown |
| author_sort | Vijay K. Bharti |
| collection | DOAJ |
| description | The cerebral epiphysis (pineal gland) secrets melatonin and number of other proteins and peptides. It was thus hypothesized that antioxidant properties of epiphyseal proteins and melatonin could potentially benefit from exogenous therapies. In view of the therapeutic potential of these proteins, the present experiment was conducted to investigate the effect of buffalo epiphyseal proteins (BEP, at 100 μg/kg BW, i.p.) and melatonin (MEL, at 10 mg/kg BW, i.p) on changes in hepatic and renal antioxidant enzymes of adult female Wistar rats. Buffalo epiphyseal proteins significantly (P<.05) increased hepatic lipid peroxidation (LPO), superoxide dismutase (SOD), glutathione reductase (GR), glutathione peroxidase (GPx), reduced glutathione (GSH), and renal LPO, catalase (CAT), GR, GSH, GPx levels as compared to control animals. Similarly, MEL treatment significantly (P<.05) up-regulated hepatic SOD and GPx activity, whereas CAT, GR, GPx, and GSH levels in renal tissues were increased while SOD and LPO remained unaffected. Buffalo epiphyseal protein treatment produced greater effects on hepatic GPx and renal CAT and GSH levels than did MEL. These findings support the conclusion that buffalo epiphyseal proteins and melatonin activate a number of antioxidant mechanisms in hepatic and renal tissues. |
| format | Article |
| id | doaj-art-a28625cf3edd40eb965ae4ebc9a7a940 |
| institution | Kabale University |
| issn | 2090-214X 2090-2158 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Nephrology |
| spelling | doaj-art-a28625cf3edd40eb965ae4ebc9a7a9402025-02-03T05:44:43ZengWileyInternational Journal of Nephrology2090-214X2090-21582011-01-01201110.4061/2011/142896142896Cerebral Epiphyseal Proteins and Melatonin Modulate the Hepatic and Renal Antioxidant Defense of RatsVijay K. Bharti0R. S. Srivastava1P. Subramaian2D. Warren Spence3S. R. Pandi-Perumal4Gregory M. Brown5Neurophysiology Laboratory, Division of Physiology and Climatology, Indian Veterinary Research Institute (IVRI), Izatnagar 243122, IndiaNeurophysiology Laboratory, Division of Physiology and Climatology, Indian Veterinary Research Institute (IVRI), Izatnagar 243122, IndiaDepartment of Biochemistry and Biotechnology, Faculty of Sciences, Annamalai University, Annamalainagar 608 002, India323 Brock Ave, Toronto, ON, M6K 2M6, CanadaSomnogen Inc., College Street, Toronto, ON, M6H 1C5, CanadaDepartment of Psychiatry, University of Toronto, 100 Bronte Road, Unit 422, Oakville, ON, L6L 6L5, CanadaThe cerebral epiphysis (pineal gland) secrets melatonin and number of other proteins and peptides. It was thus hypothesized that antioxidant properties of epiphyseal proteins and melatonin could potentially benefit from exogenous therapies. In view of the therapeutic potential of these proteins, the present experiment was conducted to investigate the effect of buffalo epiphyseal proteins (BEP, at 100 μg/kg BW, i.p.) and melatonin (MEL, at 10 mg/kg BW, i.p) on changes in hepatic and renal antioxidant enzymes of adult female Wistar rats. Buffalo epiphyseal proteins significantly (P<.05) increased hepatic lipid peroxidation (LPO), superoxide dismutase (SOD), glutathione reductase (GR), glutathione peroxidase (GPx), reduced glutathione (GSH), and renal LPO, catalase (CAT), GR, GSH, GPx levels as compared to control animals. Similarly, MEL treatment significantly (P<.05) up-regulated hepatic SOD and GPx activity, whereas CAT, GR, GPx, and GSH levels in renal tissues were increased while SOD and LPO remained unaffected. Buffalo epiphyseal protein treatment produced greater effects on hepatic GPx and renal CAT and GSH levels than did MEL. These findings support the conclusion that buffalo epiphyseal proteins and melatonin activate a number of antioxidant mechanisms in hepatic and renal tissues.http://dx.doi.org/10.4061/2011/142896 |
| spellingShingle | Vijay K. Bharti R. S. Srivastava P. Subramaian D. Warren Spence S. R. Pandi-Perumal Gregory M. Brown Cerebral Epiphyseal Proteins and Melatonin Modulate the Hepatic and Renal Antioxidant Defense of Rats International Journal of Nephrology |
| title | Cerebral Epiphyseal Proteins and Melatonin Modulate the Hepatic and Renal Antioxidant Defense of Rats |
| title_full | Cerebral Epiphyseal Proteins and Melatonin Modulate the Hepatic and Renal Antioxidant Defense of Rats |
| title_fullStr | Cerebral Epiphyseal Proteins and Melatonin Modulate the Hepatic and Renal Antioxidant Defense of Rats |
| title_full_unstemmed | Cerebral Epiphyseal Proteins and Melatonin Modulate the Hepatic and Renal Antioxidant Defense of Rats |
| title_short | Cerebral Epiphyseal Proteins and Melatonin Modulate the Hepatic and Renal Antioxidant Defense of Rats |
| title_sort | cerebral epiphyseal proteins and melatonin modulate the hepatic and renal antioxidant defense of rats |
| url | http://dx.doi.org/10.4061/2011/142896 |
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