Release Behavior and Toxicity Profiles towards Leukemia (WEHI-3B) Cell Lines of 6-Mercaptopurine-PEG-Coated Magnetite Nanoparticles Delivery System
The coating of an active drug, 6-mercaptopurine, into the iron oxide nanoparticles-polyethylene glycol (FNPs-PEG) in order to form a new nanocomposite, FPEGMP-2, was accomplished using coprecipitation technique. The resulting nanosized with a narrow size distribution magnetic polymeric particles sho...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/972501 |
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| author | Dena Dorniani Aminu Umar Kura Samer Hasan Hussein-Al-Ali Mohd Zobir bin Hussein Sharida Fakurazi Abdul Halim Shaari Zalinah Ahmad |
| author_facet | Dena Dorniani Aminu Umar Kura Samer Hasan Hussein-Al-Ali Mohd Zobir bin Hussein Sharida Fakurazi Abdul Halim Shaari Zalinah Ahmad |
| author_sort | Dena Dorniani |
| collection | DOAJ |
| description | The coating of an active drug, 6-mercaptopurine, into the iron oxide nanoparticles-polyethylene glycol (FNPs-PEG) in order to form a new nanocomposite, FPEGMP-2, was accomplished using coprecipitation technique. The resulting nanosized with a narrow size distribution magnetic polymeric particles show the superparamagnetic properties with 38.6 emu/g saturation magnetization at room temperature. Fourier transform infrared spectroscopy and the thermal analysis study supported the formation of the nanocomposite and the enhancement of thermal stability in the resulting nanocomposite comparing with its counterpart in free state. The loading of 6-mercaptopurine (MP) in the FPEGMP-2 nanocomposite was estimated to be about 5.6% and the kinetic experimental data properly correlated with the pseudo-second order model. Also, the release of MP from the FPEGMP-2 nanocomposite shows the sustained release manner which is remarkably lower in phosphate buffered solution at pH 7.4 than pH 4.8, due to different release mechanism. The maximum percentage release of MP from the nanocomposite reached about 60% and 97% within about 92 and 74 hours when exposed to pH 7.4 and 4.8, respectively. |
| format | Article |
| id | doaj-art-a27e61d1ebba41d6a1b98ef92258f7d8 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-a27e61d1ebba41d6a1b98ef92258f7d82025-08-20T03:38:44ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/972501972501Release Behavior and Toxicity Profiles towards Leukemia (WEHI-3B) Cell Lines of 6-Mercaptopurine-PEG-Coated Magnetite Nanoparticles Delivery SystemDena Dorniani0Aminu Umar Kura1Samer Hasan Hussein-Al-Ali2Mohd Zobir bin Hussein3Sharida Fakurazi4Abdul Halim Shaari5Zalinah Ahmad6Materials Synthesis and Characterization Laboratory (MSCL), Institute of Advanced Technology (ITMA), Universiti Putra Malaysia, 43400 Serdang, Selangor, MalaysiaVaccines and Immunotherapeutics Laboratory (IBS), Universiti Putra Malaysia, 43400 Serdang, Selangor, MalaysiaLaboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, 43400 Serdang, Selangor, MalaysiaMaterials Synthesis and Characterization Laboratory (MSCL), Institute of Advanced Technology (ITMA), Universiti Putra Malaysia, 43400 Serdang, Selangor, MalaysiaVaccines and Immunotherapeutics Laboratory (IBS), Universiti Putra Malaysia, 43400 Serdang, Selangor, MalaysiaPhysics Department, Faculty of Science, Universiti Putra Malaysia, 43400 Serdang, Selangor, MalaysiaVaccines and Immunotherapeutics Laboratory (IBS), Universiti Putra Malaysia, 43400 Serdang, Selangor, MalaysiaThe coating of an active drug, 6-mercaptopurine, into the iron oxide nanoparticles-polyethylene glycol (FNPs-PEG) in order to form a new nanocomposite, FPEGMP-2, was accomplished using coprecipitation technique. The resulting nanosized with a narrow size distribution magnetic polymeric particles show the superparamagnetic properties with 38.6 emu/g saturation magnetization at room temperature. Fourier transform infrared spectroscopy and the thermal analysis study supported the formation of the nanocomposite and the enhancement of thermal stability in the resulting nanocomposite comparing with its counterpart in free state. The loading of 6-mercaptopurine (MP) in the FPEGMP-2 nanocomposite was estimated to be about 5.6% and the kinetic experimental data properly correlated with the pseudo-second order model. Also, the release of MP from the FPEGMP-2 nanocomposite shows the sustained release manner which is remarkably lower in phosphate buffered solution at pH 7.4 than pH 4.8, due to different release mechanism. The maximum percentage release of MP from the nanocomposite reached about 60% and 97% within about 92 and 74 hours when exposed to pH 7.4 and 4.8, respectively.http://dx.doi.org/10.1155/2014/972501 |
| spellingShingle | Dena Dorniani Aminu Umar Kura Samer Hasan Hussein-Al-Ali Mohd Zobir bin Hussein Sharida Fakurazi Abdul Halim Shaari Zalinah Ahmad Release Behavior and Toxicity Profiles towards Leukemia (WEHI-3B) Cell Lines of 6-Mercaptopurine-PEG-Coated Magnetite Nanoparticles Delivery System The Scientific World Journal |
| title | Release Behavior and Toxicity Profiles towards Leukemia (WEHI-3B) Cell Lines of 6-Mercaptopurine-PEG-Coated Magnetite Nanoparticles Delivery System |
| title_full | Release Behavior and Toxicity Profiles towards Leukemia (WEHI-3B) Cell Lines of 6-Mercaptopurine-PEG-Coated Magnetite Nanoparticles Delivery System |
| title_fullStr | Release Behavior and Toxicity Profiles towards Leukemia (WEHI-3B) Cell Lines of 6-Mercaptopurine-PEG-Coated Magnetite Nanoparticles Delivery System |
| title_full_unstemmed | Release Behavior and Toxicity Profiles towards Leukemia (WEHI-3B) Cell Lines of 6-Mercaptopurine-PEG-Coated Magnetite Nanoparticles Delivery System |
| title_short | Release Behavior and Toxicity Profiles towards Leukemia (WEHI-3B) Cell Lines of 6-Mercaptopurine-PEG-Coated Magnetite Nanoparticles Delivery System |
| title_sort | release behavior and toxicity profiles towards leukemia wehi 3b cell lines of 6 mercaptopurine peg coated magnetite nanoparticles delivery system |
| url | http://dx.doi.org/10.1155/2014/972501 |
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