Correlation of Fibroblast Growth Factor-23 Levels with Hand Grip Strength in Twice Weekly Hemodialysis Patients
Introduction. One of the main factors involved in bone mineral and musculoskeletal disorders in patients with chronic kidney disease (CKD) is fibroblast growth factor-23 (FGF-23). Fibroblast growth factor 23 (FGF-23) levels are elevated in hemodialysis patients. Despite FGF-23 associated left ventri...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | Indonesian |
| Published: |
Department of Internal Medicine, Faculty of Medicine Universitas Indonesia
2020-03-01
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| Series: | Jurnal Penyakit Dalam Indonesia |
| Subjects: | |
| Online Access: | http://jurnalpenyakitdalam.ui.ac.id/index.php/jpdi/article/view/325/221 |
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| Summary: | Introduction. One of the main factors involved in bone mineral and musculoskeletal disorders in patients with chronic kidney disease (CKD) is fibroblast growth factor-23 (FGF-23). Fibroblast growth factor 23 (FGF-23) levels are elevated in hemodialysis patients. Despite FGF-23 associated left ventricular hypertrophy, there are no prior studies assessing whether FGF-23 level is associated with skeletal muscle strength in hemodialysis patient. This study aimed to determine the correlation between hand-grip strength (HGS) and FGF-23 levels in patients undergoing twice weekly hemodialysis patients.
Methods. A cross-sectional study was conducted on patients with twice weekly hemodialysis at the Hemodialysis Unit at Dr Cipto Mangunkusumo Hospital, Jakarta. We measured intact fibroblast growth factor-23 and hand grip strength that measured by Jamar hydraulic hand dynamometer. Subject selection was done by consecutive sampling until the required number of subjects was fulfilled.
Results. A total of 74 subjects were included in this study which serum FGF23 levels were significantly higher in males (median 3,276 pg/ml [range 41-6,613 pg/ml]) than in females (median 1,585 pg/ml [range 21-4,820 pg/ml]). The HGS value of male patients was 25 kg (range 11-48 kg), while in female patients was 20 kg (range 8-26 kg). After adjusting for modified charlson comorbidity index (mCCI) and body mass index, there was no correlation between FGF-23 and HGS in male subject (r = -0.053, p = 0.7), but the correlation FGF-23 and HGS in the female subject was significant (r = -0.4, p = 0.02).
Conclusion. In twice weekly hemodialysis patients, FGF-23 has a significant correlation with HGS in women with body mass index >18,5 kg/m2 and this correlation was not found in the male subjects. |
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| ISSN: | 2406-8969 2549-0621 |