Repertoire-based mapping and time-tracking of T helper cell subsets in scRNA-Seq

Repertoire-based mapping and time-tracking of T helper cell subsets in scRNA-Seq

IntroductionThe functional programs of CD4+ T helper (Th) cell clones play a central role in shaping immune responses to different challenges. While advances in single-cell RNA sequencing (scRNA-Seq) have significantly improved our understanding of the diversity of Th cells, the relationship between...

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Main Authors: Daniil K. Lukyanov, Valeriia V. Kriukova, Kristin Ladell, Irina A. Shagina, Dmitry B. Staroverov, Bella E. Minasian, Anna S. Fedosova, Pavel Shelyakin, Oleg N. Suchalko, Alexander Y. Komkov, Konstantin A. Blagodatskikh, Kelly L. Miners, Olga V. Britanova, Andre Franke, David A. Price, Dmitry M. Chudakov
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Immunology
Subjects:
helper T cell subsets
scRNA-Seq
scTCR-seq
immune repertoires
T cell memory
Th22
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1536302/full
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