Carboxyhemoglobin Does Not Predict the Need of Mechanical Ventilation and Prognosis during COPD Exacerbation
Background. Carboxyhemoglobin (COHb) is a complex formed by the binding of carbon monoxide to hemoglobin in blood. Higher COHb levels have been associated with poor prognosis in a variety of pulmonary disorders. However, little is known regarding the prognostic significance of COHb among individuals...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Canadian Respiratory Journal |
| Online Access: | http://dx.doi.org/10.1155/2022/6689805 |
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| author | Shimon Izhakian Eitan Harper Oleg Gorelik Assaf Frajman Ori Mekiten Adina Bar-Chaim Mordechai Reuven Kramer |
| author_facet | Shimon Izhakian Eitan Harper Oleg Gorelik Assaf Frajman Ori Mekiten Adina Bar-Chaim Mordechai Reuven Kramer |
| author_sort | Shimon Izhakian |
| collection | DOAJ |
| description | Background. Carboxyhemoglobin (COHb) is a complex formed by the binding of carbon monoxide to hemoglobin in blood. Higher COHb levels have been associated with poor prognosis in a variety of pulmonary disorders. However, little is known regarding the prognostic significance of COHb among individuals with chronic obstructive pulmonary disease (COPD) exacerbation. Methods. In a retrospective study, we evaluated associations of venous COHb levels on hospital admission with the need for invasive mechanical ventilation, in-hospital mortality, and rehospitalization, among 300 patients hospitalized for COPD exacerbation in internal medical wards. Results. Rates of in-hospital death and 1-year recurrent hospitalizations were 11.0% and 59.6%, respectively. COHb levels were not significantly associated with in-hospital mortality (OR = 0.82, P=0.25, 95% CI 0.59–1.15) or with 1-year rehospitalizations (OR = 0.91, P=0.18, 95% CI 0.79–1.04). The mean COHb level did not differ significantly between patients who needed invasive mechanical ventilation and those who were not invasively mechanically ventilated during the current hospitalization (2.01 ± 1.42% vs. 2.19 ± 1.68%, P=0.49). Conclusions. Among patients hospitalized with COPD exacerbation in internal medicine wards, COHb levels on admission were not associated with invasive mechanical ventilation treatment, rehospitalizations, or mortality. |
| format | Article |
| id | doaj-art-a24c0e2ad269448dbc0a9eccce29eebe |
| institution | Kabale University |
| issn | 1916-7245 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Respiratory Journal |
| spelling | doaj-art-a24c0e2ad269448dbc0a9eccce29eebe2025-02-03T01:20:34ZengWileyCanadian Respiratory Journal1916-72452022-01-01202210.1155/2022/6689805Carboxyhemoglobin Does Not Predict the Need of Mechanical Ventilation and Prognosis during COPD ExacerbationShimon Izhakian0Eitan Harper1Oleg Gorelik2Assaf Frajman3Ori Mekiten4Adina Bar-Chaim5Mordechai Reuven Kramer6Department of Internal Medicine FDepartment of Internal Medicine FDepartment of Internal Medicine FDepartment of Internal Medicine FDepartment of Internal Medicine FAffiliated to Sackler Faculty of MedicineAffiliated to Sackler Faculty of MedicineBackground. Carboxyhemoglobin (COHb) is a complex formed by the binding of carbon monoxide to hemoglobin in blood. Higher COHb levels have been associated with poor prognosis in a variety of pulmonary disorders. However, little is known regarding the prognostic significance of COHb among individuals with chronic obstructive pulmonary disease (COPD) exacerbation. Methods. In a retrospective study, we evaluated associations of venous COHb levels on hospital admission with the need for invasive mechanical ventilation, in-hospital mortality, and rehospitalization, among 300 patients hospitalized for COPD exacerbation in internal medical wards. Results. Rates of in-hospital death and 1-year recurrent hospitalizations were 11.0% and 59.6%, respectively. COHb levels were not significantly associated with in-hospital mortality (OR = 0.82, P=0.25, 95% CI 0.59–1.15) or with 1-year rehospitalizations (OR = 0.91, P=0.18, 95% CI 0.79–1.04). The mean COHb level did not differ significantly between patients who needed invasive mechanical ventilation and those who were not invasively mechanically ventilated during the current hospitalization (2.01 ± 1.42% vs. 2.19 ± 1.68%, P=0.49). Conclusions. Among patients hospitalized with COPD exacerbation in internal medicine wards, COHb levels on admission were not associated with invasive mechanical ventilation treatment, rehospitalizations, or mortality.http://dx.doi.org/10.1155/2022/6689805 |
| spellingShingle | Shimon Izhakian Eitan Harper Oleg Gorelik Assaf Frajman Ori Mekiten Adina Bar-Chaim Mordechai Reuven Kramer Carboxyhemoglobin Does Not Predict the Need of Mechanical Ventilation and Prognosis during COPD Exacerbation Canadian Respiratory Journal |
| title | Carboxyhemoglobin Does Not Predict the Need of Mechanical Ventilation and Prognosis during COPD Exacerbation |
| title_full | Carboxyhemoglobin Does Not Predict the Need of Mechanical Ventilation and Prognosis during COPD Exacerbation |
| title_fullStr | Carboxyhemoglobin Does Not Predict the Need of Mechanical Ventilation and Prognosis during COPD Exacerbation |
| title_full_unstemmed | Carboxyhemoglobin Does Not Predict the Need of Mechanical Ventilation and Prognosis during COPD Exacerbation |
| title_short | Carboxyhemoglobin Does Not Predict the Need of Mechanical Ventilation and Prognosis during COPD Exacerbation |
| title_sort | carboxyhemoglobin does not predict the need of mechanical ventilation and prognosis during copd exacerbation |
| url | http://dx.doi.org/10.1155/2022/6689805 |
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