Engineering the bone metastatic prostate cancer niche through a microphysiological system to report patient-specific treatment response

Engineering the bone metastatic prostate cancer niche through a microphysiological system to report patient-specific treatment response

Abstract Bone is the most common site of prostate cancer metastasis, leading to significant morbidity, treatment resistance, and mortality. A major challenge in understanding treatment response is the complex, bone metastatic niche. Here, we report the first patient-specific microphysiological syste...

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Main Authors: Cristina Sánchez-de-Diego, Ravi Chandra Yada, Nan Sethakorn, Peter G. Geiger, Adeline B. Ding, Erika Heninger, Fauzan Ahmed, María Virumbrales-Muñoz, Nikolett Lupsa, Emmett Bartels, Kacey Stewart, Suzanne M. Ponik, Marina N. Sharifi, Joshua M. Lang, David J. Beebe, Sheena C. Kerr
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08384-2
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