Tempol Attenuates Neuropathic Pain by Inhibiting Nitric Oxide Production
Background. Neuropathic pain not only affects individual life quality but also increases economic burden for the society. Treatment to alleviate neuropathic pain is required. Methodology. Fifty rats were randomly assigned into sham, spinal nerve ligation, and three treatment groups with different do...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Analytical Cellular Pathology |
| Online Access: | http://dx.doi.org/10.1155/2019/8253850 |
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| author | Donglin Jia Huan Wang Bin Han Liping Zhang Jianrong Guo |
| author_facet | Donglin Jia Huan Wang Bin Han Liping Zhang Jianrong Guo |
| author_sort | Donglin Jia |
| collection | DOAJ |
| description | Background. Neuropathic pain not only affects individual life quality but also increases economic burden for the society. Treatment to alleviate neuropathic pain is required. Methodology. Fifty rats were randomly assigned into sham, spinal nerve ligation, and three treatment groups with different doses of Tempol (100, 200, and 300 mg/kg, respectively), with 10 rats in each group. A neuropathic pain model was created with spinal nerve L5 and L6 ligation. Mechanical allodynia and thermal hyperalgesia were tested preoperatively (day 0) and postoperatively (days 1, 3, 5, and 7). Spinal cord levels of nitric oxide, as well as activities of nitric oxide synthase and acetylcholinesterase, were tested in postoperative day 7. Results. Compared with rats in the spinal nerve ligation group, rats in Tempol treatment groups had decreased responses to mechanical pain and cold plate stimulations. A high dose of Tempol produced more attenuating effects. The level of nitric oxide and activity of nitric oxide synthase were also decreased with Tempol treatments, whereas no significant changes were observed in the activity of acetylcholinesterase. Conclusions. Tempol attenuated an experimental rat model with neuropathic pain by inhibiting nitric oxide production. |
| format | Article |
| id | doaj-art-a234c546be7647329acbc5f3b6c169d3 |
| institution | Kabale University |
| issn | 2210-7177 2210-7185 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Analytical Cellular Pathology |
| spelling | doaj-art-a234c546be7647329acbc5f3b6c169d32025-02-03T00:59:39ZengWileyAnalytical Cellular Pathology2210-71772210-71852019-01-01201910.1155/2019/82538508253850Tempol Attenuates Neuropathic Pain by Inhibiting Nitric Oxide ProductionDonglin Jia0Huan Wang1Bin Han2Liping Zhang3Jianrong Guo4Department of Pain Medicine, Peking University Third Hospital, Beijing 100191, ChinaDepartment of Anesthesiology, Gongli Hospital, The Second Military Medical University, Pudong New District, Shanghai 200135, ChinaDepartment of Anesthesiology, Peking University Third Hospital, Beijing 100191, ChinaDepartment of Anesthesiology, Peking University Third Hospital, Beijing 100191, ChinaDepartment of Anesthesiology, Gongli Hospital, The Second Military Medical University, Pudong New District, Shanghai 200135, ChinaBackground. Neuropathic pain not only affects individual life quality but also increases economic burden for the society. Treatment to alleviate neuropathic pain is required. Methodology. Fifty rats were randomly assigned into sham, spinal nerve ligation, and three treatment groups with different doses of Tempol (100, 200, and 300 mg/kg, respectively), with 10 rats in each group. A neuropathic pain model was created with spinal nerve L5 and L6 ligation. Mechanical allodynia and thermal hyperalgesia were tested preoperatively (day 0) and postoperatively (days 1, 3, 5, and 7). Spinal cord levels of nitric oxide, as well as activities of nitric oxide synthase and acetylcholinesterase, were tested in postoperative day 7. Results. Compared with rats in the spinal nerve ligation group, rats in Tempol treatment groups had decreased responses to mechanical pain and cold plate stimulations. A high dose of Tempol produced more attenuating effects. The level of nitric oxide and activity of nitric oxide synthase were also decreased with Tempol treatments, whereas no significant changes were observed in the activity of acetylcholinesterase. Conclusions. Tempol attenuated an experimental rat model with neuropathic pain by inhibiting nitric oxide production.http://dx.doi.org/10.1155/2019/8253850 |
| spellingShingle | Donglin Jia Huan Wang Bin Han Liping Zhang Jianrong Guo Tempol Attenuates Neuropathic Pain by Inhibiting Nitric Oxide Production Analytical Cellular Pathology |
| title | Tempol Attenuates Neuropathic Pain by Inhibiting Nitric Oxide Production |
| title_full | Tempol Attenuates Neuropathic Pain by Inhibiting Nitric Oxide Production |
| title_fullStr | Tempol Attenuates Neuropathic Pain by Inhibiting Nitric Oxide Production |
| title_full_unstemmed | Tempol Attenuates Neuropathic Pain by Inhibiting Nitric Oxide Production |
| title_short | Tempol Attenuates Neuropathic Pain by Inhibiting Nitric Oxide Production |
| title_sort | tempol attenuates neuropathic pain by inhibiting nitric oxide production |
| url | http://dx.doi.org/10.1155/2019/8253850 |
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