Germinal center dynamics during acute and chronic infection

The ability of the immune system to clear pathogens is limited during chronic virus infections where potent long-lived plasma and memory B-cells are produced only after germinal center B-cells undergo many rounds of somatic hypermutations. In this paper, we investigate the mechanisms of germinal cen...

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Bibliographic Details
Main Authors: Samantha Erwin, Stanca M. Ciupe
Format: Article
Language:English
Published: AIMS Press 2017-05-01
Series:Mathematical Biosciences and Engineering
Subjects:
Online Access:https://www.aimspress.com/article/doi/10.3934/mbe.2017037
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