Germinal center dynamics during acute and chronic infection
The ability of the immune system to clear pathogens is limited during chronic virus infections where potent long-lived plasma and memory B-cells are produced only after germinal center B-cells undergo many rounds of somatic hypermutations. In this paper, we investigate the mechanisms of germinal cen...
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| Format: | Article |
| Language: | English |
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AIMS Press
2017-05-01
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| Series: | Mathematical Biosciences and Engineering |
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| Online Access: | https://www.aimspress.com/article/doi/10.3934/mbe.2017037 |
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| _version_ | 1832590070329114624 |
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| author | Samantha Erwin Stanca M. Ciupe |
| author_facet | Samantha Erwin Stanca M. Ciupe |
| author_sort | Samantha Erwin |
| collection | DOAJ |
| description | The ability of the immune system to clear pathogens is limited during chronic virus infections where potent long-lived plasma and memory B-cells are produced only after germinal center B-cells undergo many rounds of somatic hypermutations. In this paper, we investigate the mechanisms of germinal center B-cell formation by developing mathematical models for the dynamics of B-cell somatic hypermutations. We use the models to determine how B-cell selection and competition for T follicular helper cells and antigen influences the size and composition of germinal centers in acute and chronic infections. We predict that the T follicular helper cells are a limiting resource in driving large numbers of somatic hypermutations and present possible mechanisms that can revert this limitation in the presence of non-mutating and mutating antigen. |
| format | Article |
| id | doaj-art-a22e5a02c08e4dc6a884f3d739aa7189 |
| institution | Kabale University |
| issn | 1551-0018 |
| language | English |
| publishDate | 2017-05-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | Mathematical Biosciences and Engineering |
| spelling | doaj-art-a22e5a02c08e4dc6a884f3d739aa71892025-01-24T02:39:47ZengAIMS PressMathematical Biosciences and Engineering1551-00182017-05-0114365567110.3934/mbe.2017037Germinal center dynamics during acute and chronic infectionSamantha Erwin0Stanca M. Ciupe1460 McBryde Hall, Virginia Tech, Blacksburg, VA 24061, USA460 McBryde Hall, Virginia Tech, Blacksburg, VA 24061, USAThe ability of the immune system to clear pathogens is limited during chronic virus infections where potent long-lived plasma and memory B-cells are produced only after germinal center B-cells undergo many rounds of somatic hypermutations. In this paper, we investigate the mechanisms of germinal center B-cell formation by developing mathematical models for the dynamics of B-cell somatic hypermutations. We use the models to determine how B-cell selection and competition for T follicular helper cells and antigen influences the size and composition of germinal centers in acute and chronic infections. We predict that the T follicular helper cells are a limiting resource in driving large numbers of somatic hypermutations and present possible mechanisms that can revert this limitation in the presence of non-mutating and mutating antigen.https://www.aimspress.com/article/doi/10.3934/mbe.2017037b cellstfh cellsgerminal centerssomatic hypermutationsmathematical models |
| spellingShingle | Samantha Erwin Stanca M. Ciupe Germinal center dynamics during acute and chronic infection Mathematical Biosciences and Engineering b cells tfh cells germinal centers somatic hypermutations mathematical models |
| title | Germinal center dynamics during acute and chronic infection |
| title_full | Germinal center dynamics during acute and chronic infection |
| title_fullStr | Germinal center dynamics during acute and chronic infection |
| title_full_unstemmed | Germinal center dynamics during acute and chronic infection |
| title_short | Germinal center dynamics during acute and chronic infection |
| title_sort | germinal center dynamics during acute and chronic infection |
| topic | b cells tfh cells germinal centers somatic hypermutations mathematical models |
| url | https://www.aimspress.com/article/doi/10.3934/mbe.2017037 |
| work_keys_str_mv | AT samanthaerwin germinalcenterdynamicsduringacuteandchronicinfection AT stancamciupe germinalcenterdynamicsduringacuteandchronicinfection |