Adult Height after Growth Hormone Treatment at Pubertal Onset in Short Adolescents Born Small for Gestational Age: Results from a Belgian Registry-Based Study
Objectives. Information on the efficacy of GH treatment in short SGA children starting their treatment in adolescence is limited. Therefore, adult height (AH), total height gain, and pubertal height gain were evaluated in short SGA children who started GH treatment at pubertal onset. Patient and Met...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2018/6421243 |
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| author | M. Thomas D. Beckers C. Brachet H. Dotremont M.-C. Lebrethon P. Lysy G. Massa N. Reynaert R. Rooman S. van der Straaten M. Roelants J. De Schepper |
| author_facet | M. Thomas D. Beckers C. Brachet H. Dotremont M.-C. Lebrethon P. Lysy G. Massa N. Reynaert R. Rooman S. van der Straaten M. Roelants J. De Schepper |
| author_sort | M. Thomas |
| collection | DOAJ |
| description | Objectives. Information on the efficacy of GH treatment in short SGA children starting their treatment in adolescence is limited. Therefore, adult height (AH), total height gain, and pubertal height gain were evaluated in short SGA children who started GH treatment at pubertal onset. Patient and Methods. Growth data of 47 short SGA adolescents (22 boys) who started GH treatment at pubertal onset (PUB group) were compared with results from 27 short SGA patients (11 boys) who started GH therapy at least 1 year before pubertal onset (PrePUB group). Results. The PUB group achieved a mean (±SD) total height gain of 0.8 ± 0.7 SDS and an AH of −2.5 ± 0.7 SDS after 4.1 ± 1.1 years of GH treatment with a dosage of 41.8 ± 8.4 μg/kg/day. These results were comparable with those in the PrePUB group, which was treated for a longer duration (5.8 ± 2.1 years), resulting in a total height gain of 1.1 ± 0.7 SDS and an AH of −2.1 ± 1.0 SDS. Multiple regression analysis showed a significantly lower height gain in pubertal patients, females, and patients weighing less at start of GH treatment. An AH above −2 SDS and above the parent-specific lower limit of height was, respectively, reached in 28% and 70% of PUB and 44% and 67% of PrePUB patients (NS). AH SDS was positively correlated with the height SDS at start of GH. Conclusions. Short SGA adolescents starting GH therapy at an early pubertal stage have a modest and variable height gain. A normal AH can be expected in one third of the patients, especially in those with a smaller height deficit at onset of GH treatment. |
| format | Article |
| id | doaj-art-a22a6198c18743169b28d71373a6b4cf |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-a22a6198c18743169b28d71373a6b4cf2025-02-03T01:02:30ZengWileyInternational Journal of Endocrinology1687-83371687-83452018-01-01201810.1155/2018/64212436421243Adult Height after Growth Hormone Treatment at Pubertal Onset in Short Adolescents Born Small for Gestational Age: Results from a Belgian Registry-Based StudyM. Thomas0D. Beckers1C. Brachet2H. Dotremont3M.-C. Lebrethon4P. Lysy5G. Massa6N. Reynaert7R. Rooman8S. van der Straaten9M. Roelants10J. De Schepper11The Belgian Society for Pediatric Endocrinology and Diabetology (BESPEED), Bruxelles, BelgiumDivision of Pediatric Endocrinology, Université catholique de Louvain, CHU UCL Namur, Yvoir, BelgiumDivision of Pediatric Endocrinology, Hôpital Universitaire des Enfants Reine Fabiola (HUDERF), Bruxelles, BelgiumDivision of Pediatric Endocrinology, UZ Antwerpen, Antwerpen, BelgiumDivision of Pediatric Endocrinology, CHU-Notre-Dame des Bruyères, Chênée, BelgiumDivision of Pediatric Endocrinology, Cliniques Universitaires Saint-Luc, Bruxelles, BelgiumDivision of Pediatric Endocrinology, Jessa Ziekenhuis, Hasselt, BelgiumDivision of Pediatric Endocrinology, UZ Leuven, Leuven, BelgiumThe Belgian Society for Pediatric Endocrinology and Diabetology (BESPEED), Bruxelles, BelgiumDivision of Pediatric Endocrinology, UZ Gent, Gent, BelgiumDepartment of Public Health and Primary Care, KU Leuven, Leuven, BelgiumDivision of Pediatric Endocrinology, UZ Brussel, Brussel, BelgiumObjectives. Information on the efficacy of GH treatment in short SGA children starting their treatment in adolescence is limited. Therefore, adult height (AH), total height gain, and pubertal height gain were evaluated in short SGA children who started GH treatment at pubertal onset. Patient and Methods. Growth data of 47 short SGA adolescents (22 boys) who started GH treatment at pubertal onset (PUB group) were compared with results from 27 short SGA patients (11 boys) who started GH therapy at least 1 year before pubertal onset (PrePUB group). Results. The PUB group achieved a mean (±SD) total height gain of 0.8 ± 0.7 SDS and an AH of −2.5 ± 0.7 SDS after 4.1 ± 1.1 years of GH treatment with a dosage of 41.8 ± 8.4 μg/kg/day. These results were comparable with those in the PrePUB group, which was treated for a longer duration (5.8 ± 2.1 years), resulting in a total height gain of 1.1 ± 0.7 SDS and an AH of −2.1 ± 1.0 SDS. Multiple regression analysis showed a significantly lower height gain in pubertal patients, females, and patients weighing less at start of GH treatment. An AH above −2 SDS and above the parent-specific lower limit of height was, respectively, reached in 28% and 70% of PUB and 44% and 67% of PrePUB patients (NS). AH SDS was positively correlated with the height SDS at start of GH. Conclusions. Short SGA adolescents starting GH therapy at an early pubertal stage have a modest and variable height gain. A normal AH can be expected in one third of the patients, especially in those with a smaller height deficit at onset of GH treatment.http://dx.doi.org/10.1155/2018/6421243 |
| spellingShingle | M. Thomas D. Beckers C. Brachet H. Dotremont M.-C. Lebrethon P. Lysy G. Massa N. Reynaert R. Rooman S. van der Straaten M. Roelants J. De Schepper Adult Height after Growth Hormone Treatment at Pubertal Onset in Short Adolescents Born Small for Gestational Age: Results from a Belgian Registry-Based Study International Journal of Endocrinology |
| title | Adult Height after Growth Hormone Treatment at Pubertal Onset in Short Adolescents Born Small for Gestational Age: Results from a Belgian Registry-Based Study |
| title_full | Adult Height after Growth Hormone Treatment at Pubertal Onset in Short Adolescents Born Small for Gestational Age: Results from a Belgian Registry-Based Study |
| title_fullStr | Adult Height after Growth Hormone Treatment at Pubertal Onset in Short Adolescents Born Small for Gestational Age: Results from a Belgian Registry-Based Study |
| title_full_unstemmed | Adult Height after Growth Hormone Treatment at Pubertal Onset in Short Adolescents Born Small for Gestational Age: Results from a Belgian Registry-Based Study |
| title_short | Adult Height after Growth Hormone Treatment at Pubertal Onset in Short Adolescents Born Small for Gestational Age: Results from a Belgian Registry-Based Study |
| title_sort | adult height after growth hormone treatment at pubertal onset in short adolescents born small for gestational age results from a belgian registry based study |
| url | http://dx.doi.org/10.1155/2018/6421243 |
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