Molecular correlates of glycine receptor activity in human β cells

Molecular correlates of glycine receptor activity in human β cells

Objectives: Glycine acts in an autocrine positive feedback loop in human β cells through its ionotropic receptors (GlyRs). In type 2 diabetes (T2D), islet GlyR activity is impaired by unknown mechanisms. We sought to investigate if the GlyR dysfunction in T2D is replicated by hyperglycemia per se, a...

Full description

Saved in:
Bibliographic Details
Main Authors: Amanda Schukarucha Gomes, Cara E. Ellis, Aliya F. Spigelman, Theodore dos Santos, Jasmine Maghera, Kunimasa Suzuki, Patrick E. MacDonald
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Molecular Metabolism
Subjects:
β cells
Human islets
Glycine receptors
Hyperglycemia
Type 2 diabetes
EIF4EBP1
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877825000638
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items