One‐pot synthesis chlorin e6 nano‐precipitation for colorectal cancer treatment Ce6 NPs for colorectal cancer treatment
Abstract The drug nanoparticles free of additional carriers hold great promise in drug delivery and are suitable for the therapy of cancers. Herein, we developed a one‐pot method to prepare chlorin e6 (Ce6) nano‐precipitations (Ce6 NPs) for effective photodynamic therapy of colorectal cancer. The dr...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-10-01
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| Series: | IET Nanobiotechnology |
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| Online Access: | https://doi.org/10.1049/nbt2.12065 |
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| _version_ | 1832559641206194176 |
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| author | Zhongxing Miao Yujie Wang Shengjie Li Min Zhang Meng Xu |
| author_facet | Zhongxing Miao Yujie Wang Shengjie Li Min Zhang Meng Xu |
| author_sort | Zhongxing Miao |
| collection | DOAJ |
| description | Abstract The drug nanoparticles free of additional carriers hold great promise in drug delivery and are suitable for the therapy of cancers. Herein, we developed a one‐pot method to prepare chlorin e6 (Ce6) nano‐precipitations (Ce6 NPs) for effective photodynamic therapy of colorectal cancer. The drug loading of Ce6 NPs was around 81% and showed acceptable stability, high biocompatibility as well as effective reactive oxygen species (ROS) generation capability. As a result, the Ce6 NPs can produce significantly elevated ROS upon laser irradiations and achieved better anticancer benefits than free Ce6. |
| format | Article |
| id | doaj-art-a22816fc7f164881b10256f30f8638f7 |
| institution | Kabale University |
| issn | 1751-8741 1751-875X |
| language | English |
| publishDate | 2021-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | IET Nanobiotechnology |
| spelling | doaj-art-a22816fc7f164881b10256f30f8638f72025-02-03T01:29:38ZengWileyIET Nanobiotechnology1751-87411751-875X2021-10-0115868068510.1049/nbt2.12065One‐pot synthesis chlorin e6 nano‐precipitation for colorectal cancer treatment Ce6 NPs for colorectal cancer treatmentZhongxing Miao0Yujie Wang1Shengjie Li2Min Zhang3Meng Xu4Department of Gastroenterology Surgery Dalian Municipal Central Hospital Dalian Liaoning ChinaDepartment of Gastroenterology Surgery Dalian Municipal Central Hospital Dalian Liaoning ChinaDepartment of Gastroenterology Surgery Dalian Municipal Central Hospital Dalian Liaoning ChinaDepartment of Department of Anorectal Surgery Dalian Municipal Central Hospital Dalian Liaoning ChinaDepartment of Department of Anorectal Surgery Dalian Municipal Central Hospital Dalian Liaoning ChinaAbstract The drug nanoparticles free of additional carriers hold great promise in drug delivery and are suitable for the therapy of cancers. Herein, we developed a one‐pot method to prepare chlorin e6 (Ce6) nano‐precipitations (Ce6 NPs) for effective photodynamic therapy of colorectal cancer. The drug loading of Ce6 NPs was around 81% and showed acceptable stability, high biocompatibility as well as effective reactive oxygen species (ROS) generation capability. As a result, the Ce6 NPs can produce significantly elevated ROS upon laser irradiations and achieved better anticancer benefits than free Ce6.https://doi.org/10.1049/nbt2.12065biochemistrybiomedical materialscancercellular biophysicsdrug delivery systemsdrugs |
| spellingShingle | Zhongxing Miao Yujie Wang Shengjie Li Min Zhang Meng Xu One‐pot synthesis chlorin e6 nano‐precipitation for colorectal cancer treatment Ce6 NPs for colorectal cancer treatment IET Nanobiotechnology biochemistry biomedical materials cancer cellular biophysics drug delivery systems drugs |
| title | One‐pot synthesis chlorin e6 nano‐precipitation for colorectal cancer treatment Ce6 NPs for colorectal cancer treatment |
| title_full | One‐pot synthesis chlorin e6 nano‐precipitation for colorectal cancer treatment Ce6 NPs for colorectal cancer treatment |
| title_fullStr | One‐pot synthesis chlorin e6 nano‐precipitation for colorectal cancer treatment Ce6 NPs for colorectal cancer treatment |
| title_full_unstemmed | One‐pot synthesis chlorin e6 nano‐precipitation for colorectal cancer treatment Ce6 NPs for colorectal cancer treatment |
| title_short | One‐pot synthesis chlorin e6 nano‐precipitation for colorectal cancer treatment Ce6 NPs for colorectal cancer treatment |
| title_sort | one pot synthesis chlorin e6 nano precipitation for colorectal cancer treatment ce6 nps for colorectal cancer treatment |
| topic | biochemistry biomedical materials cancer cellular biophysics drug delivery systems drugs |
| url | https://doi.org/10.1049/nbt2.12065 |
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