Evaluation of urinary density as a biomarker for the diagnosis of acute heart failure
Background Heart failure (HF) has become a public healthcare concern with significant costs to countries because of the aging world population. Acute heart failure (AHF) is a common condition faced frequently in emergency departments, and patients often present to hospitals with complaints of breath...
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PeerJ Inc.
2025-01-01
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| author | Mustafa Ahmet Akçalı Semih Çınar Kemal Abid Tekin Recep Murat Mert Sena Erduhan Ertuğ Dinçer Yusuf Altunöz Arif Aksu Esra Akçalı |
| author_facet | Mustafa Ahmet Akçalı Semih Çınar Kemal Abid Tekin Recep Murat Mert Sena Erduhan Ertuğ Dinçer Yusuf Altunöz Arif Aksu Esra Akçalı |
| author_sort | Mustafa Ahmet Akçalı |
| collection | DOAJ |
| description | Background Heart failure (HF) has become a public healthcare concern with significant costs to countries because of the aging world population. Acute heart failure (AHF) is a common condition faced frequently in emergency departments, and patients often present to hospitals with complaints of breathlessness. The patient must be evaluated with anamnesis, physical examination, blood, and imaging results to diagnose AHF. Brain natriuretic peptide (BNP) is a widely accepted biomarker for the diagnosis of HF. Methods The files of the patients who applied to the emergency department with complaints of breathlessness were scanned, and BNP and urinary density (UD) levels were evaluated for the diagnosis of HF in patients. Results The results support that BNP is an effective biomarker in AHF, as is widely accepted. When the correlation between BNP and UD measurements was examined in the present study, a negative correlation was detected between the parameters. The results also suggested that low UD values may help diagnose AHF. Conclusion If similar results are obtained in prospective multicenter studies with the participation of more patients, UD value can be used as a biomarker for the diagnosis of AHF. |
| format | Article |
| id | doaj-art-a22655887706448e8b6d6f041f2cea71 |
| institution | Kabale University |
| issn | 2167-8359 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | PeerJ Inc. |
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| spelling | doaj-art-a22655887706448e8b6d6f041f2cea712025-01-22T15:05:22ZengPeerJ Inc.PeerJ2167-83592025-01-0113e1883610.7717/peerj.18836Evaluation of urinary density as a biomarker for the diagnosis of acute heart failureMustafa Ahmet Akçalı0Semih Çınar1Kemal Abid Tekin2Recep Murat Mert3Sena Erduhan4Ertuğ Dinçer5Yusuf Altunöz6Arif Aksu7Esra Akçalı8Department of Emergency Medicine, Ministry of Health Dogubayazit Dr Yasar Eryilmaz State Hospital, Ağrı, TurkeyDepartment of Emergency Medicine, Tekirdag Dr. Ismail Fehmi Cumalioglu City Hospital, Tekirdağ, TurkeyDepartment of Cardiology, Ministry of Health Dogubayazit Dr Yasar Eryilmaz State Hospital, Ağrı, TurkeyDepartment of Emergency Medicine, Ministry of Health Dogubayazit Dr Yasar Eryilmaz State Hospital, Ağrı, TurkeyDepartment of Medical Biochemistry, Dogubayazit Dr Yasar Eryilmaz State Hospital, Ağrı, TurkeyDepartment of Emergency Medicine, Ministry of Health Merzifon Kara Mustafa Pasa State Hospital, Amasya, TurkeyDepartment of Emergency Medicine, Sincan Nafiz Korez Education and Research Hospital, Ankara, TurkeyDepartment of Emergency Medicine, Health Science University Adana City Research and Training Hospital, Adana, TurkeyDepartment of Nephrology, Ministry of Health Tarsus State Hospital, Mersin, TurkeyBackground Heart failure (HF) has become a public healthcare concern with significant costs to countries because of the aging world population. Acute heart failure (AHF) is a common condition faced frequently in emergency departments, and patients often present to hospitals with complaints of breathlessness. The patient must be evaluated with anamnesis, physical examination, blood, and imaging results to diagnose AHF. Brain natriuretic peptide (BNP) is a widely accepted biomarker for the diagnosis of HF. Methods The files of the patients who applied to the emergency department with complaints of breathlessness were scanned, and BNP and urinary density (UD) levels were evaluated for the diagnosis of HF in patients. Results The results support that BNP is an effective biomarker in AHF, as is widely accepted. When the correlation between BNP and UD measurements was examined in the present study, a negative correlation was detected between the parameters. The results also suggested that low UD values may help diagnose AHF. Conclusion If similar results are obtained in prospective multicenter studies with the participation of more patients, UD value can be used as a biomarker for the diagnosis of AHF.https://peerj.com/articles/18836.pdfBreathlessnessEmergency medicineHeart failureNatriuretic peptidesUrinalysis |
| spellingShingle | Mustafa Ahmet Akçalı Semih Çınar Kemal Abid Tekin Recep Murat Mert Sena Erduhan Ertuğ Dinçer Yusuf Altunöz Arif Aksu Esra Akçalı Evaluation of urinary density as a biomarker for the diagnosis of acute heart failure PeerJ Breathlessness Emergency medicine Heart failure Natriuretic peptides Urinalysis |
| title | Evaluation of urinary density as a biomarker for the diagnosis of acute heart failure |
| title_full | Evaluation of urinary density as a biomarker for the diagnosis of acute heart failure |
| title_fullStr | Evaluation of urinary density as a biomarker for the diagnosis of acute heart failure |
| title_full_unstemmed | Evaluation of urinary density as a biomarker for the diagnosis of acute heart failure |
| title_short | Evaluation of urinary density as a biomarker for the diagnosis of acute heart failure |
| title_sort | evaluation of urinary density as a biomarker for the diagnosis of acute heart failure |
| topic | Breathlessness Emergency medicine Heart failure Natriuretic peptides Urinalysis |
| url | https://peerj.com/articles/18836.pdf |
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