Ovarian Carcinosarcoma and Its Association with Mature Cystic Teratoma and Primary Tubal Carcinoma
Introduction. Carcinosarcoma is an uncommon form of ovarian cancers, classified as being part of the group of mixed epithelial and mesenchymal tumors. The occurrence of carcinosarcoma in association with a mature cystic teratoma and synchronous tubal carcinoma is very rare. Case Report. A 69-year-ol...
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| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2016/2605045 |
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| author | Sunida Rewsuwan Nopporn Satabongkoch Prapaporn Suprasert Surapan Khunamornpong |
| author_facet | Sunida Rewsuwan Nopporn Satabongkoch Prapaporn Suprasert Surapan Khunamornpong |
| author_sort | Sunida Rewsuwan |
| collection | DOAJ |
| description | Introduction. Carcinosarcoma is an uncommon form of ovarian cancers, classified as being part of the group of mixed epithelial and mesenchymal tumors. The occurrence of carcinosarcoma in association with a mature cystic teratoma and synchronous tubal carcinoma is very rare. Case Report. A 69-year-old woman presented with a pelvic mass. An abdominal computerized tomographic scan detected a 15 cm right pelvic mass which was suggestive of malignant transformation of a dermoid cyst. Intraoperative, bilateral ovarian masses (left 10 cm and right 12 cm) with diffuse peritoneal metastatic nodules were identified. Histologically, the left ovarian mass was composed of 2 components including carcinosarcoma and mature cystic teratoma, whereas the right ovarian mass represented a mature cystic teratoma with serosal surface involvement of high-grade serous adenocarcinoma. The left fallopian tube was macroscopically unremarkable but contained a 5.0 mm focus of high-grade serous adenocarcinoma in the distal part, with adjacent serous tubal intraepithelial carcinoma. Conclusion. As the fallopian tube has recently been proposed to be an origin for a majority of pelvic or ovarian high-grade serous adenocarcinomas, tubal carcinoma may be the origin for ovarian carcinosarcomas through an epithelial-mesenchymal transition. The coexistence of ovarian carcinosarcoma and teratoma in the present case should represent a collision tumor. |
| format | Article |
| id | doaj-art-a216da9bd06745ed95cfb5338645fc3a |
| institution | Kabale University |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
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| series | Case Reports in Pathology |
| spelling | doaj-art-a216da9bd06745ed95cfb5338645fc3a2025-02-03T01:11:32ZengWileyCase Reports in Pathology2090-67812090-679X2016-01-01201610.1155/2016/26050452605045Ovarian Carcinosarcoma and Its Association with Mature Cystic Teratoma and Primary Tubal CarcinomaSunida Rewsuwan0Nopporn Satabongkoch1Prapaporn Suprasert2Surapan Khunamornpong3Department of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, ThailandIntroduction. Carcinosarcoma is an uncommon form of ovarian cancers, classified as being part of the group of mixed epithelial and mesenchymal tumors. The occurrence of carcinosarcoma in association with a mature cystic teratoma and synchronous tubal carcinoma is very rare. Case Report. A 69-year-old woman presented with a pelvic mass. An abdominal computerized tomographic scan detected a 15 cm right pelvic mass which was suggestive of malignant transformation of a dermoid cyst. Intraoperative, bilateral ovarian masses (left 10 cm and right 12 cm) with diffuse peritoneal metastatic nodules were identified. Histologically, the left ovarian mass was composed of 2 components including carcinosarcoma and mature cystic teratoma, whereas the right ovarian mass represented a mature cystic teratoma with serosal surface involvement of high-grade serous adenocarcinoma. The left fallopian tube was macroscopically unremarkable but contained a 5.0 mm focus of high-grade serous adenocarcinoma in the distal part, with adjacent serous tubal intraepithelial carcinoma. Conclusion. As the fallopian tube has recently been proposed to be an origin for a majority of pelvic or ovarian high-grade serous adenocarcinomas, tubal carcinoma may be the origin for ovarian carcinosarcomas through an epithelial-mesenchymal transition. The coexistence of ovarian carcinosarcoma and teratoma in the present case should represent a collision tumor.http://dx.doi.org/10.1155/2016/2605045 |
| spellingShingle | Sunida Rewsuwan Nopporn Satabongkoch Prapaporn Suprasert Surapan Khunamornpong Ovarian Carcinosarcoma and Its Association with Mature Cystic Teratoma and Primary Tubal Carcinoma Case Reports in Pathology |
| title | Ovarian Carcinosarcoma and Its Association with Mature Cystic Teratoma and Primary Tubal Carcinoma |
| title_full | Ovarian Carcinosarcoma and Its Association with Mature Cystic Teratoma and Primary Tubal Carcinoma |
| title_fullStr | Ovarian Carcinosarcoma and Its Association with Mature Cystic Teratoma and Primary Tubal Carcinoma |
| title_full_unstemmed | Ovarian Carcinosarcoma and Its Association with Mature Cystic Teratoma and Primary Tubal Carcinoma |
| title_short | Ovarian Carcinosarcoma and Its Association with Mature Cystic Teratoma and Primary Tubal Carcinoma |
| title_sort | ovarian carcinosarcoma and its association with mature cystic teratoma and primary tubal carcinoma |
| url | http://dx.doi.org/10.1155/2016/2605045 |
| work_keys_str_mv | AT sunidarewsuwan ovariancarcinosarcomaanditsassociationwithmaturecysticteratomaandprimarytubalcarcinoma AT noppornsatabongkoch ovariancarcinosarcomaanditsassociationwithmaturecysticteratomaandprimarytubalcarcinoma AT prapapornsuprasert ovariancarcinosarcomaanditsassociationwithmaturecysticteratomaandprimarytubalcarcinoma AT surapankhunamornpong ovariancarcinosarcomaanditsassociationwithmaturecysticteratomaandprimarytubalcarcinoma |