MicroRNAs in Diabetic Kidney Disease
Rapid growth of diabetes and diabetic kidney disease exerts a great burden on society. Owing to the lack of effective treatments for diabetic kidney disease, treatment relies on drugs that either reduces its progression or involve renal replacement therapies, such as dialysis and kidney transplantat...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2014/593956 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832565463941382144 |
|---|---|
| author | Rong Li Arthur C. K. Chung Xueqing Yu Hui Y. Lan |
| author_facet | Rong Li Arthur C. K. Chung Xueqing Yu Hui Y. Lan |
| author_sort | Rong Li |
| collection | DOAJ |
| description | Rapid growth of diabetes and diabetic kidney disease exerts a great burden on society. Owing to the lack of effective treatments for diabetic kidney disease, treatment relies on drugs that either reduces its progression or involve renal replacement therapies, such as dialysis and kidney transplantation. It is urgent to search for biomarkers for early diagnosis and effective therapy. The discovery of microRNAs had lead to a new era of post-transcriptional regulators of gene expression. Studies from cells, experimental animal models and patients under diabetic conditions demonstrate that expression patterns of microRNAs are altered during the progression of diabetic kidney disease. Functional studies indicate that the ability of microRNAs to bind 3′ untranslated region of messenger RNA not only shows their capability to regulate expression of target genes, but also their therapeutic potential to diabetic kidney disease. The presence of microRNAs in plasma, serum, and urine has been shown to be possible biomarkers in diabetic kidney disease. Therefore, identification of the pathogenic role of microRNAs possesses an important clinical impact in terms of prevention and treatment of progression in diabetic kidney disease because it allows us to design novel and specific therapies and diagnostic tools for diabetic kidney disease. |
| format | Article |
| id | doaj-art-a216b3f193224f4280f6148be513bb2b |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-a216b3f193224f4280f6148be513bb2b2025-02-03T01:07:32ZengWileyInternational Journal of Endocrinology1687-83371687-83452014-01-01201410.1155/2014/593956593956MicroRNAs in Diabetic Kidney DiseaseRong Li0Arthur C. K. Chung1Xueqing Yu2Hui Y. Lan3Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, Hong KongLi Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, Hong KongDepartment of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaLi Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, Hong KongRapid growth of diabetes and diabetic kidney disease exerts a great burden on society. Owing to the lack of effective treatments for diabetic kidney disease, treatment relies on drugs that either reduces its progression or involve renal replacement therapies, such as dialysis and kidney transplantation. It is urgent to search for biomarkers for early diagnosis and effective therapy. The discovery of microRNAs had lead to a new era of post-transcriptional regulators of gene expression. Studies from cells, experimental animal models and patients under diabetic conditions demonstrate that expression patterns of microRNAs are altered during the progression of diabetic kidney disease. Functional studies indicate that the ability of microRNAs to bind 3′ untranslated region of messenger RNA not only shows their capability to regulate expression of target genes, but also their therapeutic potential to diabetic kidney disease. The presence of microRNAs in plasma, serum, and urine has been shown to be possible biomarkers in diabetic kidney disease. Therefore, identification of the pathogenic role of microRNAs possesses an important clinical impact in terms of prevention and treatment of progression in diabetic kidney disease because it allows us to design novel and specific therapies and diagnostic tools for diabetic kidney disease.http://dx.doi.org/10.1155/2014/593956 |
| spellingShingle | Rong Li Arthur C. K. Chung Xueqing Yu Hui Y. Lan MicroRNAs in Diabetic Kidney Disease International Journal of Endocrinology |
| title | MicroRNAs in Diabetic Kidney Disease |
| title_full | MicroRNAs in Diabetic Kidney Disease |
| title_fullStr | MicroRNAs in Diabetic Kidney Disease |
| title_full_unstemmed | MicroRNAs in Diabetic Kidney Disease |
| title_short | MicroRNAs in Diabetic Kidney Disease |
| title_sort | micrornas in diabetic kidney disease |
| url | http://dx.doi.org/10.1155/2014/593956 |
| work_keys_str_mv | AT rongli micrornasindiabetickidneydisease AT arthurckchung micrornasindiabetickidneydisease AT xueqingyu micrornasindiabetickidneydisease AT huiylan micrornasindiabetickidneydisease |