Relationship of asprosin and diabetes: a meta-analysis
Abstract Background Diabetes characterized by chronic hyperglycemia, has become a serious hazard to human health in the recent decades. Previous research suggests that asprosin may contribute to the development of diabetes by regulating glucose homeostasis, appetite, insulin secretion, and insulin s...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | BMC Endocrine Disorders |
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| Online Access: | https://doi.org/10.1186/s12902-025-01843-1 |
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| author | Xiandong Zeng Xin Sun Wei He Jing Xie Caihong Xin |
| author_facet | Xiandong Zeng Xin Sun Wei He Jing Xie Caihong Xin |
| author_sort | Xiandong Zeng |
| collection | DOAJ |
| description | Abstract Background Diabetes characterized by chronic hyperglycemia, has become a serious hazard to human health in the recent decades. Previous research suggests that asprosin may contribute to the development of diabetes by regulating glucose homeostasis, appetite, insulin secretion, and insulin sensitivity. Although some studies have shown that asprosin levels are higher in patients with diabetes than in healthy individuals, the association between asprosin levels and diabetes remains controversial. Aim This meta-analysis aimed to assess asprosin levels in patients with diabetes and in healthy individuals. Methods We searched the following electronic databases: Web of Science, ScienceDirect, PubMed, and Willy. The title or abstract uses the following search term: “diabetes” is used in combination with the term “asprosin.” The meta-analysis results are presented as standardized mean differences (SMDs) with corresponding 95% confidence intervals (CIs). Results Fourteen articles were included in this meta-analysis. In our meta-analysis, the asprosin level in patients with diabetes was significantly higher than that in healthy controls (SMD: 0.95, 95% CI [0.66, 1.24]). Moreover, there was a significant difference in the asprosin levels between patients with diabetes without complication and those with complication (SMD: 0.81, 95% CI [0.33, 1.29]). Conclusions This systematic review is the first to evaluate the relationship between asprosin levels and diabetes. The asprosin levels were significantly higher in patients with diabetes. Clinical trial number Not applicable. |
| format | Article |
| id | doaj-art-a20039e1744748b08df5059fe29f0952 |
| institution | Kabale University |
| issn | 1472-6823 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj-art-a20039e1744748b08df5059fe29f09522025-01-26T12:37:33ZengBMCBMC Endocrine Disorders1472-68232025-01-012511910.1186/s12902-025-01843-1Relationship of asprosin and diabetes: a meta-analysisXiandong Zeng0Xin Sun1Wei He2Jing Xie3Caihong Xin4Department of Oncological Surgery, Fourth People’s Hospital of ShenyangDepartment of Endocrinology and Metabolism, First Affiliated Hospital of Soochow UniversityDepartment of Endocrinology and Metabolism, People’s Hospital of Liaoning ProvinceDepartment of Endocrinology and Metabolism, First Affiliated Hospital of Soochow UniversityDepartment of Endocrinology and Metabolism, Fourth People’s Hospital of ShenyangAbstract Background Diabetes characterized by chronic hyperglycemia, has become a serious hazard to human health in the recent decades. Previous research suggests that asprosin may contribute to the development of diabetes by regulating glucose homeostasis, appetite, insulin secretion, and insulin sensitivity. Although some studies have shown that asprosin levels are higher in patients with diabetes than in healthy individuals, the association between asprosin levels and diabetes remains controversial. Aim This meta-analysis aimed to assess asprosin levels in patients with diabetes and in healthy individuals. Methods We searched the following electronic databases: Web of Science, ScienceDirect, PubMed, and Willy. The title or abstract uses the following search term: “diabetes” is used in combination with the term “asprosin.” The meta-analysis results are presented as standardized mean differences (SMDs) with corresponding 95% confidence intervals (CIs). Results Fourteen articles were included in this meta-analysis. In our meta-analysis, the asprosin level in patients with diabetes was significantly higher than that in healthy controls (SMD: 0.95, 95% CI [0.66, 1.24]). Moreover, there was a significant difference in the asprosin levels between patients with diabetes without complication and those with complication (SMD: 0.81, 95% CI [0.33, 1.29]). Conclusions This systematic review is the first to evaluate the relationship between asprosin levels and diabetes. The asprosin levels were significantly higher in patients with diabetes. Clinical trial number Not applicable.https://doi.org/10.1186/s12902-025-01843-1AsprosinDiabetesMeta-analysis |
| spellingShingle | Xiandong Zeng Xin Sun Wei He Jing Xie Caihong Xin Relationship of asprosin and diabetes: a meta-analysis BMC Endocrine Disorders Asprosin Diabetes Meta-analysis |
| title | Relationship of asprosin and diabetes: a meta-analysis |
| title_full | Relationship of asprosin and diabetes: a meta-analysis |
| title_fullStr | Relationship of asprosin and diabetes: a meta-analysis |
| title_full_unstemmed | Relationship of asprosin and diabetes: a meta-analysis |
| title_short | Relationship of asprosin and diabetes: a meta-analysis |
| title_sort | relationship of asprosin and diabetes a meta analysis |
| topic | Asprosin Diabetes Meta-analysis |
| url | https://doi.org/10.1186/s12902-025-01843-1 |
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