FTO SUMOylation regulates the differentiation of bone marrow mesenchymal stromal cells in inflammatory bowel disease-induced bone loss

FTO SUMOylation regulates the differentiation of bone marrow mesenchymal stromal cells in inflammatory bowel disease-induced bone loss

Summary: The gut-bone axis is critical for body homeostasis, but bone loss often complicates inflammatory bowel disease (IBD) with unclear mechanisms. Here, we found that IBD mice showed reduced bone formation, with bone marrow mesenchymal stromal cells (BMSCs) favoring adipogenesis over osteogenesi...

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Bibliographic Details
Main Authors: Haoming Wang, Jiandong Guo, Lijun Li, Hongwei Xie, Jiateng Zhang, Wanda Zhang, Ying Liu, Qingliang Ma, Shiyu Wang, Putao Yuan, Zhiwei Jie, Shunwu Fan, Ziang Xie
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Cell Reports
Subjects:
CP: Stem cell research
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725007247
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