Detection of Nosocomial Respiratory Infections among Hospitalized Patients in Intensive Care Unit: a Survey in Northern Iran
Introduction: Nosocomial respiratory infections are a significant cause of mortality in hospitalized patients in Middle East countries. This study assesses the prevalence of nosocomial respiratory infection and associated factors as a tool for early diagnosis among intensive care unit (ICU) patie...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Pasteur Institute of Iran
2022-09-01
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| Series: | Journal of Medical Microbiology and Infectious Diseases |
| Subjects: | |
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| Summary: | Introduction: Nosocomial respiratory infections are a significant cause of
mortality in hospitalized patients in Middle East countries. This study assesses
the prevalence of nosocomial respiratory infection and associated factors as a
tool for early diagnosis among intensive care unit (ICU) patients at risk for
mortality. Methods: From January to November 2021, 357 patients with more
than 72 h hospitalization in ICU were monitored. Respiratory samples were
examined for the presence of microbial isolates using clinical microbiology
procedures based upon microscopic morphology, cultural and PCR methods.
Demographic data were collected, including age, gender, date of hospitalization,
underlying diseases, date of death, and laboratory data. Results: Out of fiftythree
positive cultures, 18 samples (34%) were positive for fungal isolates, and
the rest were positive for bacterial isolates. The most common bacterial and
fungal isolates were Streptococcus pyogenes (17.9%) and Candida albicans
(22.5%). Of the infected patients, 67.9% were male, 39.62 % had kidney
diseases, and 15.09% died due to nosocomial infections. The results also showed
that the tumor necrosis factor α and complement component 3 levels were
significantly associated with the incidence of respiratory fungal or bacterial
infections (P<0.05). Conclusions: The rate of respiratory nosocomial infection
in ICU patients was high. It is essential to implement control measures such as
managing the length of hospital stay and examining the patient's immune factors
to reduce the risk of these infections in ICU patients. Also, ICU patients should
be prescribed appropriate antibiotics to prevent respiratory infections. |
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| ISSN: | 2345-5349 2345-5330 |