Dental Mesenchymal Stem/Stromal Cells and Their Exosomes
Stem cells derived from human dental pulp tissue (DP-MSC) differ from the other mesenchymal stem cells prepared from bone marrow or adipose tissue due to their embryonic origin from the neural crest and are of special interest because of their neurotropic character. Furthermore, the therapeutic pote...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2018/8973613 |
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| author | Peter Stanko Ursula Altanerova Jana Jakubechova Vanda Repiska Cestmir Altaner |
| author_facet | Peter Stanko Ursula Altanerova Jana Jakubechova Vanda Repiska Cestmir Altaner |
| author_sort | Peter Stanko |
| collection | DOAJ |
| description | Stem cells derived from human dental pulp tissue (DP-MSC) differ from the other mesenchymal stem cells prepared from bone marrow or adipose tissue due to their embryonic origin from the neural crest and are of special interest because of their neurotropic character. Furthermore, the therapeutic potential of DP-MSCs is realized through paracrine action of extracellularly released components, for which exosomes play an important role. In this review, we intend to explore the properties of these cells with an emphasis on exosomes. The therapeutic applicability of these cells and exosomes in dental practice, neurodegenerative diseases, and many other difficultly treatable diseases, like myocardial infarction, focal cerebral ischemia, acute lung or brain injury, acute respiratory distress syndrome, acute inflammation, and several others is concisely covered. The use of cellular exosomes as an important diagnostic marker and indicator of targeted cancer therapies is also discussed, while the importance of stem cells from human exfoliated deciduous teeth as a source of evolutionally young cells for future regenerative therapies is stressed. We conclude that exosomes derived from these cells are potent therapeutic tools for regenerative medicine in the near future as clinical administration of DP-MSC-conditioned medium and/or exosomes is safer and more practical than stem cells. |
| format | Article |
| id | doaj-art-a1ee6486f45d4f358fdb4bb7e0dd3d71 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-a1ee6486f45d4f358fdb4bb7e0dd3d712025-02-03T05:58:05ZengWileyStem Cells International1687-966X1687-96782018-01-01201810.1155/2018/89736138973613Dental Mesenchymal Stem/Stromal Cells and Their ExosomesPeter Stanko0Ursula Altanerova1Jana Jakubechova2Vanda Repiska3Cestmir Altaner4Department of Stomatology and Maxillofacial Surgery, Faculty of Medicine, Comenius University in Bratislava, Bratislava, SlovakiaDepartment of Stem Cell Preparation, St. Elisabeth Cancer Institute, Bratislava, SlovakiaDepartment of Stem Cell Preparation, St. Elisabeth Cancer Institute, Bratislava, SlovakiaInstitute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University in Bratislava, Bratislava, SlovakiaDepartment of Stem Cell Preparation, St. Elisabeth Cancer Institute, Bratislava, SlovakiaStem cells derived from human dental pulp tissue (DP-MSC) differ from the other mesenchymal stem cells prepared from bone marrow or adipose tissue due to their embryonic origin from the neural crest and are of special interest because of their neurotropic character. Furthermore, the therapeutic potential of DP-MSCs is realized through paracrine action of extracellularly released components, for which exosomes play an important role. In this review, we intend to explore the properties of these cells with an emphasis on exosomes. The therapeutic applicability of these cells and exosomes in dental practice, neurodegenerative diseases, and many other difficultly treatable diseases, like myocardial infarction, focal cerebral ischemia, acute lung or brain injury, acute respiratory distress syndrome, acute inflammation, and several others is concisely covered. The use of cellular exosomes as an important diagnostic marker and indicator of targeted cancer therapies is also discussed, while the importance of stem cells from human exfoliated deciduous teeth as a source of evolutionally young cells for future regenerative therapies is stressed. We conclude that exosomes derived from these cells are potent therapeutic tools for regenerative medicine in the near future as clinical administration of DP-MSC-conditioned medium and/or exosomes is safer and more practical than stem cells.http://dx.doi.org/10.1155/2018/8973613 |
| spellingShingle | Peter Stanko Ursula Altanerova Jana Jakubechova Vanda Repiska Cestmir Altaner Dental Mesenchymal Stem/Stromal Cells and Their Exosomes Stem Cells International |
| title | Dental Mesenchymal Stem/Stromal Cells and Their Exosomes |
| title_full | Dental Mesenchymal Stem/Stromal Cells and Their Exosomes |
| title_fullStr | Dental Mesenchymal Stem/Stromal Cells and Their Exosomes |
| title_full_unstemmed | Dental Mesenchymal Stem/Stromal Cells and Their Exosomes |
| title_short | Dental Mesenchymal Stem/Stromal Cells and Their Exosomes |
| title_sort | dental mesenchymal stem stromal cells and their exosomes |
| url | http://dx.doi.org/10.1155/2018/8973613 |
| work_keys_str_mv | AT peterstanko dentalmesenchymalstemstromalcellsandtheirexosomes AT ursulaaltanerova dentalmesenchymalstemstromalcellsandtheirexosomes AT janajakubechova dentalmesenchymalstemstromalcellsandtheirexosomes AT vandarepiska dentalmesenchymalstemstromalcellsandtheirexosomes AT cestmiraltaner dentalmesenchymalstemstromalcellsandtheirexosomes |