Gene Therapy with Endogenous Inhibitors of Angiogenesis for Neovascular Age-Related Macular Degeneration: Beyond Anti-VEGF Therapy
Age-related macular degeneration (AMD) is the leading cause of substantial and irreversible vision loss amongst elderly populations in industrialized countries. The advanced neovascular (or “wet”) form of the disease is responsible for severe and aggressive loss of central vision. Current treatments...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2015/201726 |
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| author | Selwyn M. Prea Elsa C. Chan Gregory J. Dusting Algis J. Vingrys Bang V. Bui Guei-Sheung Liu |
| author_facet | Selwyn M. Prea Elsa C. Chan Gregory J. Dusting Algis J. Vingrys Bang V. Bui Guei-Sheung Liu |
| author_sort | Selwyn M. Prea |
| collection | DOAJ |
| description | Age-related macular degeneration (AMD) is the leading cause of substantial and irreversible vision loss amongst elderly populations in industrialized countries. The advanced neovascular (or “wet”) form of the disease is responsible for severe and aggressive loss of central vision. Current treatments aim to seal off leaky blood vessels via laser therapy or to suppress vessel leakage and neovascular growth through intraocular injections of antibodies that target vascular endothelial growth factor (VEGF). However, the long-term success of anti-VEGF therapy can be hampered by limitations such as low or variable efficacy, high frequency of administration (usually monthly), potentially serious side effects, and, most importantly, loss of efficacy with prolonged treatment. Gene transfer of endogenous antiangiogenic proteins is an alternative approach that has the potential to provide long-term suppression of neovascularization and/or excessive vascular leakage in the eye. Preclinical studies of gene transfer in a large animal model have provided impressive preliminary results with a number of transgenes. In addition, a clinical trial in patients suffering from advanced neovascular AMD has provided proof-of-concept for successful gene transfer. In this mini review, we summarize current theories pertaining to the application of gene therapy for neovascular AMD and the potential benefits when used in conjunction with endogenous antiangiogenic proteins. |
| format | Article |
| id | doaj-art-a1ed86332f234383bd82ad6b5fa6276a |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-a1ed86332f234383bd82ad6b5fa6276a2025-02-03T07:24:59ZengWileyJournal of Ophthalmology2090-004X2090-00582015-01-01201510.1155/2015/201726201726Gene Therapy with Endogenous Inhibitors of Angiogenesis for Neovascular Age-Related Macular Degeneration: Beyond Anti-VEGF TherapySelwyn M. Prea0Elsa C. Chan1Gregory J. Dusting2Algis J. Vingrys3Bang V. Bui4Guei-Sheung Liu5Department of Optometry & Vision Sciences, University of Melbourne, 4th Floor, Alice Hoy Building, 162 Monash Road, Parkville, VIC 3010, AustraliaCentre for Eye Research Australia, Level 1, 32 Gisborne Street, East Melbourne, VIC 3002, AustraliaCentre for Eye Research Australia, Level 1, 32 Gisborne Street, East Melbourne, VIC 3002, AustraliaDepartment of Optometry & Vision Sciences, University of Melbourne, 4th Floor, Alice Hoy Building, 162 Monash Road, Parkville, VIC 3010, AustraliaDepartment of Optometry & Vision Sciences, University of Melbourne, 4th Floor, Alice Hoy Building, 162 Monash Road, Parkville, VIC 3010, AustraliaCentre for Eye Research Australia, Level 1, 32 Gisborne Street, East Melbourne, VIC 3002, AustraliaAge-related macular degeneration (AMD) is the leading cause of substantial and irreversible vision loss amongst elderly populations in industrialized countries. The advanced neovascular (or “wet”) form of the disease is responsible for severe and aggressive loss of central vision. Current treatments aim to seal off leaky blood vessels via laser therapy or to suppress vessel leakage and neovascular growth through intraocular injections of antibodies that target vascular endothelial growth factor (VEGF). However, the long-term success of anti-VEGF therapy can be hampered by limitations such as low or variable efficacy, high frequency of administration (usually monthly), potentially serious side effects, and, most importantly, loss of efficacy with prolonged treatment. Gene transfer of endogenous antiangiogenic proteins is an alternative approach that has the potential to provide long-term suppression of neovascularization and/or excessive vascular leakage in the eye. Preclinical studies of gene transfer in a large animal model have provided impressive preliminary results with a number of transgenes. In addition, a clinical trial in patients suffering from advanced neovascular AMD has provided proof-of-concept for successful gene transfer. In this mini review, we summarize current theories pertaining to the application of gene therapy for neovascular AMD and the potential benefits when used in conjunction with endogenous antiangiogenic proteins.http://dx.doi.org/10.1155/2015/201726 |
| spellingShingle | Selwyn M. Prea Elsa C. Chan Gregory J. Dusting Algis J. Vingrys Bang V. Bui Guei-Sheung Liu Gene Therapy with Endogenous Inhibitors of Angiogenesis for Neovascular Age-Related Macular Degeneration: Beyond Anti-VEGF Therapy Journal of Ophthalmology |
| title | Gene Therapy with Endogenous Inhibitors of Angiogenesis for Neovascular Age-Related Macular Degeneration: Beyond Anti-VEGF Therapy |
| title_full | Gene Therapy with Endogenous Inhibitors of Angiogenesis for Neovascular Age-Related Macular Degeneration: Beyond Anti-VEGF Therapy |
| title_fullStr | Gene Therapy with Endogenous Inhibitors of Angiogenesis for Neovascular Age-Related Macular Degeneration: Beyond Anti-VEGF Therapy |
| title_full_unstemmed | Gene Therapy with Endogenous Inhibitors of Angiogenesis for Neovascular Age-Related Macular Degeneration: Beyond Anti-VEGF Therapy |
| title_short | Gene Therapy with Endogenous Inhibitors of Angiogenesis for Neovascular Age-Related Macular Degeneration: Beyond Anti-VEGF Therapy |
| title_sort | gene therapy with endogenous inhibitors of angiogenesis for neovascular age related macular degeneration beyond anti vegf therapy |
| url | http://dx.doi.org/10.1155/2015/201726 |
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