Multiple Myeloma in a Patient with ANKRD26-Related Thrombocytopenia Successfully Treated with Combination Therapy and Autologous Stem Cell Transplant
Ankyrin repeat domain-containing protein 26- (ANKRD26-) related thrombocytopenia is a rare, autosomal dominant condition caused by ANKRD26 gene mutation. ANKRD26-related thrombocytopenia is characterized by moderate thrombocytopenia with minimal bleeding, normal platelet size, and dysmegakaryopoiesi...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2019/9357572 |
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| author | Muhammad Husnain Trent Wang Maikel Valdes James Hoffman Lazaros Lekakis |
| author_facet | Muhammad Husnain Trent Wang Maikel Valdes James Hoffman Lazaros Lekakis |
| author_sort | Muhammad Husnain |
| collection | DOAJ |
| description | Ankyrin repeat domain-containing protein 26- (ANKRD26-) related thrombocytopenia is a rare, autosomal dominant condition caused by ANKRD26 gene mutation. ANKRD26-related thrombocytopenia is characterized by moderate thrombocytopenia with minimal bleeding, normal platelet size, and dysmegakaryopoiesis on bone marrow evaluation. ANKRD26 mutation has been previously associated with myeloid malignancies, including acute myeloid leukemia, myelodysplastic syndrome, and chronic myeloid leukemia. We report the first case of multiple myeloma in a patient with ANKRD26 related thrombocytopenia. The patient was successfully treated with contemporary combination therapy followed by melphalan-conditioned autologous stem cell transplant for his multiple myeloma despite preexisting thrombocytopenia. |
| format | Article |
| id | doaj-art-a1eaacfbc3f54da19c34065b57caddd4 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-a1eaacfbc3f54da19c34065b57caddd42025-02-03T01:22:02ZengWileyCase Reports in Hematology2090-65602090-65792019-01-01201910.1155/2019/93575729357572Multiple Myeloma in a Patient with ANKRD26-Related Thrombocytopenia Successfully Treated with Combination Therapy and Autologous Stem Cell TransplantMuhammad Husnain0Trent Wang1Maikel Valdes2James Hoffman3Lazaros Lekakis4Division of Hematology/Oncology, Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL, USADivision of Hematology/Oncology, Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL, USASylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USADivision of Hematology/Oncology, Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL, USADivision of Hematology/Oncology, Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL, USAAnkyrin repeat domain-containing protein 26- (ANKRD26-) related thrombocytopenia is a rare, autosomal dominant condition caused by ANKRD26 gene mutation. ANKRD26-related thrombocytopenia is characterized by moderate thrombocytopenia with minimal bleeding, normal platelet size, and dysmegakaryopoiesis on bone marrow evaluation. ANKRD26 mutation has been previously associated with myeloid malignancies, including acute myeloid leukemia, myelodysplastic syndrome, and chronic myeloid leukemia. We report the first case of multiple myeloma in a patient with ANKRD26 related thrombocytopenia. The patient was successfully treated with contemporary combination therapy followed by melphalan-conditioned autologous stem cell transplant for his multiple myeloma despite preexisting thrombocytopenia.http://dx.doi.org/10.1155/2019/9357572 |
| spellingShingle | Muhammad Husnain Trent Wang Maikel Valdes James Hoffman Lazaros Lekakis Multiple Myeloma in a Patient with ANKRD26-Related Thrombocytopenia Successfully Treated with Combination Therapy and Autologous Stem Cell Transplant Case Reports in Hematology |
| title | Multiple Myeloma in a Patient with ANKRD26-Related Thrombocytopenia Successfully Treated with Combination Therapy and Autologous Stem Cell Transplant |
| title_full | Multiple Myeloma in a Patient with ANKRD26-Related Thrombocytopenia Successfully Treated with Combination Therapy and Autologous Stem Cell Transplant |
| title_fullStr | Multiple Myeloma in a Patient with ANKRD26-Related Thrombocytopenia Successfully Treated with Combination Therapy and Autologous Stem Cell Transplant |
| title_full_unstemmed | Multiple Myeloma in a Patient with ANKRD26-Related Thrombocytopenia Successfully Treated with Combination Therapy and Autologous Stem Cell Transplant |
| title_short | Multiple Myeloma in a Patient with ANKRD26-Related Thrombocytopenia Successfully Treated with Combination Therapy and Autologous Stem Cell Transplant |
| title_sort | multiple myeloma in a patient with ankrd26 related thrombocytopenia successfully treated with combination therapy and autologous stem cell transplant |
| url | http://dx.doi.org/10.1155/2019/9357572 |
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