Role of noncoding RNA as a pacemaker in cancer stem cell regulation: a review article
Abstract Accumulated evidence supported the crucial role of a tiny population of cells within the tumor called cancer stem cells (CSCs) in cancer origination, and proliferation. Additionally, these cells are distinguished by their self-renewal, differentiation, and therapeutic resistance capabilitie...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2025-03-01
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| Series: | Journal of the Egyptian National Cancer Institute |
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| Online Access: | https://doi.org/10.1186/s43046-025-00266-2 |
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| _version_ | 1850208487777239040 |
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| author | Yasmin M. Attia Samer A. Tadros Sally A. Fahim Doaa M. Badr |
| author_facet | Yasmin M. Attia Samer A. Tadros Sally A. Fahim Doaa M. Badr |
| author_sort | Yasmin M. Attia |
| collection | DOAJ |
| description | Abstract Accumulated evidence supported the crucial role of a tiny population of cells within the tumor called cancer stem cells (CSCs) in cancer origination, and proliferation. Additionally, these cells are distinguished by their self-renewal, differentiation, and therapeutic resistance capabilities. Interestingly, many studies recorded dysregulation of different types of noncoding RNAs, such as microRNA (miRNA) and long non-coding RNA (LncRNA), in cancer cells as well as CSCs. Moreover, several studies also supported the regulation of the transcription factors and signaling pathways required for CSC progression by these noncoding RNAs. However, the exact biological functions of all these noncoding RNAs are not well understood yet. These findings are of great interest, implying usage of noncoding RNA as therapeutic tool to target these cells. In this review, we provide an insight into how noncoding RNAs regulate CSCs and how this correlation is manipulated to develop new therapies to eradicate cancer cells successfully. |
| format | Article |
| id | doaj-art-a1e52780d00b42f486d2b5a2cb2d433b |
| institution | OA Journals |
| issn | 2589-0409 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Journal of the Egyptian National Cancer Institute |
| spelling | doaj-art-a1e52780d00b42f486d2b5a2cb2d433b2025-08-20T02:10:14ZengSpringerOpenJournal of the Egyptian National Cancer Institute2589-04092025-03-0137111610.1186/s43046-025-00266-2Role of noncoding RNA as a pacemaker in cancer stem cell regulation: a review articleYasmin M. Attia0Samer A. Tadros1Sally A. Fahim2Doaa M. Badr3Pharmacology Unit, Cancer Biology Department, National Cancer Institute, Cairo UniversityDepartment of Biochemistry, Faculty of Pharmacy, 110123october University for Modern Sciences and Arts (MSA)Department of Biochemistry, School of Pharmacy, Newgiza University (NGU), NewgizaPharmacology Unit, Cancer Biology Department, National Cancer Institute, Cairo UniversityAbstract Accumulated evidence supported the crucial role of a tiny population of cells within the tumor called cancer stem cells (CSCs) in cancer origination, and proliferation. Additionally, these cells are distinguished by their self-renewal, differentiation, and therapeutic resistance capabilities. Interestingly, many studies recorded dysregulation of different types of noncoding RNAs, such as microRNA (miRNA) and long non-coding RNA (LncRNA), in cancer cells as well as CSCs. Moreover, several studies also supported the regulation of the transcription factors and signaling pathways required for CSC progression by these noncoding RNAs. However, the exact biological functions of all these noncoding RNAs are not well understood yet. These findings are of great interest, implying usage of noncoding RNA as therapeutic tool to target these cells. In this review, we provide an insight into how noncoding RNAs regulate CSCs and how this correlation is manipulated to develop new therapies to eradicate cancer cells successfully.https://doi.org/10.1186/s43046-025-00266-2CancerCancer stem cellsNon-coding RNAMicroRNALong non-coding RNA |
| spellingShingle | Yasmin M. Attia Samer A. Tadros Sally A. Fahim Doaa M. Badr Role of noncoding RNA as a pacemaker in cancer stem cell regulation: a review article Journal of the Egyptian National Cancer Institute Cancer Cancer stem cells Non-coding RNA MicroRNA Long non-coding RNA |
| title | Role of noncoding RNA as a pacemaker in cancer stem cell regulation: a review article |
| title_full | Role of noncoding RNA as a pacemaker in cancer stem cell regulation: a review article |
| title_fullStr | Role of noncoding RNA as a pacemaker in cancer stem cell regulation: a review article |
| title_full_unstemmed | Role of noncoding RNA as a pacemaker in cancer stem cell regulation: a review article |
| title_short | Role of noncoding RNA as a pacemaker in cancer stem cell regulation: a review article |
| title_sort | role of noncoding rna as a pacemaker in cancer stem cell regulation a review article |
| topic | Cancer Cancer stem cells Non-coding RNA MicroRNA Long non-coding RNA |
| url | https://doi.org/10.1186/s43046-025-00266-2 |
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