Insights Into Atorvastatin Pharmacokinetics in Rats Reveal Regulation of CYP3A1 by Humanization of SLCO2B1

Insights Into Atorvastatin Pharmacokinetics in Rats Reveal Regulation of CYP3A1 by Humanization of SLCO2B1

ABSTRACT The organic anion transporting polypeptide (OATP) 2B1 is expressed in pharmacokinetically relevant organs such as the liver, the kidney, and the small intestine and it is known to transport a broad range of substrates including statins. In pharmacokinetic studies applying two rat models—one...

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Main Authors:	Jonny Kinzi, Janine Hussner, Isabell Seibert, Marta Rysz, Valerio Taggi, Simone Zuercher, Annika Tillmann, Oliver Schwardt, Stefan Oswald, Daniel Ricklin, Henriette E. Meyer zu Schwabedissen
Format:	Article
Language:	English
Published:	Wiley 2025-08-01
Series:	Pharmacology Research & Perspectives
Online Access:	https://doi.org/10.1002/prp2.70133
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