End-to-end dataflow engineering framework of honey manufacturing from intermediates to process by TAS1R2@AuNPs/SPCE biosensor coupled with quality transfer principle
This study reported an original end-to-end dataflow engineering framework for the quality transfer principle to overcome the quality challenges in real-world honey manufacturing. Firstly, 650 pivotal data points of physical and chemical quality attributes from 65 batches of honey intermediates were...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co. Ltd.
2025-01-01
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| Series: | Fundamental Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667325822004174 |
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| author | Xiaoyan Hu Jingqi Zeng Lijuan Ma Xiaomeng Wang Jing Du Lu Yao Zhisheng Wu |
| author_facet | Xiaoyan Hu Jingqi Zeng Lijuan Ma Xiaomeng Wang Jing Du Lu Yao Zhisheng Wu |
| author_sort | Xiaoyan Hu |
| collection | DOAJ |
| description | This study reported an original end-to-end dataflow engineering framework for the quality transfer principle to overcome the quality challenges in real-world honey manufacturing. Firstly, 650 pivotal data points of physical and chemical quality attributes from 65 batches of honey intermediates were characterized through multiple sensors, which included rheological properties, acidity, moisture, and sugars. Furthermore, a hypersensitized TAS1R2@AuNPs/SPCE biosensor was developed to identify biological quality attributes of honey, the powerful affinities between honey intermediates and the TAS1R2 receptor were discovered (KD < 1 × 10−8 M), and the abnormal batches of B2, B23 and C23 were diagnosed by TAS1R2@AuNPs/SPCE biosensor and multivariable algorithm. Finally, the end-to-end dataflow containing physical, chemical and biological critical quality attributes was successfully established to interpret the quality transfer principle of honey manufacturing, which revealed that the front-end refining process was relatively unstable and the back-end refining process was a negligible influence on the quality of honey manufacturing. This framework embraces quality management, quality transfer, and biosensor information, which will contribute to discovering the quality transfer principle in industrial innovation for intelligent manufacturing. |
| format | Article |
| id | doaj-art-a1dc7692b2b746918f562d058a1d5460 |
| institution | Kabale University |
| issn | 2667-3258 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | KeAi Communications Co. Ltd. |
| record_format | Article |
| series | Fundamental Research |
| spelling | doaj-art-a1dc7692b2b746918f562d058a1d54602025-01-29T05:02:28ZengKeAi Communications Co. Ltd.Fundamental Research2667-32582025-01-0151407418End-to-end dataflow engineering framework of honey manufacturing from intermediates to process by TAS1R2@AuNPs/SPCE biosensor coupled with quality transfer principleXiaoyan Hu0Jingqi Zeng1Lijuan Ma2Xiaomeng Wang3Jing Du4Lu Yao5Zhisheng Wu6Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China; Engineering Research Center for Pharmaceutics of Chinese Materia Medica and New Drug Development, Ministry of Education, Beijing 100102, China; Beijing University of Chinese Medicine, Beijing 100102, ChinaFujian University of Traditional Chinese Medicine, Fuzhou 350122, China; Engineering Research Center for Pharmaceutics of Chinese Materia Medica and New Drug Development, Ministry of Education, Beijing 100102, China; Beijing University of Chinese Medicine, Beijing 100102, ChinaEngineering Research Center for Pharmaceutics of Chinese Materia Medica and New Drug Development, Ministry of Education, Beijing 100102, China; Beijing University of Chinese Medicine, Beijing 100102, ChinaEngineering Research Center for Pharmaceutics of Chinese Materia Medica and New Drug Development, Ministry of Education, Beijing 100102, China; Beijing University of Chinese Medicine, Beijing 100102, ChinaChina Beijing Tongrentang Group Co., Ltd. Beijing 100062, ChinaChina Beijing Tongrentang Group Co., Ltd. Beijing 100062, ChinaFujian University of Traditional Chinese Medicine, Fuzhou 350122, China; Engineering Research Center for Pharmaceutics of Chinese Materia Medica and New Drug Development, Ministry of Education, Beijing 100102, China; Beijing University of Chinese Medicine, Beijing 100102, China; Corresponding author.This study reported an original end-to-end dataflow engineering framework for the quality transfer principle to overcome the quality challenges in real-world honey manufacturing. Firstly, 650 pivotal data points of physical and chemical quality attributes from 65 batches of honey intermediates were characterized through multiple sensors, which included rheological properties, acidity, moisture, and sugars. Furthermore, a hypersensitized TAS1R2@AuNPs/SPCE biosensor was developed to identify biological quality attributes of honey, the powerful affinities between honey intermediates and the TAS1R2 receptor were discovered (KD < 1 × 10−8 M), and the abnormal batches of B2, B23 and C23 were diagnosed by TAS1R2@AuNPs/SPCE biosensor and multivariable algorithm. Finally, the end-to-end dataflow containing physical, chemical and biological critical quality attributes was successfully established to interpret the quality transfer principle of honey manufacturing, which revealed that the front-end refining process was relatively unstable and the back-end refining process was a negligible influence on the quality of honey manufacturing. This framework embraces quality management, quality transfer, and biosensor information, which will contribute to discovering the quality transfer principle in industrial innovation for intelligent manufacturing.http://www.sciencedirect.com/science/article/pii/S2667325822004174End-to-end dataflowQuality transfer principleCritical quality attributesBiosensorHoney manufacturing |
| spellingShingle | Xiaoyan Hu Jingqi Zeng Lijuan Ma Xiaomeng Wang Jing Du Lu Yao Zhisheng Wu End-to-end dataflow engineering framework of honey manufacturing from intermediates to process by TAS1R2@AuNPs/SPCE biosensor coupled with quality transfer principle Fundamental Research End-to-end dataflow Quality transfer principle Critical quality attributes Biosensor Honey manufacturing |
| title | End-to-end dataflow engineering framework of honey manufacturing from intermediates to process by TAS1R2@AuNPs/SPCE biosensor coupled with quality transfer principle |
| title_full | End-to-end dataflow engineering framework of honey manufacturing from intermediates to process by TAS1R2@AuNPs/SPCE biosensor coupled with quality transfer principle |
| title_fullStr | End-to-end dataflow engineering framework of honey manufacturing from intermediates to process by TAS1R2@AuNPs/SPCE biosensor coupled with quality transfer principle |
| title_full_unstemmed | End-to-end dataflow engineering framework of honey manufacturing from intermediates to process by TAS1R2@AuNPs/SPCE biosensor coupled with quality transfer principle |
| title_short | End-to-end dataflow engineering framework of honey manufacturing from intermediates to process by TAS1R2@AuNPs/SPCE biosensor coupled with quality transfer principle |
| title_sort | end to end dataflow engineering framework of honey manufacturing from intermediates to process by tas1r2 aunps spce biosensor coupled with quality transfer principle |
| topic | End-to-end dataflow Quality transfer principle Critical quality attributes Biosensor Honey manufacturing |
| url | http://www.sciencedirect.com/science/article/pii/S2667325822004174 |
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