Maximum Likelihood Inference for Univariate Delay Differential Equation Models with Multiple Delays

This article presents statistical inference methodology based on maximum likelihoods for delay differential equation models in the univariate setting. Maximum likelihood inference is obtained for single and multiple unknown delay parameters as well as other parameters of interest that govern the tra...

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Main Authors: Ahmed A. Mahmoud, Sarat C. Dass, Mohana S. Muthuvalu, Vijanth S. Asirvadam
Format: Article
Language:English
Published: Wiley 2017-01-01
Series:Complexity
Online Access:http://dx.doi.org/10.1155/2017/6148934
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author Ahmed A. Mahmoud
Sarat C. Dass
Mohana S. Muthuvalu
Vijanth S. Asirvadam
author_facet Ahmed A. Mahmoud
Sarat C. Dass
Mohana S. Muthuvalu
Vijanth S. Asirvadam
author_sort Ahmed A. Mahmoud
collection DOAJ
description This article presents statistical inference methodology based on maximum likelihoods for delay differential equation models in the univariate setting. Maximum likelihood inference is obtained for single and multiple unknown delay parameters as well as other parameters of interest that govern the trajectories of the delay differential equation models. The maximum likelihood estimator is obtained based on adaptive grid and Newton-Raphson algorithms. Our methodology estimates correctly the delay parameters as well as other unknown parameters (such as the initial starting values) of the dynamical system based on simulation data. We also develop methodology to compute the information matrix and confidence intervals for all unknown parameters based on the likelihood inferential framework. We present three illustrative examples related to biological systems. The computations have been carried out with help of mathematical software: MATLAB® 8.0 R2014b.
format Article
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institution Kabale University
issn 1076-2787
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language English
publishDate 2017-01-01
publisher Wiley
record_format Article
series Complexity
spelling doaj-art-a1c7471a8dbb483b9c63756a1df762052025-02-03T01:12:26ZengWileyComplexity1076-27871099-05262017-01-01201710.1155/2017/61489346148934Maximum Likelihood Inference for Univariate Delay Differential Equation Models with Multiple DelaysAhmed A. Mahmoud0Sarat C. Dass1Mohana S. Muthuvalu2Vijanth S. Asirvadam3Fundamental and Applied Sciences Department, Faculty of Science and Information Technology, Universiti Teknologi PETRONAS, 32610 Seri Iskandar, Perak, MalaysiaFundamental and Applied Sciences Department, Faculty of Science and Information Technology, Universiti Teknologi PETRONAS, 32610 Seri Iskandar, Perak, MalaysiaFundamental and Applied Sciences Department, Faculty of Science and Information Technology, Universiti Teknologi PETRONAS, 32610 Seri Iskandar, Perak, MalaysiaDepartment of Electrical and Electronic Engineering, Center for Intelligent Signal and Imaging Research (CISIR), Universiti Teknologi PETRONAS, 32610 Seri Iskandar, Perak, MalaysiaThis article presents statistical inference methodology based on maximum likelihoods for delay differential equation models in the univariate setting. Maximum likelihood inference is obtained for single and multiple unknown delay parameters as well as other parameters of interest that govern the trajectories of the delay differential equation models. The maximum likelihood estimator is obtained based on adaptive grid and Newton-Raphson algorithms. Our methodology estimates correctly the delay parameters as well as other unknown parameters (such as the initial starting values) of the dynamical system based on simulation data. We also develop methodology to compute the information matrix and confidence intervals for all unknown parameters based on the likelihood inferential framework. We present three illustrative examples related to biological systems. The computations have been carried out with help of mathematical software: MATLAB® 8.0 R2014b.http://dx.doi.org/10.1155/2017/6148934
spellingShingle Ahmed A. Mahmoud
Sarat C. Dass
Mohana S. Muthuvalu
Vijanth S. Asirvadam
Maximum Likelihood Inference for Univariate Delay Differential Equation Models with Multiple Delays
Complexity
title Maximum Likelihood Inference for Univariate Delay Differential Equation Models with Multiple Delays
title_full Maximum Likelihood Inference for Univariate Delay Differential Equation Models with Multiple Delays
title_fullStr Maximum Likelihood Inference for Univariate Delay Differential Equation Models with Multiple Delays
title_full_unstemmed Maximum Likelihood Inference for Univariate Delay Differential Equation Models with Multiple Delays
title_short Maximum Likelihood Inference for Univariate Delay Differential Equation Models with Multiple Delays
title_sort maximum likelihood inference for univariate delay differential equation models with multiple delays
url http://dx.doi.org/10.1155/2017/6148934
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