Distribution frequencies of KIR genes among the Korean, Manchu and Han ethnic groups in Jilin Province
Objective To provide foundational data for exploring the association between KIR genes and diseases by analyzing the frequency and polymorphism of killer-cell immunoglobulin-like receptor (KIR) genes in Han, Manchu and Korean populations in Jilin Province. Methods KIR gene typing was performed on 12...
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Institute of Blood Transfusion of Chinese Academy of Medical Sciences
2024-10-01
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| Series: | Zhongguo shuxue zazhi |
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| Online Access: | https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2024.10.007&lang=en |
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| author | HAN Yu YANG Fan LIU Lingling NIE Tingting YANG Xu JIAO Lixin |
| author_facet | HAN Yu YANG Fan LIU Lingling NIE Tingting YANG Xu JIAO Lixin |
| author_sort | HAN Yu |
| collection | DOAJ |
| description | Objective To provide foundational data for exploring the association between KIR genes and diseases by analyzing the frequency and polymorphism of killer-cell immunoglobulin-like receptor (KIR) genes in Han, Manchu and Korean populations in Jilin Province. Methods KIR gene typing was performed on 129 Manchu, 198 Korean and 201 Han individuals from Jilin using the polymerase chain reaction-sequence specific primers (PCR-SSP) technique. Results KIR3DL2, KIR3DL3, KIR3DP1 and KIR2DL4 were detected in all subjects. KIR2DL1, KIR2DL3, KIR2DS4, KIR3DL1 and KIR2DP1 genes had high detection frequencies, ranging from 93% to 98% across the three ethnic groups. In contrast, the detection rates of KIR2DL2, KIR2DL5, KIR3DS1, KIR2DS1, KIR2DS2, KIR2DS3 and KIR2DS5 were lower, ranging from 13% to 45%. Notably, the detection frequencies of KIR2DL5 (17.83%) and KIR2DS1 (17.83%) in the Manchu population were significantly lower than those in the Korean (42.93%, 47.47%) and Han (33.83%, 33.33%) populations in Jilin. The detection frequencies of KIR2DL5 (42.93%) and KIR2DS1 (47.47%) were significantly higher in the Korean population compared to the Han (33.83%, 33.33%) and Manchu (17.83%, 17.83%) population. The frequency of the KIRAA haplotype in the Han population was the highest among the three ethnic groups in Jilin at 61.19%, significantly higher than that in the Korean population (42.93%). Differences between the three groups were statistically significant (P<0.05), and remained significant after Bonferroni correction (Pc<0.05). Conclusion The distribution of KIR genes in the Korean, Manchu and Han population in Jilin reflects the polymorphism of KIR genes in the Chinese population and also showcases unique ethnic genetic and regional characteristics. |
| format | Article |
| id | doaj-art-a1bf12b07ab44c729f3e8ed8f624b6e5 |
| institution | OA Journals |
| issn | 1004-549X |
| language | zho |
| publishDate | 2024-10-01 |
| publisher | Institute of Blood Transfusion of Chinese Academy of Medical Sciences |
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| series | Zhongguo shuxue zazhi |
| spelling | doaj-art-a1bf12b07ab44c729f3e8ed8f624b6e52025-08-20T02:12:11ZzhoInstitute of Blood Transfusion of Chinese Academy of Medical SciencesZhongguo shuxue zazhi1004-549X2024-10-0137101132113610.13303/j.cjbt.issn.1004-549x.2024.10.0071004-549X(2024)10-1132-05Distribution frequencies of KIR genes among the Korean, Manchu and Han ethnic groups in Jilin ProvinceHAN Yu0YANG Fan1LIU Lingling2NIE Tingting3YANG Xu4JIAO Lixin5Institution of Blood Transfusion, Changchun Central Blood Station, Changchun 130033, ChinaInstitution of Blood Transfusion, Changchun Central Blood Station, Changchun 130033, ChinaInstitution of Blood Transfusion, Changchun Central Blood Station, Changchun 130033, ChinaInstitution of Blood Transfusion, Changchun Central Blood Station, Changchun 130033, ChinaInstitution of Blood Transfusion, Changchun Central Blood Station, Changchun 130033, ChinaInstitution of Blood Transfusion, Changchun Central Blood Station, Changchun 130033, ChinaObjective To provide foundational data for exploring the association between KIR genes and diseases by analyzing the frequency and polymorphism of killer-cell immunoglobulin-like receptor (KIR) genes in Han, Manchu and Korean populations in Jilin Province. Methods KIR gene typing was performed on 129 Manchu, 198 Korean and 201 Han individuals from Jilin using the polymerase chain reaction-sequence specific primers (PCR-SSP) technique. Results KIR3DL2, KIR3DL3, KIR3DP1 and KIR2DL4 were detected in all subjects. KIR2DL1, KIR2DL3, KIR2DS4, KIR3DL1 and KIR2DP1 genes had high detection frequencies, ranging from 93% to 98% across the three ethnic groups. In contrast, the detection rates of KIR2DL2, KIR2DL5, KIR3DS1, KIR2DS1, KIR2DS2, KIR2DS3 and KIR2DS5 were lower, ranging from 13% to 45%. Notably, the detection frequencies of KIR2DL5 (17.83%) and KIR2DS1 (17.83%) in the Manchu population were significantly lower than those in the Korean (42.93%, 47.47%) and Han (33.83%, 33.33%) populations in Jilin. The detection frequencies of KIR2DL5 (42.93%) and KIR2DS1 (47.47%) were significantly higher in the Korean population compared to the Han (33.83%, 33.33%) and Manchu (17.83%, 17.83%) population. The frequency of the KIRAA haplotype in the Han population was the highest among the three ethnic groups in Jilin at 61.19%, significantly higher than that in the Korean population (42.93%). Differences between the three groups were statistically significant (P<0.05), and remained significant after Bonferroni correction (Pc<0.05). Conclusion The distribution of KIR genes in the Korean, Manchu and Han population in Jilin reflects the polymorphism of KIR genes in the Chinese population and also showcases unique ethnic genetic and regional characteristics.https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2024.10.007&lang=enkiller cell immunoglobulin-like receptors（kirs）genetic polymorphismgenotypeskorean-chinesemanchu |
| spellingShingle | HAN Yu YANG Fan LIU Lingling NIE Tingting YANG Xu JIAO Lixin Distribution frequencies of KIR genes among the Korean, Manchu and Han ethnic groups in Jilin Province Zhongguo shuxue zazhi killer cell immunoglobulin-like receptors（kirs） genetic polymorphism genotypes korean-chinese manchu |
| title | Distribution frequencies of KIR genes among the Korean, Manchu and Han ethnic groups in Jilin Province |
| title_full | Distribution frequencies of KIR genes among the Korean, Manchu and Han ethnic groups in Jilin Province |
| title_fullStr | Distribution frequencies of KIR genes among the Korean, Manchu and Han ethnic groups in Jilin Province |
| title_full_unstemmed | Distribution frequencies of KIR genes among the Korean, Manchu and Han ethnic groups in Jilin Province |
| title_short | Distribution frequencies of KIR genes among the Korean, Manchu and Han ethnic groups in Jilin Province |
| title_sort | distribution frequencies of kir genes among the korean manchu and han ethnic groups in jilin province |
| topic | killer cell immunoglobulin-like receptors（kirs） genetic polymorphism genotypes korean-chinese manchu |
| url | https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2024.10.007&lang=en |
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