Initial and peak serum levels of Krebs von den Lungen-6 for predicting the prognosis of patients with COVID-19
Background/Aims Krebs von den Lungen-6 (KL-6) is associated with prognosis in patients with COVID-19. However, there is limited data on the correlation between the prognosis of COVID-19 and varying KL-6 levels at different time points. We investigated the optimal cutoff values of the initial and pea...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
The Korean Association of Internal Medicine
2025-03-01
|
| Series: | The Korean Journal of Internal Medicine |
| Subjects: | |
| Online Access: | http://kjim.org/upload/kjim-2024-161.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849736252294692864 |
|---|---|
| author | Geonui Kim Hyeonwoo Kwon Sang Hyun Ra Euijin Chang Seongman Bae Jiwon Jung Min Jae Kim Yong Pil Chong Sang-Oh Lee Sang-Ho Choi Yang Soo Kim Sung-Han Kim |
| author_facet | Geonui Kim Hyeonwoo Kwon Sang Hyun Ra Euijin Chang Seongman Bae Jiwon Jung Min Jae Kim Yong Pil Chong Sang-Oh Lee Sang-Ho Choi Yang Soo Kim Sung-Han Kim |
| author_sort | Geonui Kim |
| collection | DOAJ |
| description | Background/Aims Krebs von den Lungen-6 (KL-6) is associated with prognosis in patients with COVID-19. However, there is limited data on the correlation between the prognosis of COVID-19 and varying KL-6 levels at different time points. We investigated the optimal cutoff values of the initial and peak serum KL-6 levels to predict mortality and evaluated their correlation with mortality. Methods This retrospective cohort study collected data on serially collected serum KL-6 levels in patients hospitalized with COVID-19 between October 2020 and January 2022 at a single tertiary hospital in South Korea. The area under the receiver operating characteristic curve and Youden index were used to determine the cutoff points for the initial and peak KL-6 levels that best predicted 30-day mortality. The association between the initial and peak KL-6 values was assessed by univariate and multivariate logistic regression models. Results A total of 349 patients were included in this study. The mean initial and peak KL-6 levels were significantly higher in the non-survivor group than in the survivor group. The initial and peak KL-6 values that best predicted 30-day mortality were 491.85 U/mL and 660.05 U/mL, respectively. An initial KL-6 level greater than 491.85 U/mL and a peak KL-6 level greater than 660.05 U/mL were significantly associated with 30-day mortality. Conclusions The initial and peak levels of KL-6 were significantly associated with 30-day mortality in hospitalized patients with COVID-19. These findings suggest that serially monitoring blood KL-6 levels could be a valuable prognostic indicator for COVID-19. |
| format | Article |
| id | doaj-art-a1b1fa3b58c8424f8633a6e472a9b48d |
| institution | DOAJ |
| issn | 1226-3303 2005-6648 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | The Korean Association of Internal Medicine |
| record_format | Article |
| series | The Korean Journal of Internal Medicine |
| spelling | doaj-art-a1b1fa3b58c8424f8633a6e472a9b48d2025-08-20T03:07:20ZengThe Korean Association of Internal MedicineThe Korean Journal of Internal Medicine1226-33032005-66482025-03-0140232132910.3904/kjim.2024.161170994Initial and peak serum levels of Krebs von den Lungen-6 for predicting the prognosis of patients with COVID-19Geonui Kim0Hyeonwoo Kwon1Sang Hyun Ra2Euijin Chang3Seongman Bae4Jiwon Jung5Min Jae Kim6Yong Pil Chong7Sang-Oh Lee8Sang-Ho Choi9Yang Soo Kim10Sung-Han Kim11Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KoreaDepartment of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KoreaDepartment of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KoreaDepartment of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KoreaDepartment of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KoreaDepartment of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KoreaDepartment of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KoreaDepartment of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KoreaDepartment of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KoreaDepartment of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KoreaDepartment of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KoreaDepartment of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KoreaBackground/Aims Krebs von den Lungen-6 (KL-6) is associated with prognosis in patients with COVID-19. However, there is limited data on the correlation between the prognosis of COVID-19 and varying KL-6 levels at different time points. We investigated the optimal cutoff values of the initial and peak serum KL-6 levels to predict mortality and evaluated their correlation with mortality. Methods This retrospective cohort study collected data on serially collected serum KL-6 levels in patients hospitalized with COVID-19 between October 2020 and January 2022 at a single tertiary hospital in South Korea. The area under the receiver operating characteristic curve and Youden index were used to determine the cutoff points for the initial and peak KL-6 levels that best predicted 30-day mortality. The association between the initial and peak KL-6 values was assessed by univariate and multivariate logistic regression models. Results A total of 349 patients were included in this study. The mean initial and peak KL-6 levels were significantly higher in the non-survivor group than in the survivor group. The initial and peak KL-6 values that best predicted 30-day mortality were 491.85 U/mL and 660.05 U/mL, respectively. An initial KL-6 level greater than 491.85 U/mL and a peak KL-6 level greater than 660.05 U/mL were significantly associated with 30-day mortality. Conclusions The initial and peak levels of KL-6 were significantly associated with 30-day mortality in hospitalized patients with COVID-19. These findings suggest that serially monitoring blood KL-6 levels could be a valuable prognostic indicator for COVID-19.http://kjim.org/upload/kjim-2024-161.pdfkl-6 antigencovid-19prognosis |
| spellingShingle | Geonui Kim Hyeonwoo Kwon Sang Hyun Ra Euijin Chang Seongman Bae Jiwon Jung Min Jae Kim Yong Pil Chong Sang-Oh Lee Sang-Ho Choi Yang Soo Kim Sung-Han Kim Initial and peak serum levels of Krebs von den Lungen-6 for predicting the prognosis of patients with COVID-19 The Korean Journal of Internal Medicine kl-6 antigen covid-19 prognosis |
| title | Initial and peak serum levels of Krebs von den Lungen-6 for predicting the prognosis of patients with COVID-19 |
| title_full | Initial and peak serum levels of Krebs von den Lungen-6 for predicting the prognosis of patients with COVID-19 |
| title_fullStr | Initial and peak serum levels of Krebs von den Lungen-6 for predicting the prognosis of patients with COVID-19 |
| title_full_unstemmed | Initial and peak serum levels of Krebs von den Lungen-6 for predicting the prognosis of patients with COVID-19 |
| title_short | Initial and peak serum levels of Krebs von den Lungen-6 for predicting the prognosis of patients with COVID-19 |
| title_sort | initial and peak serum levels of krebs von den lungen 6 for predicting the prognosis of patients with covid 19 |
| topic | kl-6 antigen covid-19 prognosis |
| url | http://kjim.org/upload/kjim-2024-161.pdf |
| work_keys_str_mv | AT geonuikim initialandpeakserumlevelsofkrebsvondenlungen6forpredictingtheprognosisofpatientswithcovid19 AT hyeonwookwon initialandpeakserumlevelsofkrebsvondenlungen6forpredictingtheprognosisofpatientswithcovid19 AT sanghyunra initialandpeakserumlevelsofkrebsvondenlungen6forpredictingtheprognosisofpatientswithcovid19 AT euijinchang initialandpeakserumlevelsofkrebsvondenlungen6forpredictingtheprognosisofpatientswithcovid19 AT seongmanbae initialandpeakserumlevelsofkrebsvondenlungen6forpredictingtheprognosisofpatientswithcovid19 AT jiwonjung initialandpeakserumlevelsofkrebsvondenlungen6forpredictingtheprognosisofpatientswithcovid19 AT minjaekim initialandpeakserumlevelsofkrebsvondenlungen6forpredictingtheprognosisofpatientswithcovid19 AT yongpilchong initialandpeakserumlevelsofkrebsvondenlungen6forpredictingtheprognosisofpatientswithcovid19 AT sangohlee initialandpeakserumlevelsofkrebsvondenlungen6forpredictingtheprognosisofpatientswithcovid19 AT sanghochoi initialandpeakserumlevelsofkrebsvondenlungen6forpredictingtheprognosisofpatientswithcovid19 AT yangsookim initialandpeakserumlevelsofkrebsvondenlungen6forpredictingtheprognosisofpatientswithcovid19 AT sunghankim initialandpeakserumlevelsofkrebsvondenlungen6forpredictingtheprognosisofpatientswithcovid19 |