Synthesis, characterization and antimicrobial effect of Cu(ii) and Zn(ii) compounds derived from 1,2,4-triazoles
Compounds of Cu(II) and Zn(II) with 3-R-1H-1,2,4-triazole-5-amine {R = methyl (mta), phenyl (pta)} were prepared and characterized by infrared spectroscopy (IR), multinuclear NMR (1H, 13C), electronic spectroscopy (UV-VIS), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC),...
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Universidade Federal de Viçosa (UFV)
2022-01-01
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| Series: | The Journal of Engineering and Exact Sciences |
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| Online Access: | https://periodicos.ufv.br/jcec/article/view/13427 |
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| author | Patricia Saraiva Vilas Boas de Almeida José Roberto da Silveira Maia Mariana Caliman Falqueto Leandro Licursi de Oliveira |
| author_facet | Patricia Saraiva Vilas Boas de Almeida José Roberto da Silveira Maia Mariana Caliman Falqueto Leandro Licursi de Oliveira |
| author_sort | Patricia Saraiva Vilas Boas de Almeida |
| collection | DOAJ |
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Compounds of Cu(II) and Zn(II) with 3-R-1H-1,2,4-triazole-5-amine {R = methyl (mta), phenyl (pta)} were prepared and characterized by infrared spectroscopy (IR), multinuclear NMR (1H, 13C), electronic spectroscopy (UV-VIS), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), microanalyses and melting point. Dimeric, monomeric, and polymeric materials were synthesized in this work. The Zn(II)-1,2,4-triazole derivatives have the metal ion at the center of two geometric arrangements, being a tetrahedron for the complex-7 and 9, and an octahedron for the complex-8. The only polymeric material, complex-7, was characterized by the DSC analytical data. The Decomposition reaction of complex-8 in chloroform produced the complex-9, a aminoguanidine derivative, and the Zn(II)-benzoate compound. The IR and UV-VIS of Cu(II)-mta derivatives revealed two possible geometric patterns for the metallic ion; a distorted bipyramidal trigonal geometry for compounds 10 and 11 in solution, and in the solid state, the same geometry for complex-10, but for complex-11, the IR data suggest a distorted octahedral geometry. The biological assay of the 1,2,4-triazole compounds and their metal derivatives against Gram-positive and Gram-negative bacteria shown the compounds of Zn(II) as the only active materials with values of MIC within the range of 133.5 µM (83.3 µg / mL) to 360.7 µM (166.6 µg / mL).
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| format | Article |
| id | doaj-art-a199c993112144d8b7b3c8d038fee279 |
| institution | Kabale University |
| issn | 2527-1075 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Universidade Federal de Viçosa (UFV) |
| record_format | Article |
| series | The Journal of Engineering and Exact Sciences |
| spelling | doaj-art-a199c993112144d8b7b3c8d038fee2792025-02-02T19:56:47ZengUniversidade Federal de Viçosa (UFV)The Journal of Engineering and Exact Sciences2527-10752022-01-018110.18540/jcecvl8iss1pp13427-01-14eSynthesis, characterization and antimicrobial effect of Cu(ii) and Zn(ii) compounds derived from 1,2,4-triazolesPatricia Saraiva Vilas Boas de Almeida0José Roberto da Silveira Maia1Mariana Caliman Falqueto2Leandro Licursi de Oliveira3Universidade Federal de Viçosa - UFVUniversidade Federal de Viçosa - UFVUniversidade Federal de Viçosa - UFVUniversidade Federal de Viçosa - UFV Compounds of Cu(II) and Zn(II) with 3-R-1H-1,2,4-triazole-5-amine {R = methyl (mta), phenyl (pta)} were prepared and characterized by infrared spectroscopy (IR), multinuclear NMR (1H, 13C), electronic spectroscopy (UV-VIS), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), microanalyses and melting point. Dimeric, monomeric, and polymeric materials were synthesized in this work. The Zn(II)-1,2,4-triazole derivatives have the metal ion at the center of two geometric arrangements, being a tetrahedron for the complex-7 and 9, and an octahedron for the complex-8. The only polymeric material, complex-7, was characterized by the DSC analytical data. The Decomposition reaction of complex-8 in chloroform produced the complex-9, a aminoguanidine derivative, and the Zn(II)-benzoate compound. The IR and UV-VIS of Cu(II)-mta derivatives revealed two possible geometric patterns for the metallic ion; a distorted bipyramidal trigonal geometry for compounds 10 and 11 in solution, and in the solid state, the same geometry for complex-10, but for complex-11, the IR data suggest a distorted octahedral geometry. The biological assay of the 1,2,4-triazole compounds and their metal derivatives against Gram-positive and Gram-negative bacteria shown the compounds of Zn(II) as the only active materials with values of MIC within the range of 133.5 µM (83.3 µg / mL) to 360.7 µM (166.6 µg / mL). https://periodicos.ufv.br/jcec/article/view/13427Cu(II)Zn(II)Antimicrobial effect1 2 4-triazole compoundsTransition metals |
| spellingShingle | Patricia Saraiva Vilas Boas de Almeida José Roberto da Silveira Maia Mariana Caliman Falqueto Leandro Licursi de Oliveira Synthesis, characterization and antimicrobial effect of Cu(ii) and Zn(ii) compounds derived from 1,2,4-triazoles The Journal of Engineering and Exact Sciences Cu(II) Zn(II) Antimicrobial effect 1 2 4-triazole compounds Transition metals |
| title | Synthesis, characterization and antimicrobial effect of Cu(ii) and Zn(ii) compounds derived from 1,2,4-triazoles |
| title_full | Synthesis, characterization and antimicrobial effect of Cu(ii) and Zn(ii) compounds derived from 1,2,4-triazoles |
| title_fullStr | Synthesis, characterization and antimicrobial effect of Cu(ii) and Zn(ii) compounds derived from 1,2,4-triazoles |
| title_full_unstemmed | Synthesis, characterization and antimicrobial effect of Cu(ii) and Zn(ii) compounds derived from 1,2,4-triazoles |
| title_short | Synthesis, characterization and antimicrobial effect of Cu(ii) and Zn(ii) compounds derived from 1,2,4-triazoles |
| title_sort | synthesis characterization and antimicrobial effect of cu ii and zn ii compounds derived from 1 2 4 triazoles |
| topic | Cu(II) Zn(II) Antimicrobial effect 1 2 4-triazole compounds Transition metals |
| url | https://periodicos.ufv.br/jcec/article/view/13427 |
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