Combustion Synthesis Porous Nitinol for Biomedical Applications
Porous Nitinol with a three-dimensional anisotropic interconnective open pore structure has been successfully produced by the combustion synthesis (CS) of elemental Ni and Ti powders. The resulting product can be tailored to closely match the stiffness of cancellous bone to minimize stress shielding...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | International Journal of Biomaterials |
| Online Access: | http://dx.doi.org/10.1155/2019/4307461 |
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| _version_ | 1832551753549086720 |
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| author | H. Aihara J. Zider G. Fanton T. Duerig |
| author_facet | H. Aihara J. Zider G. Fanton T. Duerig |
| author_sort | H. Aihara |
| collection | DOAJ |
| description | Porous Nitinol with a three-dimensional anisotropic interconnective open pore structure has been successfully produced by the combustion synthesis (CS) of elemental Ni and Ti powders. The resulting product can be tailored to closely match the stiffness of cancellous bone to minimize stress shielding. The average elastic modulus was approximately 1 GPa for a porosity of 60 vol% and the average pore size of 100-500 µm. The low elastic modulus meets the basic demand for orthopedic bone ingrowth applications. Furthermore, porous Nitinol was composed of cubic (austenitic) and monoclinic (martensitic) NiTi compounds without the presence of Ni metal or Ni-rich phases. The resulting product exhibits excellent corrosion resistance with breakdown potentials above 750mV. An ovine study in cortical sites of the tibia demonstrated rapid osseointegration into the porous strucutre as early as two weeks and complete bone growth across the implant at six weeks. A separate ovine study showed complete through-growth of bone at four months using a lumbar interbody fusion model, substantiating the use of porous Nitinol as an implant material for applications in the spine. Porous Nitinol is thus a promising biomaterial with proven biocompatibility and exceptional osseointegration performance which may enhance the healing process and promote long-term fixation, making it a strong candidate for a wide range of orthopedic implant applications. |
| format | Article |
| id | doaj-art-a188abbb7a014ab592231c073c21de90 |
| institution | Kabale University |
| issn | 1687-8787 1687-8795 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Biomaterials |
| spelling | doaj-art-a188abbb7a014ab592231c073c21de902025-02-03T06:00:39ZengWileyInternational Journal of Biomaterials1687-87871687-87952019-01-01201910.1155/2019/43074614307461Combustion Synthesis Porous Nitinol for Biomedical ApplicationsH. Aihara0J. Zider1G. Fanton2T. Duerig3PorOsteon Spine Inc., Menlo Park, California, USAPorOsteon Spine Inc., Menlo Park, California, USADepartment of Orthopedic Surgery, Sports Medicine Division, Stanford University Medical Center, Palo, Alto, California, USAConfluent Medical Technologies, Fremont, California, USAPorous Nitinol with a three-dimensional anisotropic interconnective open pore structure has been successfully produced by the combustion synthesis (CS) of elemental Ni and Ti powders. The resulting product can be tailored to closely match the stiffness of cancellous bone to minimize stress shielding. The average elastic modulus was approximately 1 GPa for a porosity of 60 vol% and the average pore size of 100-500 µm. The low elastic modulus meets the basic demand for orthopedic bone ingrowth applications. Furthermore, porous Nitinol was composed of cubic (austenitic) and monoclinic (martensitic) NiTi compounds without the presence of Ni metal or Ni-rich phases. The resulting product exhibits excellent corrosion resistance with breakdown potentials above 750mV. An ovine study in cortical sites of the tibia demonstrated rapid osseointegration into the porous strucutre as early as two weeks and complete bone growth across the implant at six weeks. A separate ovine study showed complete through-growth of bone at four months using a lumbar interbody fusion model, substantiating the use of porous Nitinol as an implant material for applications in the spine. Porous Nitinol is thus a promising biomaterial with proven biocompatibility and exceptional osseointegration performance which may enhance the healing process and promote long-term fixation, making it a strong candidate for a wide range of orthopedic implant applications.http://dx.doi.org/10.1155/2019/4307461 |
| spellingShingle | H. Aihara J. Zider G. Fanton T. Duerig Combustion Synthesis Porous Nitinol for Biomedical Applications International Journal of Biomaterials |
| title | Combustion Synthesis Porous Nitinol for Biomedical Applications |
| title_full | Combustion Synthesis Porous Nitinol for Biomedical Applications |
| title_fullStr | Combustion Synthesis Porous Nitinol for Biomedical Applications |
| title_full_unstemmed | Combustion Synthesis Porous Nitinol for Biomedical Applications |
| title_short | Combustion Synthesis Porous Nitinol for Biomedical Applications |
| title_sort | combustion synthesis porous nitinol for biomedical applications |
| url | http://dx.doi.org/10.1155/2019/4307461 |
| work_keys_str_mv | AT haihara combustionsynthesisporousnitinolforbiomedicalapplications AT jzider combustionsynthesisporousnitinolforbiomedicalapplications AT gfanton combustionsynthesisporousnitinolforbiomedicalapplications AT tduerig combustionsynthesisporousnitinolforbiomedicalapplications |