Novel Indices of Glucose Homeostasis Derived from Principal Component Analysis: Application for Metabolic Assessment in Pregnancy
Aims. This study is aimed at assessing the association of previously developed indices of glucose homeostasis derived from principal component analysis (PCA) with parameters of insulin action, secretion, and beta cell function during pregnancy. Methods. In this prospective longitudinal study, an ora...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2020/4950584 |
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| author | Tina Stopp Michael Feichtinger Ingo Rosicky Gülen Yerlikaya-Schatten Johannes Ott Hans Christian Egarter Christian Schatten Wolfgang Eppel Peter Husslein Martina Mittlböck Andrea Tura Christian S. Göbl |
| author_facet | Tina Stopp Michael Feichtinger Ingo Rosicky Gülen Yerlikaya-Schatten Johannes Ott Hans Christian Egarter Christian Schatten Wolfgang Eppel Peter Husslein Martina Mittlböck Andrea Tura Christian S. Göbl |
| author_sort | Tina Stopp |
| collection | DOAJ |
| description | Aims. This study is aimed at assessing the association of previously developed indices of glucose homeostasis derived from principal component analysis (PCA) with parameters of insulin action, secretion, and beta cell function during pregnancy. Methods. In this prospective longitudinal study, an oral glucose tolerance test was performed in sixty-seven pregnant women at two prepartum (12+0 to 22+6 and 24+0 to 28+6) and one postpartum (2 to 11 months) visits. Three principal component scores (PCS) were calculated based on measurements of glucose, insulin, C-peptide, age, and BMI to assess their association with fasting and dynamic indices of insulin action, secretion, and β-cell function. Results. PCS1 was positively associated with fasting and dynamic parameters of insulin sensitivity (Matsuda index: r=0.93, p<0.001), whereas a strong negative association was observed for early, late, and total insulin response. PCS2 was associated with higher mean glucose but negatively related to parameters of insulin secretion. PCS3 was significantly associated with fasting indices of insulin sensitivity. PCS1 to 3 assessed at early pregnancy were also associated with development of GDM, whereby random forest analysis revealed the highest variable importance for PCS1. PCS1 to 3 were significantly related to the oral disposition index explaining 49.0% of its variance. Conclusions. PCS1 to 3 behaved similarly as compared to previous observations in nonpregnant women and were furthermore associated with the development of GDM. These findings support our hypothesis that PCS1 to 3 could be used as novel indices of glucose disposal during pregnancy. |
| format | Article |
| id | doaj-art-a18850a4d28b4e5db7e5c9b6efed2409 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-a18850a4d28b4e5db7e5c9b6efed24092025-02-03T06:43:41ZengWileyJournal of Diabetes Research2314-67452314-67532020-01-01202010.1155/2020/49505844950584Novel Indices of Glucose Homeostasis Derived from Principal Component Analysis: Application for Metabolic Assessment in PregnancyTina Stopp0Michael Feichtinger1Ingo Rosicky2Gülen Yerlikaya-Schatten3Johannes Ott4Hans Christian Egarter5Christian Schatten6Wolfgang Eppel7Peter Husslein8Martina Mittlböck9Andrea Tura10Christian S. Göbl11Department of Gynecology and Obstetrics, Division of Feto-Maternal Medicine, Medical University of Vienna, Vienna, AustriaDepartment of Gynecology and Obstetrics, Division of Feto-Maternal Medicine, Medical University of Vienna, Vienna, AustriaDepartment of Gynecology and Obstetrics, Division of Feto-Maternal Medicine, Medical University of Vienna, Vienna, AustriaDepartment of Gynecology and Obstetrics, Division of Feto-Maternal Medicine, Medical University of Vienna, Vienna, AustriaDepartment of Obstetrics and Gynecology, Division of Gynecologic Endocrinology and Reproductive Medicine, Medical University of Vienna, Vienna, AustriaDepartment of Obstetrics and Gynecology, Division of Gynecologic Endocrinology and Reproductive Medicine, Medical University of Vienna, Vienna, AustriaDepartment of Gynecology and Obstetrics, Division of Feto-Maternal Medicine, Medical University of Vienna, Vienna, AustriaDepartment of Gynecology and Obstetrics, Division of Feto-Maternal Medicine, Medical University of Vienna, Vienna, AustriaDepartment of Gynecology and Obstetrics, Division of Feto-Maternal Medicine, Medical University of Vienna, Vienna, AustriaCenter of Medical Statistics, Informatics, and Intelligent Systems, Section for Clinical Biometrics, Medical University of Vienna, Vienna, AustriaMetabolic Unit, CNR Institute of Neuroscience, Padova, ItalyDepartment of Gynecology and Obstetrics, Division of Feto-Maternal Medicine, Medical University of Vienna, Vienna, AustriaAims. This study is aimed at assessing the association of previously developed indices of glucose homeostasis derived from principal component analysis (PCA) with parameters of insulin action, secretion, and beta cell function during pregnancy. Methods. In this prospective longitudinal study, an oral glucose tolerance test was performed in sixty-seven pregnant women at two prepartum (12+0 to 22+6 and 24+0 to 28+6) and one postpartum (2 to 11 months) visits. Three principal component scores (PCS) were calculated based on measurements of glucose, insulin, C-peptide, age, and BMI to assess their association with fasting and dynamic indices of insulin action, secretion, and β-cell function. Results. PCS1 was positively associated with fasting and dynamic parameters of insulin sensitivity (Matsuda index: r=0.93, p<0.001), whereas a strong negative association was observed for early, late, and total insulin response. PCS2 was associated with higher mean glucose but negatively related to parameters of insulin secretion. PCS3 was significantly associated with fasting indices of insulin sensitivity. PCS1 to 3 assessed at early pregnancy were also associated with development of GDM, whereby random forest analysis revealed the highest variable importance for PCS1. PCS1 to 3 were significantly related to the oral disposition index explaining 49.0% of its variance. Conclusions. PCS1 to 3 behaved similarly as compared to previous observations in nonpregnant women and were furthermore associated with the development of GDM. These findings support our hypothesis that PCS1 to 3 could be used as novel indices of glucose disposal during pregnancy.http://dx.doi.org/10.1155/2020/4950584 |
| spellingShingle | Tina Stopp Michael Feichtinger Ingo Rosicky Gülen Yerlikaya-Schatten Johannes Ott Hans Christian Egarter Christian Schatten Wolfgang Eppel Peter Husslein Martina Mittlböck Andrea Tura Christian S. Göbl Novel Indices of Glucose Homeostasis Derived from Principal Component Analysis: Application for Metabolic Assessment in Pregnancy Journal of Diabetes Research |
| title | Novel Indices of Glucose Homeostasis Derived from Principal Component Analysis: Application for Metabolic Assessment in Pregnancy |
| title_full | Novel Indices of Glucose Homeostasis Derived from Principal Component Analysis: Application for Metabolic Assessment in Pregnancy |
| title_fullStr | Novel Indices of Glucose Homeostasis Derived from Principal Component Analysis: Application for Metabolic Assessment in Pregnancy |
| title_full_unstemmed | Novel Indices of Glucose Homeostasis Derived from Principal Component Analysis: Application for Metabolic Assessment in Pregnancy |
| title_short | Novel Indices of Glucose Homeostasis Derived from Principal Component Analysis: Application for Metabolic Assessment in Pregnancy |
| title_sort | novel indices of glucose homeostasis derived from principal component analysis application for metabolic assessment in pregnancy |
| url | http://dx.doi.org/10.1155/2020/4950584 |
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