Novel treatment strategy targeting interleukin-6 induced by cancer associated fibroblasts for peritoneal metastasis of gastric cancer

Novel treatment strategy targeting interleukin-6 induced by cancer associated fibroblasts for peritoneal metastasis of gastric cancer

Abstract Cancer-associated fibroblasts (CAFs) are a crucial component in the tumor microenvironment (TME) of peritoneal metastasis (PM), where they contribute to tumor progression and metastasis via secretion of interleukin-6 (IL-6). Here, we investigated the role of IL-6 in PM of gastric cancer (GC...

Full description

Saved in:

Bibliographic Details
Main Authors:	Ema Mitsui, Satoru Kikuchi, Tomohiro Okura, Hiroshi Tazawa, Yuta Une, Noriyuki Nishiwaki, Shinji Kuroda, Kazuhiro Noma, Shunsuke Kagawa, Toshiaki Ohara, Junko Ohtsuka, Rieko Ohki, Toshiyoshi Fujiwara
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-01-01
Series:	Scientific Reports
Subjects:	Peritoneal metastasis Gastric cancer Interleukin-6 Cancer-associated fibroblasts Interleukin-6 receptor antibody
Online Access:	https://doi.org/10.1038/s41598-025-88033-0
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

The role of interleukin-6 classic and trans-signaling and interleukin-11 classic signaling in gastric cancer cells
by: Josephine Runge, et al.
Published: (2024-08-01)

Serum interleukin-6, interleukin-8, and interleukin-1 receptor antagonist levels in South Indian fibromyalgia patients and its correlation with disease severity
by: Sandeep Surendran, et al.
Published: (2021-01-01)

Nano-curcumin Effects on Ischemic Stroke clinical outcomes and Interleukin-6 Levels: Pilot Randomized Clinical Trial
by: Zeinab Ehtiatkar, et al.
Published: (2025-01-01)

Evaluation of Inflammatory Cytokine Secretion by Human Alveolar Macrophages
by: J. E. Losa García, et al.
Published: (1999-01-01)

The role of the cytokines IL-27 and IL-35 in cancer
by: Avner Friedman, et al.
Published: (2015-07-01)

Evaluating the role of inflammatory biomarkers as a diagnostic tool in peri-implantitis
by: Ayan Saxena, et al.
Published: (2025-03-01)

Analysis of the effects of group progressive resistance training on inflammatory markers, cardiovascular fitness parameters, and respiratory function in elderly patients with chronic obstructive pulmonary disease
by: Chunyang Li, et al.
Published: (2025-01-01)

Role of interleukin-15 and interleukin-18 in the secretion of sIL-6R and sgp130 by human neutrophils
by: E. Jablonska, et al.
Published: (2003-01-01)

The Impact of Amniotic Fluid Interleukin-6, Interleukin-8, and Metalloproteinase-9 on Preterm Labor: A Narrative Review
by: Theodoros Karampitsakos, et al.
Published: (2025-01-01)

Il-6 signaling exacerbates hallmarks of chronic tendon disease by stimulating reparative fibroblasts
by: Tino Stauber, et al.
Published: (2025-02-01)

Impact of diabetes mellitus on dental implants: A cross sectional controlled clinical study.
by: Rezhna Muhammed Hamad-Ameen, et al.
Published: (2023-12-01)

IL-6–174 G/C transversion might decrease male infertility risk: A case-control study
by: Tayyebeh Zamani-Badi, et al.
Published: (2025-02-01)

Serum choline, leptin and interleukin-6 levels in fibromyalgia syndrome-induced pain: a case–control study
by: Elif Baris, et al.
Published: (2025-02-01)

Immunoinflammatory Response to Acute Noise Stress in Male Rats Adapted with Different Exercise Training
by: Elaheh Farahbakht, et al.
Published: (2023-12-01)

IL-6 and PD-1 antibody blockade combination therapy regulate inflammation and T lymphocyte apoptosis in murine model of sepsis
by: Song I Lee, et al.
Published: (2025-01-01)

Age-dependent differences in the association between blood interleukin-6 levels and mortality in patients with sepsis: a retrospective observational study
by: Takashi Shimazui, et al.
Published: (2025-01-01)

The relationship of the carriership of allelic variations in rs2228145 (A > C) of the<i>IL6R</i> gene with the levels of <i>VCAM1</i> and <i>ICAM1</i> gene transcripts in patients with essential hypertension
by: L. V. Topchieva, et al.
Published: (2020-03-01)

Biomarkers of inflammation and colorectal cancer risk
by: Yuting Li, et al.
Published: (2025-02-01)

Candidate approaches for predicting vitiligo recurrence: an effective model and biomarkers
by: Binhao Liu, et al.
Published: (2025-02-01)

Sarilumab is not Inferior to Tocilizumab in the Treatment of Cytokine Release Syndrome in COVID-19
by: V. T. Ivashkin, et al.
Published: (2023-12-01)

Infective Complications of Endobronchial Ultrasound-Transbronchial Needle Aspiration (EBUS-TBNA) and Clinical Biomarkers: A Concise Review
by: Pinelopi Bosgana, et al.
Published: (2025-01-01)

Analysis of tumor-infiltrating exhausted T cells highlights IL-6 and PD1 blockade as a combined immunotherapy strategy for non-small cell lung cancer
by: Lulu Zhang, et al.
Published: (2025-02-01)

The role of interleukin-17 in inflammation-related cancers
by: Xingru Zhang, et al.
Published: (2025-01-01)

Intraoperative dynamics of interleukin-6 levels during planned coronary stenting with different approaches to analgesic sedation
by: D.О. Dziuba
Published: (2020-10-01)

Interleukin-6 related signaling pathways as the intersection between chronic diseases and sepsis
by: Jie Yang, et al.
Published: (2025-01-01)

Chronic kidney disease and inflammatory cytokines in rheumatoid arthritis: a potential pathogenic link
by: Hironari Hanaoka, et al.
Published: (2025-01-01)

Circulating endothelial progenitor cells and inflammatory markers in type 1 diabetes after an acute session of aerobic exercise
by: Patrícia Martins Bock, et al.
Published: (2025-01-01)

IL-6-Inducing Peptide Prediction Based on 3D Structure and Graph Neural Network
by: Ruifen Cao, et al.
Published: (2025-01-01)

Inhibition of hippocampal interleukin-6 receptor-evoked signalling normalises long-term potentiation in dystrophin-deficient mdx mice
by: Kimberley A. Stephenson, et al.
Published: (2025-02-01)

Assessment of IL-6 Pathway Inhibition in Gastrointestinal Behçet’s Disease from Immunological and Clinical Perspectives
by: Makoto Naganuma, et al.
Published: (2025-01-01)

Genome-wide association study analysis of single nucleotide variants in L. infantum associated with IL-6 inflammatory response in visceral leishmaniasis
by: Amanda Miranda da Silva, et al.

Current concepts in the pathogenesis of spondyloarthritis
by: Nibha Jain, et al.
Published: (2020-01-01)

Interleukin‐37 promotes DMBA/TPA skin cancer through SIGIRR‐mediated inhibition of glycolysis in CD103+DC cells
by: Fan‐lian Zeng, et al.
Published: (2023-04-01)

Serum levels of interleukin-6 type cytokines and soluble interleukin-6 receptor in patients with rheumatoid arthritis
by: T. Robak, et al.
Published: (1998-01-01)

Characterisation of IGF-1 (rs7136446) and IL-6 (rs1800795) polymorphisms among breast cancer patients in western Algeria
by: Fatima Zohraa Boussouf, et al.
Published: (2024-10-01)

The role of the interleukin family in liver fibrosis
by: Zixin Zhang, et al.
Published: (2025-02-01)

B cells enhance IL-1 beta driven invasiveness in triple negative breast cancer
by: Nicole J. Toney, et al.
Published: (2025-01-01)

Interleukin-12 Inhibits Tumor Growth and Metastasis Promoted by Tumor-Associated Mesenchymal Stem Cells in Triple-Negative Breast Cancer
by: Babak Jahangiri, et al.
Published: (2024-09-01)

CAV1 promotes epithelial-to-mesenchymal transition (EMT) and chronic renal allograft interstitial fibrosis by activating the ferroptosis pathway
by: Qianguang Han, et al.
Published: (2025-02-01)

No effects of ozonated autohemotherapy on inflammation response in hemodialyzed patients
by: Leszek Tylicki, et al.
Published: (2004-01-01)