Case report: Significant lesion reduction and neural structural changes following ibogaine treatments for multiple sclerosis
Multiple sclerosis (MS) is a debilitating neurodegenerative disease characterized by demyelination and neuronal loss. Traditional therapies often fail to halt disease progression or reverse neurological deficits. Ibogaine, a psychoactive alkaloid, has been proposed as a potential neuroregenerative a...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1535782/full |
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| author | David Qixiang Chen José Adalberto Inzunza Domínguez Juan Manuel Valle Uzeta Abhiram P. Pushparaj Abhiram P. Pushparaj Jonathan E. Dickinson |
| author_facet | David Qixiang Chen José Adalberto Inzunza Domínguez Juan Manuel Valle Uzeta Abhiram P. Pushparaj Abhiram P. Pushparaj Jonathan E. Dickinson |
| author_sort | David Qixiang Chen |
| collection | DOAJ |
| description | Multiple sclerosis (MS) is a debilitating neurodegenerative disease characterized by demyelination and neuronal loss. Traditional therapies often fail to halt disease progression or reverse neurological deficits. Ibogaine, a psychoactive alkaloid, has been proposed as a potential neuroregenerative agent due to its multifaceted pharmacological profile. We present two case studies of MS patients who underwent a novel ibogaine treatment, highlighting significant neuroimaging changes and clinical improvements. Patient A demonstrated substantial lesion shrinkage and decreased Apparent Diffusion Coefficient (ADC) values, suggesting remyelination and reduced inflammation. Both patients exhibited cortical and subcortical alterations, particularly in regions associated with pain and emotional processing. These findings suggest that ibogaine may promote neuroplasticity and modulate neurocircuitry involved in MS pathology. |
| format | Article |
| id | doaj-art-a176954abdb34b7291516c7ecb4865c4 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-a176954abdb34b7291516c7ecb4865c42025-02-06T05:21:46ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-02-011610.3389/fimmu.2025.15357821535782Case report: Significant lesion reduction and neural structural changes following ibogaine treatments for multiple sclerosisDavid Qixiang Chen0José Adalberto Inzunza Domínguez1Juan Manuel Valle Uzeta2Abhiram P. Pushparaj3Abhiram P. Pushparaj4Jonathan E. Dickinson5Ambio Life Sciences, Vancouver, BC, CanadaAmbio Life Sciences, Vancouver, BC, CanadaMedical Department, Ambio Life Sciences, Vancouver, BC, CanadaAmbio Life Sciences, Vancouver, BC, CanadaConsulting Department, +ROI Regulatory Advisory, Toronto, ON, CanadaAmbio Life Sciences, Vancouver, BC, CanadaMultiple sclerosis (MS) is a debilitating neurodegenerative disease characterized by demyelination and neuronal loss. Traditional therapies often fail to halt disease progression or reverse neurological deficits. Ibogaine, a psychoactive alkaloid, has been proposed as a potential neuroregenerative agent due to its multifaceted pharmacological profile. We present two case studies of MS patients who underwent a novel ibogaine treatment, highlighting significant neuroimaging changes and clinical improvements. Patient A demonstrated substantial lesion shrinkage and decreased Apparent Diffusion Coefficient (ADC) values, suggesting remyelination and reduced inflammation. Both patients exhibited cortical and subcortical alterations, particularly in regions associated with pain and emotional processing. These findings suggest that ibogaine may promote neuroplasticity and modulate neurocircuitry involved in MS pathology.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1535782/fullibogainenoribogainemultiple sclerosispsychedelic medicineneuroregenerationneuroimaging |
| spellingShingle | David Qixiang Chen José Adalberto Inzunza Domínguez Juan Manuel Valle Uzeta Abhiram P. Pushparaj Abhiram P. Pushparaj Jonathan E. Dickinson Case report: Significant lesion reduction and neural structural changes following ibogaine treatments for multiple sclerosis Frontiers in Immunology ibogaine noribogaine multiple sclerosis psychedelic medicine neuroregeneration neuroimaging |
| title | Case report: Significant lesion reduction and neural structural changes following ibogaine treatments for multiple sclerosis |
| title_full | Case report: Significant lesion reduction and neural structural changes following ibogaine treatments for multiple sclerosis |
| title_fullStr | Case report: Significant lesion reduction and neural structural changes following ibogaine treatments for multiple sclerosis |
| title_full_unstemmed | Case report: Significant lesion reduction and neural structural changes following ibogaine treatments for multiple sclerosis |
| title_short | Case report: Significant lesion reduction and neural structural changes following ibogaine treatments for multiple sclerosis |
| title_sort | case report significant lesion reduction and neural structural changes following ibogaine treatments for multiple sclerosis |
| topic | ibogaine noribogaine multiple sclerosis psychedelic medicine neuroregeneration neuroimaging |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1535782/full |
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