Production of Sterilizing Agents from Calendula officinalis Extracts Optimized by Response Surface Methodology
The aim of this study was to produce hand sterilizing liquid and wet wipes with the extracts of Calendula officinalis. Since this plant has well known antimicrobial activity due to its phytochemical constituents, the increase in the extraction yield was chosen as the principle part of the production...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | International Journal of Analytical Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2015/789732 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832559020342247424 |
|---|---|
| author | Fatih Mehmet Goktas Bilgesu Sahin Sibel Yigitarslan |
| author_facet | Fatih Mehmet Goktas Bilgesu Sahin Sibel Yigitarslan |
| author_sort | Fatih Mehmet Goktas |
| collection | DOAJ |
| description | The aim of this study was to produce hand sterilizing liquid and wet wipes with the extracts of Calendula officinalis. Since this plant has well known antimicrobial activity due to its phytochemical constituents, the increase in the extraction yield was chosen as the principle part of the production process. To achieve the maximum yield, parameters of solid-to-liquid ratio, extraction temperature, and time were studied. The optimum conditions were determined by response surface methodology as 41°C, 7 h, and 3.3 g/200 mL for temperature, time, and solid-to-liquid ratio, respectively. The yield achieved at those conditions was found to be 90 percent. The highest amounts of flavonoids were detected at optimum, whereas the highest triterpene and saponin constituents were determined at different design points. The microbial efficiencies of extracts were determined by the inhibition of the growth of selected microorganisms. Different dilution rates and interaction times were used as parameters of inhibition. Not any of the constituent but symbiotic relation in-between reached the highest inhibition of 90 percent. The pH values of the extracts were 5.1 to 5.4. As a result, the extraction of Calendula officinalis at the optimum conditions can be used effectively in the production of wet wipes and hand sterilizing liquid. |
| format | Article |
| id | doaj-art-a16fdc443f024f1284c4cc37ac6a4304 |
| institution | Kabale University |
| issn | 1687-8760 1687-8779 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Analytical Chemistry |
| spelling | doaj-art-a16fdc443f024f1284c4cc37ac6a43042025-02-03T01:31:08ZengWileyInternational Journal of Analytical Chemistry1687-87601687-87792015-01-01201510.1155/2015/789732789732Production of Sterilizing Agents from Calendula officinalis Extracts Optimized by Response Surface MethodologyFatih Mehmet Goktas0Bilgesu Sahin1Sibel Yigitarslan2Chemical Engineering Department, Engineering Faculty, Suleyman Demirel University, West Campus, 32000 Isparta, TurkeyChemical Engineering Department, Engineering Faculty, Suleyman Demirel University, West Campus, 32000 Isparta, TurkeyChemical Engineering Department, Engineering Faculty, Suleyman Demirel University, West Campus, 32000 Isparta, TurkeyThe aim of this study was to produce hand sterilizing liquid and wet wipes with the extracts of Calendula officinalis. Since this plant has well known antimicrobial activity due to its phytochemical constituents, the increase in the extraction yield was chosen as the principle part of the production process. To achieve the maximum yield, parameters of solid-to-liquid ratio, extraction temperature, and time were studied. The optimum conditions were determined by response surface methodology as 41°C, 7 h, and 3.3 g/200 mL for temperature, time, and solid-to-liquid ratio, respectively. The yield achieved at those conditions was found to be 90 percent. The highest amounts of flavonoids were detected at optimum, whereas the highest triterpene and saponin constituents were determined at different design points. The microbial efficiencies of extracts were determined by the inhibition of the growth of selected microorganisms. Different dilution rates and interaction times were used as parameters of inhibition. Not any of the constituent but symbiotic relation in-between reached the highest inhibition of 90 percent. The pH values of the extracts were 5.1 to 5.4. As a result, the extraction of Calendula officinalis at the optimum conditions can be used effectively in the production of wet wipes and hand sterilizing liquid.http://dx.doi.org/10.1155/2015/789732 |
| spellingShingle | Fatih Mehmet Goktas Bilgesu Sahin Sibel Yigitarslan Production of Sterilizing Agents from Calendula officinalis Extracts Optimized by Response Surface Methodology International Journal of Analytical Chemistry |
| title | Production of Sterilizing Agents from Calendula officinalis Extracts Optimized by Response Surface Methodology |
| title_full | Production of Sterilizing Agents from Calendula officinalis Extracts Optimized by Response Surface Methodology |
| title_fullStr | Production of Sterilizing Agents from Calendula officinalis Extracts Optimized by Response Surface Methodology |
| title_full_unstemmed | Production of Sterilizing Agents from Calendula officinalis Extracts Optimized by Response Surface Methodology |
| title_short | Production of Sterilizing Agents from Calendula officinalis Extracts Optimized by Response Surface Methodology |
| title_sort | production of sterilizing agents from calendula officinalis extracts optimized by response surface methodology |
| url | http://dx.doi.org/10.1155/2015/789732 |
| work_keys_str_mv | AT fatihmehmetgoktas productionofsterilizingagentsfromcalendulaofficinalisextractsoptimizedbyresponsesurfacemethodology AT bilgesusahin productionofsterilizingagentsfromcalendulaofficinalisextractsoptimizedbyresponsesurfacemethodology AT sibelyigitarslan productionofsterilizingagentsfromcalendulaofficinalisextractsoptimizedbyresponsesurfacemethodology |