Association of serum magnesium and calcium with metabolic syndrome: a cross-sectional study from the Qatar-biobank
Abstract Background and objectives Metabolic syndrome (MetS) and its constituent comorbidities, along with mineral imbalances, pose a significant health burden in the Qatari population. Although Magnesium (Mg) and Calcium (Ca) have been individually linked to MetS, the impact of the calcium-to-magne...
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BMC
2025-01-01
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| Series: | Nutrition & Metabolism |
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| Online Access: | https://doi.org/10.1186/s12986-024-00892-y |
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| author | Raneem Alsheikh Haneen Aldulaimi Rami Hinawi Fatima Al-Sadi Alanoud Al-Baker Aldana Alkuwari Muhammad Sameer Ghalya Al-Abdulla Zumin Shi Giridhara Rathnaiah Babu |
| author_facet | Raneem Alsheikh Haneen Aldulaimi Rami Hinawi Fatima Al-Sadi Alanoud Al-Baker Aldana Alkuwari Muhammad Sameer Ghalya Al-Abdulla Zumin Shi Giridhara Rathnaiah Babu |
| author_sort | Raneem Alsheikh |
| collection | DOAJ |
| description | Abstract Background and objectives Metabolic syndrome (MetS) and its constituent comorbidities, along with mineral imbalances, pose a significant health burden in the Qatari population. Although Magnesium (Mg) and Calcium (Ca) have been individually linked to MetS, the impact of the calcium-to-magnesium ratio (Ca: Mg) on MetS remains unclear, especially in the adult population of Qatar. In this study, we aim to investigate the association between the total serum concentrations of Ca, Mg and Ca: Mg ratio with the outcome of MetS. Methods This comprehensive cross-sectional study included data on 9693 participants collected by Qatar Biobank (QBB). The serum levels of Mg and Ca, in addition to recorded metabolic parameters for the study participants, were used in the analyses. The presence of MetS was deemed as our primary outcome and its components as secondary outcomes. Logistic regression models were run to examine these associations. Results and conclusion MetS was present in more than 19% of the population. The mean serum Mg was higher in the non-MetS group 0.83 ± 0.06 mmol/L compared to the MetS group 0.81 ± 0.08 mmol/L. Conversely, the mean serum Ca and Ca: Mg ratio were higher in the MetS group (2.33 ± 0.09 mmol/L, 2.92 ± 0.36 mmol/L) compared to the non-MetS group (2.30 ± 0.08 mmol/L, 2.77 ± 0.23 mmol/L) respectively. In the context of MetS, we observed a negative dose-response relationship between Mg quartiles and MetS. In contrast, we found a positive association between Ca as well as Ca: Mg ratio and MetS. |
| format | Article |
| id | doaj-art-a16938d5e4c6433f9926d69e2199ed36 |
| institution | Kabale University |
| issn | 1743-7075 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Nutrition & Metabolism |
| spelling | doaj-art-a16938d5e4c6433f9926d69e2199ed362025-02-02T12:11:45ZengBMCNutrition & Metabolism1743-70752025-01-0122111010.1186/s12986-024-00892-yAssociation of serum magnesium and calcium with metabolic syndrome: a cross-sectional study from the Qatar-biobankRaneem Alsheikh0Haneen Aldulaimi1Rami Hinawi2Fatima Al-Sadi3Alanoud Al-Baker4Aldana Alkuwari5Muhammad Sameer6Ghalya Al-Abdulla7Zumin Shi8Giridhara Rathnaiah Babu9College of Medicine, QU Health, Qatar UniversityCollege of Medicine, QU Health, Qatar UniversityCollege of Medicine, QU Health, Qatar UniversityCollege of Medicine, QU Health, Qatar UniversityCollege of Medicine, QU Health, Qatar UniversityCollege of Medicine, QU Health, Qatar UniversityCollege of Medicine, QU Health, Qatar UniversityCollege of Medicine, QU Health, Qatar UniversityHuman Nutrition Department, College of Health Sciences, QU Health, Qatar UniversityDepartment of Population Medicine, College of Medicine, QU Health, Qatar UniversityAbstract Background and objectives Metabolic syndrome (MetS) and its constituent comorbidities, along with mineral imbalances, pose a significant health burden in the Qatari population. Although Magnesium (Mg) and Calcium (Ca) have been individually linked to MetS, the impact of the calcium-to-magnesium ratio (Ca: Mg) on MetS remains unclear, especially in the adult population of Qatar. In this study, we aim to investigate the association between the total serum concentrations of Ca, Mg and Ca: Mg ratio with the outcome of MetS. Methods This comprehensive cross-sectional study included data on 9693 participants collected by Qatar Biobank (QBB). The serum levels of Mg and Ca, in addition to recorded metabolic parameters for the study participants, were used in the analyses. The presence of MetS was deemed as our primary outcome and its components as secondary outcomes. Logistic regression models were run to examine these associations. Results and conclusion MetS was present in more than 19% of the population. The mean serum Mg was higher in the non-MetS group 0.83 ± 0.06 mmol/L compared to the MetS group 0.81 ± 0.08 mmol/L. Conversely, the mean serum Ca and Ca: Mg ratio were higher in the MetS group (2.33 ± 0.09 mmol/L, 2.92 ± 0.36 mmol/L) compared to the non-MetS group (2.30 ± 0.08 mmol/L, 2.77 ± 0.23 mmol/L) respectively. In the context of MetS, we observed a negative dose-response relationship between Mg quartiles and MetS. In contrast, we found a positive association between Ca as well as Ca: Mg ratio and MetS.https://doi.org/10.1186/s12986-024-00892-yMetabolic syndrome (MetS)Serum magnesium (Mg)Serum calcium (Ca)Calcium-to-magnesium ratioQatar biobank (QBB) |
| spellingShingle | Raneem Alsheikh Haneen Aldulaimi Rami Hinawi Fatima Al-Sadi Alanoud Al-Baker Aldana Alkuwari Muhammad Sameer Ghalya Al-Abdulla Zumin Shi Giridhara Rathnaiah Babu Association of serum magnesium and calcium with metabolic syndrome: a cross-sectional study from the Qatar-biobank Nutrition & Metabolism Metabolic syndrome (MetS) Serum magnesium (Mg) Serum calcium (Ca) Calcium-to-magnesium ratio Qatar biobank (QBB) |
| title | Association of serum magnesium and calcium with metabolic syndrome: a cross-sectional study from the Qatar-biobank |
| title_full | Association of serum magnesium and calcium with metabolic syndrome: a cross-sectional study from the Qatar-biobank |
| title_fullStr | Association of serum magnesium and calcium with metabolic syndrome: a cross-sectional study from the Qatar-biobank |
| title_full_unstemmed | Association of serum magnesium and calcium with metabolic syndrome: a cross-sectional study from the Qatar-biobank |
| title_short | Association of serum magnesium and calcium with metabolic syndrome: a cross-sectional study from the Qatar-biobank |
| title_sort | association of serum magnesium and calcium with metabolic syndrome a cross sectional study from the qatar biobank |
| topic | Metabolic syndrome (MetS) Serum magnesium (Mg) Serum calcium (Ca) Calcium-to-magnesium ratio Qatar biobank (QBB) |
| url | https://doi.org/10.1186/s12986-024-00892-y |
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