GLP-1 and SGLT2 Therapies in Type 2 Diabetes Mellitus. Cutting-Edge Approaches to Advancing Diabetes Care
Type 2 diabetes mellitus (T2DM) is a multifactorial disease characterized by insulin resistance, beta-cell dysfunction, and chronic hyperglycemia. Despite the availability of conventional therapies, significant unmet needs persist in achieving optimal glycemic control and reducing long-term complic...
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| Format: | Article |
| Language: | English |
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Kazimierz Wielki University
2025-02-01
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| Series: | Journal of Education, Health and Sport |
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| Online Access: | https://apcz.umk.pl/JEHS/article/view/57478 |
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| author | Agnieszka Parfianowicz Alicja Surma |
| author_facet | Agnieszka Parfianowicz Alicja Surma |
| author_sort | Agnieszka Parfianowicz |
| collection | DOAJ |
| description |
Type 2 diabetes mellitus (T2DM) is a multifactorial disease characterized by insulin resistance, beta-cell dysfunction, and chronic hyperglycemia. Despite the availability of conventional therapies, significant unmet needs persist in achieving optimal glycemic control and reducing long-term complications. GLP-1 receptor agonists (GLP-1 RAs) and SGLT2 inhibitors represent two novel classes of antidiabetic agents that have transformed the therapeutic landscape. This paper explores their mechanisms of action, clinical benefits, and potential synergistic effects, emphasizing their impact on cardiovascular and renal outcomes. Challenges and future directions for these agents in personalized diabetes care are also discussed.
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| format | Article |
| id | doaj-art-a1691909a024430985d36e66ffcebee8 |
| institution | Kabale University |
| issn | 2391-8306 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj-art-a1691909a024430985d36e66ffcebee82025-02-06T08:18:21ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062025-02-017810.12775/JEHS.2025.78.57478GLP-1 and SGLT2 Therapies in Type 2 Diabetes Mellitus. Cutting-Edge Approaches to Advancing Diabetes CareAgnieszka Parfianowicz0https://orcid.org/0009-0009-8415-6478Alicja Surma1https://orcid.org/0009-0009-3921-478XDistrict Hospital in SochaczewProvincial Hospital in Sochaczew Type 2 diabetes mellitus (T2DM) is a multifactorial disease characterized by insulin resistance, beta-cell dysfunction, and chronic hyperglycemia. Despite the availability of conventional therapies, significant unmet needs persist in achieving optimal glycemic control and reducing long-term complications. GLP-1 receptor agonists (GLP-1 RAs) and SGLT2 inhibitors represent two novel classes of antidiabetic agents that have transformed the therapeutic landscape. This paper explores their mechanisms of action, clinical benefits, and potential synergistic effects, emphasizing their impact on cardiovascular and renal outcomes. Challenges and future directions for these agents in personalized diabetes care are also discussed. https://apcz.umk.pl/JEHS/article/view/57478type 2 diabetesflozynsdm 2 |
| spellingShingle | Agnieszka Parfianowicz Alicja Surma GLP-1 and SGLT2 Therapies in Type 2 Diabetes Mellitus. Cutting-Edge Approaches to Advancing Diabetes Care Journal of Education, Health and Sport type 2 diabetes flozyns dm 2 |
| title | GLP-1 and SGLT2 Therapies in Type 2 Diabetes Mellitus. Cutting-Edge Approaches to Advancing Diabetes Care |
| title_full | GLP-1 and SGLT2 Therapies in Type 2 Diabetes Mellitus. Cutting-Edge Approaches to Advancing Diabetes Care |
| title_fullStr | GLP-1 and SGLT2 Therapies in Type 2 Diabetes Mellitus. Cutting-Edge Approaches to Advancing Diabetes Care |
| title_full_unstemmed | GLP-1 and SGLT2 Therapies in Type 2 Diabetes Mellitus. Cutting-Edge Approaches to Advancing Diabetes Care |
| title_short | GLP-1 and SGLT2 Therapies in Type 2 Diabetes Mellitus. Cutting-Edge Approaches to Advancing Diabetes Care |
| title_sort | glp 1 and sglt2 therapies in type 2 diabetes mellitus cutting edge approaches to advancing diabetes care |
| topic | type 2 diabetes flozyns dm 2 |
| url | https://apcz.umk.pl/JEHS/article/view/57478 |
| work_keys_str_mv | AT agnieszkaparfianowicz glp1andsglt2therapiesintype2diabetesmellituscuttingedgeapproachestoadvancingdiabetescare AT alicjasurma glp1andsglt2therapiesintype2diabetesmellituscuttingedgeapproachestoadvancingdiabetescare |