Advanced Piezoelectric Materials, Devices, and Systems for Orthopedic Medicine
Abstract Harnessing the robust electromechanical couplings, piezoelectric materials not only enable efficient bio‐energy harvesting, physiological sensing and actuating but also open enormous opportunities for therapeutic treatments through surface polarization directly interacting with electroactiv...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202410400 |
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| author | Jingkai Zhang Chang Liu Jun Li Tao Yu Jing Ruan Fan Yang |
| author_facet | Jingkai Zhang Chang Liu Jun Li Tao Yu Jing Ruan Fan Yang |
| author_sort | Jingkai Zhang |
| collection | DOAJ |
| description | Abstract Harnessing the robust electromechanical couplings, piezoelectric materials not only enable efficient bio‐energy harvesting, physiological sensing and actuating but also open enormous opportunities for therapeutic treatments through surface polarization directly interacting with electroactive cells, tissues, and organs. Known for its highly oriented and hierarchical structure, collagen in natural bones produces local electrical signals to stimulate osteoblasts and promote bone formation, inspiring the application of piezoelectric materials in orthopedic medicine. Recent studies showed that piezoelectricity can impact microenvironments by regulating molecular sensors including ion channels, cytoskeletal elements, cell adhesion proteins, and other signaling pathways. This review thus focuses on discussing the pioneering applications of piezoelectricity in the diagnosis and treatment of orthopedic diseases, aiming to offer valuable insights for advancing next‐generation medical technologies. Beginning with an introduction to the principles of piezoelectricity and various piezoelectric materials, this review paper delves into the mechanisms through which piezoelectric materials accelerated osteogenesis. A comprehensive overview of piezoelectric materials, devices, and systems enhancing bone tissue repair, alleviating inflammation at infection sites, and monitoring bone health is then provided, respectively. Finally, the major challenges faced by applications of piezoelectricity in orthopedic conditions are thoroughly discussed, along with a critical outlook on future development trends. |
| format | Article |
| id | doaj-art-a1601f5f6fd44912868bf6e5d672fda6 |
| institution | Kabale University |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-a1601f5f6fd44912868bf6e5d672fda62025-01-20T13:04:18ZengWileyAdvanced Science2198-38442025-01-01123n/an/a10.1002/advs.202410400Advanced Piezoelectric Materials, Devices, and Systems for Orthopedic MedicineJingkai Zhang0Chang Liu1Jun Li2Tao Yu3Jing Ruan4Fan Yang5Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200025 ChinaDepartment of Ophthalmology Shanghai Ninth People's Hospital Shanghai JiaoTong University School of Medicine Shanghai 200011 ChinaDepartment of Materials Science and Engineering University of Wisconsin–Madison Madison WI 53706 USADepartment of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200025 ChinaDepartment of Ophthalmology Shanghai Ninth People's Hospital Shanghai JiaoTong University School of Medicine Shanghai 200011 ChinaDepartment of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200025 ChinaAbstract Harnessing the robust electromechanical couplings, piezoelectric materials not only enable efficient bio‐energy harvesting, physiological sensing and actuating but also open enormous opportunities for therapeutic treatments through surface polarization directly interacting with electroactive cells, tissues, and organs. Known for its highly oriented and hierarchical structure, collagen in natural bones produces local electrical signals to stimulate osteoblasts and promote bone formation, inspiring the application of piezoelectric materials in orthopedic medicine. Recent studies showed that piezoelectricity can impact microenvironments by regulating molecular sensors including ion channels, cytoskeletal elements, cell adhesion proteins, and other signaling pathways. This review thus focuses on discussing the pioneering applications of piezoelectricity in the diagnosis and treatment of orthopedic diseases, aiming to offer valuable insights for advancing next‐generation medical technologies. Beginning with an introduction to the principles of piezoelectricity and various piezoelectric materials, this review paper delves into the mechanisms through which piezoelectric materials accelerated osteogenesis. A comprehensive overview of piezoelectric materials, devices, and systems enhancing bone tissue repair, alleviating inflammation at infection sites, and monitoring bone health is then provided, respectively. Finally, the major challenges faced by applications of piezoelectricity in orthopedic conditions are thoroughly discussed, along with a critical outlook on future development trends.https://doi.org/10.1002/advs.202410400bone regenerationimplantable and wearable devicesorthopedic medicinepiezoelectric materials |
| spellingShingle | Jingkai Zhang Chang Liu Jun Li Tao Yu Jing Ruan Fan Yang Advanced Piezoelectric Materials, Devices, and Systems for Orthopedic Medicine Advanced Science bone regeneration implantable and wearable devices orthopedic medicine piezoelectric materials |
| title | Advanced Piezoelectric Materials, Devices, and Systems for Orthopedic Medicine |
| title_full | Advanced Piezoelectric Materials, Devices, and Systems for Orthopedic Medicine |
| title_fullStr | Advanced Piezoelectric Materials, Devices, and Systems for Orthopedic Medicine |
| title_full_unstemmed | Advanced Piezoelectric Materials, Devices, and Systems for Orthopedic Medicine |
| title_short | Advanced Piezoelectric Materials, Devices, and Systems for Orthopedic Medicine |
| title_sort | advanced piezoelectric materials devices and systems for orthopedic medicine |
| topic | bone regeneration implantable and wearable devices orthopedic medicine piezoelectric materials |
| url | https://doi.org/10.1002/advs.202410400 |
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