Uji Aktivitas Antidiabetes Kulit Batang Pulai (Alstonia scholaris) melalui Studi In Silico dan Prediksi Profil Farmakokinetika
Alstonia scholaris is a medicinal plant from the Apocynaceae family. Alstonia scholaris stem bark have some medicinal properties, but their effect on antidiabetics mechanisms is still unclear. Alstonia scholaris stem bark have some active compounds such as Echitamine, Beta Sitosterol, Lupeol, Alpha...
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| Format: | Article |
| Language: | English |
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Universitas Islam Malang
2023-01-01
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| Series: | Jurnal Ilmiah Biosaintropis (Bioscience-Tropic) |
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| Online Access: | https://biosaintropis.unisma.ac.id/index.php/biosaintropis/article/view/511 |
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| _version_ | 1849393395012730880 |
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| author | Nugroho Wibisono Yoyon Arif Martino |
| author_facet | Nugroho Wibisono Yoyon Arif Martino |
| author_sort | Nugroho Wibisono |
| collection | DOAJ |
| description | Alstonia scholaris is a medicinal plant from the Apocynaceae family. Alstonia scholaris stem bark have some medicinal properties, but their effect on antidiabetics mechanisms is still unclear. Alstonia scholaris stem bark have some active compounds such as Echitamine, Beta Sitosterol, Lupeol, Alpha Amyrin Acetate, and Betulinic Acid. Present study was designed to find out the best active compounds of A. scholaris as a potential therapeutics agent against diabetes mellitus. This study involved the molecular docking of 3D structures of those active compounds into GLUT-1 receptor protein, visualized their result using Biovia Discovery Studio and pharmacokinetics profile prediction analysis using pkCSM web page. The molecular docking result show that Echitamine (-8,7 kcal/mol) have the lower energy compared to glibenclamide (-9,6 kcal/mol). Based on pkCSM web page, Echitamine were have a good pharmacokinetics profile. |
| format | Article |
| id | doaj-art-a15c5b44801346798a2530b0594de3b4 |
| institution | Kabale University |
| issn | 2338-2805 2460-9455 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Universitas Islam Malang |
| record_format | Article |
| series | Jurnal Ilmiah Biosaintropis (Bioscience-Tropic) |
| spelling | doaj-art-a15c5b44801346798a2530b0594de3b42025-08-20T03:40:25ZengUniversitas Islam MalangJurnal Ilmiah Biosaintropis (Bioscience-Tropic)2338-28052460-94552023-01-0182596410.33474/e-jbst.v8i2.511237Uji Aktivitas Antidiabetes Kulit Batang Pulai (Alstonia scholaris) melalui Studi In Silico dan Prediksi Profil FarmakokinetikaNugroho WibisonoYoyon Arif MartinoAlstonia scholaris is a medicinal plant from the Apocynaceae family. Alstonia scholaris stem bark have some medicinal properties, but their effect on antidiabetics mechanisms is still unclear. Alstonia scholaris stem bark have some active compounds such as Echitamine, Beta Sitosterol, Lupeol, Alpha Amyrin Acetate, and Betulinic Acid. Present study was designed to find out the best active compounds of A. scholaris as a potential therapeutics agent against diabetes mellitus. This study involved the molecular docking of 3D structures of those active compounds into GLUT-1 receptor protein, visualized their result using Biovia Discovery Studio and pharmacokinetics profile prediction analysis using pkCSM web page. The molecular docking result show that Echitamine (-8,7 kcal/mol) have the lower energy compared to glibenclamide (-9,6 kcal/mol). Based on pkCSM web page, Echitamine were have a good pharmacokinetics profile.https://biosaintropis.unisma.ac.id/index.php/biosaintropis/article/view/511alstonia scholarisechitaminealpha amyrin acetatebeta sitosterolin silico |
| spellingShingle | Nugroho Wibisono Yoyon Arif Martino Uji Aktivitas Antidiabetes Kulit Batang Pulai (Alstonia scholaris) melalui Studi In Silico dan Prediksi Profil Farmakokinetika Jurnal Ilmiah Biosaintropis (Bioscience-Tropic) alstonia scholaris echitamine alpha amyrin acetate beta sitosterol in silico |
| title | Uji Aktivitas Antidiabetes Kulit Batang Pulai (Alstonia scholaris) melalui Studi In Silico dan Prediksi Profil Farmakokinetika |
| title_full | Uji Aktivitas Antidiabetes Kulit Batang Pulai (Alstonia scholaris) melalui Studi In Silico dan Prediksi Profil Farmakokinetika |
| title_fullStr | Uji Aktivitas Antidiabetes Kulit Batang Pulai (Alstonia scholaris) melalui Studi In Silico dan Prediksi Profil Farmakokinetika |
| title_full_unstemmed | Uji Aktivitas Antidiabetes Kulit Batang Pulai (Alstonia scholaris) melalui Studi In Silico dan Prediksi Profil Farmakokinetika |
| title_short | Uji Aktivitas Antidiabetes Kulit Batang Pulai (Alstonia scholaris) melalui Studi In Silico dan Prediksi Profil Farmakokinetika |
| title_sort | uji aktivitas antidiabetes kulit batang pulai alstonia scholaris melalui studi in silico dan prediksi profil farmakokinetika |
| topic | alstonia scholaris echitamine alpha amyrin acetate beta sitosterol in silico |
| url | https://biosaintropis.unisma.ac.id/index.php/biosaintropis/article/view/511 |
| work_keys_str_mv | AT nugrohowibisono ujiaktivitasantidiabeteskulitbatangpulaialstoniascholarismelaluistudiinsilicodanprediksiprofilfarmakokinetika AT yoyonarifmartino ujiaktivitasantidiabeteskulitbatangpulaialstoniascholarismelaluistudiinsilicodanprediksiprofilfarmakokinetika |