Toosendanin Induces Hepatotoxicity by Facilitating ALOX5-Mediated Lipid Peroxidation and Sensitizing Cells to Ferroptosis

Toosendanin Induces Hepatotoxicity by Facilitating ALOX5-Mediated Lipid Peroxidation and Sensitizing Cells to Ferroptosis

<b>Background</b>: <i>Fructus Meliae Toosendan</i> (FMT) is a traditional Chinese medicine used to treat ascariasis; however, its reported hepatotoxicity limits its application. Toosendanin (TSN), as a principal active component, is recognized as the primary toxic ingredient...

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Bibliographic Details
Main Authors: Jiajie Ni, Liru Huang, Yifan Tian, Changxin Zhao, Ziyi Zhou, Feihai Shen, Zhiying Huang
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Pharmaceuticals
Subjects:
toosendanin
hepatotoxicity
5-lipoxygenase
lipid peroxidation
ferroptosis
Online Access:https://www.mdpi.com/1424-8247/18/7/1078
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