The Role of PPARγ in Helicobacter pylori Infection and Gastric Carcinogenesis
Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor that is important in many physiological and pathological processes, such as lipid metabolism, insulin sensitivity, inflammation, cell proliferation, and carcinogenesis. Several studies have shown that PPARγ plays an important...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2012/687570 |
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| _version_ | 1832565045342502912 |
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| author | Jong-Min Lee Sung Soo Kim Young-Seok Cho |
| author_facet | Jong-Min Lee Sung Soo Kim Young-Seok Cho |
| author_sort | Jong-Min Lee |
| collection | DOAJ |
| description | Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor that is important in many physiological and pathological processes, such as lipid metabolism, insulin sensitivity, inflammation, cell proliferation, and carcinogenesis. Several studies have shown that PPARγ plays an important role in gastric mucosal injury due to Helicobacter pylori (H. pylori). As H. pylori infection is the main etiologic factor in chronic gastritis and gastric cancer, understanding of the potential roles of PPARγ in H. pylori infection may lead to the development of a therapeutic target. In this paper, the authors discuss the current knowledge on the role of PPARγ in H. pylori infection and its related gastric carcinogenesis. |
| format | Article |
| id | doaj-art-a1355ae4ea9b4c42ab1e8400d7102605 |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-a1355ae4ea9b4c42ab1e8400d71026052025-02-03T01:09:39ZengWileyPPAR Research1687-47571687-47652012-01-01201210.1155/2012/687570687570The Role of PPARγ in Helicobacter pylori Infection and Gastric CarcinogenesisJong-Min Lee0Sung Soo Kim1Young-Seok Cho2Department of Internal Medicine, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Uijeongbu 480717, Republic of KoreaDepartment of Internal Medicine, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Uijeongbu 480717, Republic of KoreaDepartment of Internal Medicine, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Uijeongbu 480717, Republic of KoreaPeroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor that is important in many physiological and pathological processes, such as lipid metabolism, insulin sensitivity, inflammation, cell proliferation, and carcinogenesis. Several studies have shown that PPARγ plays an important role in gastric mucosal injury due to Helicobacter pylori (H. pylori). As H. pylori infection is the main etiologic factor in chronic gastritis and gastric cancer, understanding of the potential roles of PPARγ in H. pylori infection may lead to the development of a therapeutic target. In this paper, the authors discuss the current knowledge on the role of PPARγ in H. pylori infection and its related gastric carcinogenesis.http://dx.doi.org/10.1155/2012/687570 |
| spellingShingle | Jong-Min Lee Sung Soo Kim Young-Seok Cho The Role of PPARγ in Helicobacter pylori Infection and Gastric Carcinogenesis PPAR Research |
| title | The Role of PPARγ in Helicobacter pylori Infection and Gastric Carcinogenesis |
| title_full | The Role of PPARγ in Helicobacter pylori Infection and Gastric Carcinogenesis |
| title_fullStr | The Role of PPARγ in Helicobacter pylori Infection and Gastric Carcinogenesis |
| title_full_unstemmed | The Role of PPARγ in Helicobacter pylori Infection and Gastric Carcinogenesis |
| title_short | The Role of PPARγ in Helicobacter pylori Infection and Gastric Carcinogenesis |
| title_sort | role of pparγ in helicobacter pylori infection and gastric carcinogenesis |
| url | http://dx.doi.org/10.1155/2012/687570 |
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