Nitrate and Nitrite Promote Formation of Tobacco-Specific Nitrosamines via Nitrogen Oxides Intermediates during Postcured Storage under Warm Temperature
Tobacco-specific nitrosamines (TSNAs) are carcinogenic and are present in cured tobacco leaves. This study was designed to elucidate the mechanisms of TSNAs formation under warm temperature storage conditions. Results showed that nitrogen oxides (NOx) were produced from nitrate and nitrite in a shor...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2017/6135215 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832545388095078400 |
|---|---|
| author | Jun Wang Huijuan Yang Hongzhi Shi Jun Zhou Ruoshi Bai Mengyue Zhang Tong Jin |
| author_facet | Jun Wang Huijuan Yang Hongzhi Shi Jun Zhou Ruoshi Bai Mengyue Zhang Tong Jin |
| author_sort | Jun Wang |
| collection | DOAJ |
| description | Tobacco-specific nitrosamines (TSNAs) are carcinogenic and are present in cured tobacco leaves. This study was designed to elucidate the mechanisms of TSNAs formation under warm temperature storage conditions. Results showed that nitrogen oxides (NOx) were produced from nitrate and nitrite in a short period of time under 45°C and then reacted with alkaloids to form TSNAs. Nitrite was more effective than nitrate in promoting TSNAs formation during 45°C storage which may be due to the fact that nitrite can produce a large amount of NOx in comparison with nitrate. Presence of activated carbon effectively inhibited the TSNAs formation because of the adsorption of NOx on the activated carbon. The results indicated that TSNAs are derived from a gas/solid phase nitrosation reaction between NOx and alkaloids. Nitrate and nitrite are major contributors to the formation of TSNAs during warm temperature storage of tobacco. |
| format | Article |
| id | doaj-art-a11e0b3d14a440bc99aa4fe6843acec5 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-a11e0b3d14a440bc99aa4fe6843acec52025-02-03T07:25:57ZengWileyJournal of Chemistry2090-90632090-90712017-01-01201710.1155/2017/61352156135215Nitrate and Nitrite Promote Formation of Tobacco-Specific Nitrosamines via Nitrogen Oxides Intermediates during Postcured Storage under Warm TemperatureJun Wang0Huijuan Yang1Hongzhi Shi2Jun Zhou3Ruoshi Bai4Mengyue Zhang5Tong Jin6Henan Agricultural University, National Tobacco Cultivation & Physiology & Biochemistry Research Center, Zhengzhou 450002, ChinaHenan Agricultural University, National Tobacco Cultivation & Physiology & Biochemistry Research Center, Zhengzhou 450002, ChinaHenan Agricultural University, National Tobacco Cultivation & Physiology & Biochemistry Research Center, Zhengzhou 450002, ChinaBeijing Cigarette Factory, Shanghai Tobacco Group Co. Ltd., Beijing 100024, ChinaBeijing Cigarette Factory, Shanghai Tobacco Group Co. Ltd., Beijing 100024, ChinaHenan Agricultural University, National Tobacco Cultivation & Physiology & Biochemistry Research Center, Zhengzhou 450002, ChinaHenan Agricultural University, National Tobacco Cultivation & Physiology & Biochemistry Research Center, Zhengzhou 450002, ChinaTobacco-specific nitrosamines (TSNAs) are carcinogenic and are present in cured tobacco leaves. This study was designed to elucidate the mechanisms of TSNAs formation under warm temperature storage conditions. Results showed that nitrogen oxides (NOx) were produced from nitrate and nitrite in a short period of time under 45°C and then reacted with alkaloids to form TSNAs. Nitrite was more effective than nitrate in promoting TSNAs formation during 45°C storage which may be due to the fact that nitrite can produce a large amount of NOx in comparison with nitrate. Presence of activated carbon effectively inhibited the TSNAs formation because of the adsorption of NOx on the activated carbon. The results indicated that TSNAs are derived from a gas/solid phase nitrosation reaction between NOx and alkaloids. Nitrate and nitrite are major contributors to the formation of TSNAs during warm temperature storage of tobacco.http://dx.doi.org/10.1155/2017/6135215 |
| spellingShingle | Jun Wang Huijuan Yang Hongzhi Shi Jun Zhou Ruoshi Bai Mengyue Zhang Tong Jin Nitrate and Nitrite Promote Formation of Tobacco-Specific Nitrosamines via Nitrogen Oxides Intermediates during Postcured Storage under Warm Temperature Journal of Chemistry |
| title | Nitrate and Nitrite Promote Formation of Tobacco-Specific Nitrosamines via Nitrogen Oxides Intermediates during Postcured Storage under Warm Temperature |
| title_full | Nitrate and Nitrite Promote Formation of Tobacco-Specific Nitrosamines via Nitrogen Oxides Intermediates during Postcured Storage under Warm Temperature |
| title_fullStr | Nitrate and Nitrite Promote Formation of Tobacco-Specific Nitrosamines via Nitrogen Oxides Intermediates during Postcured Storage under Warm Temperature |
| title_full_unstemmed | Nitrate and Nitrite Promote Formation of Tobacco-Specific Nitrosamines via Nitrogen Oxides Intermediates during Postcured Storage under Warm Temperature |
| title_short | Nitrate and Nitrite Promote Formation of Tobacco-Specific Nitrosamines via Nitrogen Oxides Intermediates during Postcured Storage under Warm Temperature |
| title_sort | nitrate and nitrite promote formation of tobacco specific nitrosamines via nitrogen oxides intermediates during postcured storage under warm temperature |
| url | http://dx.doi.org/10.1155/2017/6135215 |
| work_keys_str_mv | AT junwang nitrateandnitritepromoteformationoftobaccospecificnitrosaminesvianitrogenoxidesintermediatesduringpostcuredstorageunderwarmtemperature AT huijuanyang nitrateandnitritepromoteformationoftobaccospecificnitrosaminesvianitrogenoxidesintermediatesduringpostcuredstorageunderwarmtemperature AT hongzhishi nitrateandnitritepromoteformationoftobaccospecificnitrosaminesvianitrogenoxidesintermediatesduringpostcuredstorageunderwarmtemperature AT junzhou nitrateandnitritepromoteformationoftobaccospecificnitrosaminesvianitrogenoxidesintermediatesduringpostcuredstorageunderwarmtemperature AT ruoshibai nitrateandnitritepromoteformationoftobaccospecificnitrosaminesvianitrogenoxidesintermediatesduringpostcuredstorageunderwarmtemperature AT mengyuezhang nitrateandnitritepromoteformationoftobaccospecificnitrosaminesvianitrogenoxidesintermediatesduringpostcuredstorageunderwarmtemperature AT tongjin nitrateandnitritepromoteformationoftobaccospecificnitrosaminesvianitrogenoxidesintermediatesduringpostcuredstorageunderwarmtemperature |