Influence of Biological Therapeutics, Cytokines, and Disease Activity on Depression in Rheumatoid Arthritis
Purpose. Rheumatoid arthritis (RA) is an often debilitating autoinflammatory disease. Patients with rheumatoid arthritis are often troubled by co-occurring depression or other psychological manifestations. RA patients have a variety of treatment options available, including biologicals that inhibit...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2018/5954897 |
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| author | Margarida Figueiredo-Braga Caleb Cornaby Alice Cortez Miguel Bernardes Georgina Terroso Marta Figueiredo Cristina Dos Santos Mesquita Lúcia Costa Brian D. Poole |
| author_facet | Margarida Figueiredo-Braga Caleb Cornaby Alice Cortez Miguel Bernardes Georgina Terroso Marta Figueiredo Cristina Dos Santos Mesquita Lúcia Costa Brian D. Poole |
| author_sort | Margarida Figueiredo-Braga |
| collection | DOAJ |
| description | Purpose. Rheumatoid arthritis (RA) is an often debilitating autoinflammatory disease. Patients with rheumatoid arthritis are often troubled by co-occurring depression or other psychological manifestations. RA patients have a variety of treatment options available, including biologicals that inhibit cytokines or immune cells. If these cytokines influence the psychological symptoms, then the use of cytokine inhibitors should modulate these symptoms. Methods. A cohort of 209 individuals was recruited. This group included 82 RA patients, 22 healthy subjects, 32 depressed control subjects, and 73 subjects with systemic lupus erythematosus. Of the RA patients, 51% were on a biological therapeutic. ELISA was used to measure cytokine levels. A variety of psychological assessments were used to evaluate depression, anxiety, sleep, fatigue, and relationship status. Clinical values were obtained from medical records. Results. IL-10 concentration was associated with depressive symptoms in the RA patients, healthy controls, and the lupus patients. In the patients with primary depression, depressive symptoms were associated with IL-6 and TNF-alpha. In RA patients, Tocilizumab use was associated with decreased depressive symptoms. 14 RA patients who were not using biologicals began using them by a one-month follow-up. In these patients, there was no significant change to any value except for fatigue. Conclusions. A variety of both biological and social factors influences depressive symptoms in RA. IL-10 and IL-6 are likely to be involved, since IL-10 concentration was associated with depression and Tocilizumab decreased depressive symptoms in the RA patients. The roles of these cytokines are different in RA and lupus, as high IL-10 in RA is associated with increased depressive symptoms, but high IL-10 in the lupus patients is associated with decreased depression. IL-6 was also associated with depressive symptoms in the patients with primary depression. These results strongly indicate that disease activity, including cytokine levels, has a strong impact on depressive symptoms. |
| format | Article |
| id | doaj-art-a11c06f4a72d45f88b0e84660c94bda2 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-a11c06f4a72d45f88b0e84660c94bda22025-02-03T05:44:03ZengWileyJournal of Immunology Research2314-88612314-71562018-01-01201810.1155/2018/59548975954897Influence of Biological Therapeutics, Cytokines, and Disease Activity on Depression in Rheumatoid ArthritisMargarida Figueiredo-Braga0Caleb Cornaby1Alice Cortez2Miguel Bernardes3Georgina Terroso4Marta Figueiredo5Cristina Dos Santos Mesquita6Lúcia Costa7Brian D. Poole8Medical Psychology Unit, Department of Clinical Neurosciences and Mental Health, Faculty of Medicine, University of Porto, Porto, PortugalDepartment of Microbiology and Molecular Biology, Brigham Young University, Provo, UT, USALaboratorio Nobre, Faculty of Medicine, University of Porto, Porto, PortugalRheumatology Department, Hospital of São João EPE, Porto, PortugalRheumatology Department, Hospital of São João EPE, Porto, PortugalMedical Psychology Unit, Department of Clinical Neurosciences and Mental Health, Faculty of Medicine, University of Porto, Porto, PortugalDepartamento de Psicologia Aplicada (DPA), Universidade do Minho, Braga, Minho, PortugalRheumatology Department, Hospital of São João EPE, Porto, PortugalDepartment of Microbiology and Molecular Biology, Brigham Young University, Provo, UT, USAPurpose. Rheumatoid arthritis (RA) is an often debilitating autoinflammatory disease. Patients with rheumatoid arthritis are often troubled by co-occurring depression or other psychological manifestations. RA patients have a variety of treatment options available, including biologicals that inhibit cytokines or immune cells. If these cytokines influence the psychological symptoms, then the use of cytokine inhibitors should modulate these symptoms. Methods. A cohort of 209 individuals was recruited. This group included 82 RA patients, 22 healthy subjects, 32 depressed control subjects, and 73 subjects with systemic lupus erythematosus. Of the RA patients, 51% were on a biological therapeutic. ELISA was used to measure cytokine levels. A variety of psychological assessments were used to evaluate depression, anxiety, sleep, fatigue, and relationship status. Clinical values were obtained from medical records. Results. IL-10 concentration was associated with depressive symptoms in the RA patients, healthy controls, and the lupus patients. In the patients with primary depression, depressive symptoms were associated with IL-6 and TNF-alpha. In RA patients, Tocilizumab use was associated with decreased depressive symptoms. 14 RA patients who were not using biologicals began using them by a one-month follow-up. In these patients, there was no significant change to any value except for fatigue. Conclusions. A variety of both biological and social factors influences depressive symptoms in RA. IL-10 and IL-6 are likely to be involved, since IL-10 concentration was associated with depression and Tocilizumab decreased depressive symptoms in the RA patients. The roles of these cytokines are different in RA and lupus, as high IL-10 in RA is associated with increased depressive symptoms, but high IL-10 in the lupus patients is associated with decreased depression. IL-6 was also associated with depressive symptoms in the patients with primary depression. These results strongly indicate that disease activity, including cytokine levels, has a strong impact on depressive symptoms.http://dx.doi.org/10.1155/2018/5954897 |
| spellingShingle | Margarida Figueiredo-Braga Caleb Cornaby Alice Cortez Miguel Bernardes Georgina Terroso Marta Figueiredo Cristina Dos Santos Mesquita Lúcia Costa Brian D. Poole Influence of Biological Therapeutics, Cytokines, and Disease Activity on Depression in Rheumatoid Arthritis Journal of Immunology Research |
| title | Influence of Biological Therapeutics, Cytokines, and Disease Activity on Depression in Rheumatoid Arthritis |
| title_full | Influence of Biological Therapeutics, Cytokines, and Disease Activity on Depression in Rheumatoid Arthritis |
| title_fullStr | Influence of Biological Therapeutics, Cytokines, and Disease Activity on Depression in Rheumatoid Arthritis |
| title_full_unstemmed | Influence of Biological Therapeutics, Cytokines, and Disease Activity on Depression in Rheumatoid Arthritis |
| title_short | Influence of Biological Therapeutics, Cytokines, and Disease Activity on Depression in Rheumatoid Arthritis |
| title_sort | influence of biological therapeutics cytokines and disease activity on depression in rheumatoid arthritis |
| url | http://dx.doi.org/10.1155/2018/5954897 |
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