The Dual Role of HLA-G in Cancer
We here review the current data on the role of HLA-G in cancer based on recent findings of an unexpected antitumor activity of HLA-G in hematological malignancies. For the past decade, HLA-G has been described as a tumor-escape mechanism favoring cancer progression, and blocking strategies have been...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2014/359748 |
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| author | Nathalie Rouas-Freiss Philippe Moreau Joel LeMaoult Edgardo D. Carosella |
| author_facet | Nathalie Rouas-Freiss Philippe Moreau Joel LeMaoult Edgardo D. Carosella |
| author_sort | Nathalie Rouas-Freiss |
| collection | DOAJ |
| description | We here review the current data on the role of HLA-G in cancer based on recent findings of an unexpected antitumor activity of HLA-G in hematological malignancies. For the past decade, HLA-G has been described as a tumor-escape mechanism favoring cancer progression, and blocking strategies have been proposed to counteract it. Aside from these numerous studies on solid tumors, recent data showed that HLA-G inhibits the proliferation of malignant B cells due to the interaction between HLA-G and its receptor ILT2, which mediates negative signaling on B cell proliferation. These results led to the conjecture that, according to the malignant cell type, HLA-G should be blocked or conversely induced to counteract tumor progression. In this context, we will here present (i) the dual role of HLA-G in solid and liquid tumors with special emphasis on (ii) the HLA-G active structures and their related ILT2 and ILT4 receptors and (iii) the current knowledge on regulatory mechanisms of HLA-G expression in tumors. |
| format | Article |
| id | doaj-art-a1101821b9fb46008bcc2499fbca4e3d |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-a1101821b9fb46008bcc2499fbca4e3d2025-02-03T01:21:09ZengWileyJournal of Immunology Research2314-88612314-71562014-01-01201410.1155/2014/359748359748The Dual Role of HLA-G in CancerNathalie Rouas-Freiss0Philippe Moreau1Joel LeMaoult2Edgardo D. Carosella3CEA, Institut des Maladies Emergentes et des Therapies Innovantes (IMETI), Service de Recherche en Hemato-Immunologie (SRHI), Hopital Saint-Louis, 75010 Paris, FranceCEA, Institut des Maladies Emergentes et des Therapies Innovantes (IMETI), Service de Recherche en Hemato-Immunologie (SRHI), Hopital Saint-Louis, 75010 Paris, FranceCEA, Institut des Maladies Emergentes et des Therapies Innovantes (IMETI), Service de Recherche en Hemato-Immunologie (SRHI), Hopital Saint-Louis, 75010 Paris, FranceCEA, Institut des Maladies Emergentes et des Therapies Innovantes (IMETI), Service de Recherche en Hemato-Immunologie (SRHI), Hopital Saint-Louis, 75010 Paris, FranceWe here review the current data on the role of HLA-G in cancer based on recent findings of an unexpected antitumor activity of HLA-G in hematological malignancies. For the past decade, HLA-G has been described as a tumor-escape mechanism favoring cancer progression, and blocking strategies have been proposed to counteract it. Aside from these numerous studies on solid tumors, recent data showed that HLA-G inhibits the proliferation of malignant B cells due to the interaction between HLA-G and its receptor ILT2, which mediates negative signaling on B cell proliferation. These results led to the conjecture that, according to the malignant cell type, HLA-G should be blocked or conversely induced to counteract tumor progression. In this context, we will here present (i) the dual role of HLA-G in solid and liquid tumors with special emphasis on (ii) the HLA-G active structures and their related ILT2 and ILT4 receptors and (iii) the current knowledge on regulatory mechanisms of HLA-G expression in tumors.http://dx.doi.org/10.1155/2014/359748 |
| spellingShingle | Nathalie Rouas-Freiss Philippe Moreau Joel LeMaoult Edgardo D. Carosella The Dual Role of HLA-G in Cancer Journal of Immunology Research |
| title | The Dual Role of HLA-G in Cancer |
| title_full | The Dual Role of HLA-G in Cancer |
| title_fullStr | The Dual Role of HLA-G in Cancer |
| title_full_unstemmed | The Dual Role of HLA-G in Cancer |
| title_short | The Dual Role of HLA-G in Cancer |
| title_sort | dual role of hla g in cancer |
| url | http://dx.doi.org/10.1155/2014/359748 |
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