Rare Case of Gut-associated Lymphoid Tissue Carcinoma in the Sigmoid Colon of a Very Elderly Patient: A Case Report
Colorectal cancer with gut-associated lymphoid tissue (GALT) carcinoma histopathology is particularly rare in very elderly patients. GALT is characterized by submucosal localization and prominent lymphoid infiltration with germinal center formation within tumor-infiltrating lymphocytes. This study a...
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| Format: | Article |
| Language: | English |
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The Japan Society of Coloproctology
2025-01-01
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| Series: | Journal of the Anus, Rectum and Colon |
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| Online Access: | https://www.jstage.jst.go.jp/article/jarc/9/1/9_2024-054/_pdf/-char/en |
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| author | Kou Kanesada Kazuhiko Yoshimatsu Yoshitomo Ito Shuya Yano Masaaki Hori Masaharu Higashida Toshimasa Okada Shunji Endo Yoshinori Fujiwara Yasuto Fujimoto Tatsushi Shiomi Tomio Ueno |
| author_facet | Kou Kanesada Kazuhiko Yoshimatsu Yoshitomo Ito Shuya Yano Masaaki Hori Masaharu Higashida Toshimasa Okada Shunji Endo Yoshinori Fujiwara Yasuto Fujimoto Tatsushi Shiomi Tomio Ueno |
| author_sort | Kou Kanesada |
| collection | DOAJ |
| description | Colorectal cancer with gut-associated lymphoid tissue (GALT) carcinoma histopathology is particularly rare in very elderly patients. GALT is characterized by submucosal localization and prominent lymphoid infiltration with germinal center formation within tumor-infiltrating lymphocytes. This study aims to report a case of colorectal cancer with GALT carcinoma histopathology in a very elderly patient and to provide a comprehensive literature review. In this case, a 90-year-old female presented with an irregularly elevated tumor in the sigmoid colon, diagnosed via colonoscopy. Computed tomography revealed no lymph node or distant metastases. The patient underwent laparoscopy-assisted sigmoid colon resection with D3 dissection. Histopathological examination revealed well-differentiated adenocarcinoma in the submucosal layer with partial invasion into the muscle layer. Lymphocytes, along with lymph follicles, proliferated compressively in the stroma surrounding the tumor glands. Immunohistochemical analysis showed lost expression of mismatch repair proteins, MLH1 and PMS2, consistent with the tumor immunohistochemistry profile. B cells (CD20- and CD79a-positive) were generally distributed in and around the lymph follicles, while T cells (CD3-positive) were primarily located between the lymph follicles. This case highlights the rare histopathology of GALT carcinoma in colorectal cancer and underscores the importance of considering such diagnoses in elderly patients with colorectal tumors. |
| format | Article |
| id | doaj-art-a10cf8e44119403cb4902cd947b1a366 |
| institution | Kabale University |
| issn | 2432-3853 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | The Japan Society of Coloproctology |
| record_format | Article |
| series | Journal of the Anus, Rectum and Colon |
| spelling | doaj-art-a10cf8e44119403cb4902cd947b1a3662025-01-27T10:02:41ZengThe Japan Society of ColoproctologyJournal of the Anus, Rectum and Colon2432-38532025-01-019115616110.23922/jarc.2024-0542024-054Rare Case of Gut-associated Lymphoid Tissue Carcinoma in the Sigmoid Colon of a Very Elderly Patient: A Case ReportKou Kanesada0Kazuhiko Yoshimatsu1Yoshitomo Ito2Shuya Yano3Masaaki Hori4Masaharu Higashida5Toshimasa Okada6Shunji Endo7Yoshinori Fujiwara8Yasuto Fujimoto9Tatsushi Shiomi10Tomio Ueno11Department of Digestive Surgery, Kawasaki Medical SchoolDepartment of Digestive Surgery, Kawasaki Medical SchoolDepartment of Digestive Surgery, Kawasaki Medical SchoolDepartment of Digestive Surgery, Kawasaki Medical SchoolDepartment of Digestive Surgery, Kawasaki Medical SchoolDepartment of Digestive Surgery, Kawasaki Medical SchoolDepartment of Digestive Surgery, Kawasaki Medical SchoolDepartment of Digestive Surgery, Kawasaki Medical SchoolDepartment of Digestive Surgery, Kawasaki Medical SchoolDepartment of Pathology, Kawasaki Medical SchoolDepartment of Pathology, Kawasaki Medical SchoolDepartment of Digestive Surgery, Kawasaki Medical SchoolColorectal cancer with gut-associated lymphoid tissue (GALT) carcinoma histopathology is particularly rare in very elderly patients. GALT is characterized by submucosal localization and prominent lymphoid infiltration with germinal center formation within tumor-infiltrating lymphocytes. This study aims to report a case of colorectal cancer with GALT carcinoma histopathology in a very elderly patient and to provide a comprehensive literature review. In this case, a 90-year-old female presented with an irregularly elevated tumor in the sigmoid colon, diagnosed via colonoscopy. Computed tomography revealed no lymph node or distant metastases. The patient underwent laparoscopy-assisted sigmoid colon resection with D3 dissection. Histopathological examination revealed well-differentiated adenocarcinoma in the submucosal layer with partial invasion into the muscle layer. Lymphocytes, along with lymph follicles, proliferated compressively in the stroma surrounding the tumor glands. Immunohistochemical analysis showed lost expression of mismatch repair proteins, MLH1 and PMS2, consistent with the tumor immunohistochemistry profile. B cells (CD20- and CD79a-positive) were generally distributed in and around the lymph follicles, while T cells (CD3-positive) were primarily located between the lymph follicles. This case highlights the rare histopathology of GALT carcinoma in colorectal cancer and underscores the importance of considering such diagnoses in elderly patients with colorectal tumors.https://www.jstage.jst.go.jp/article/jarc/9/1/9_2024-054/_pdf/-char/engut-associated lymphoid tissue carcinomadome-type carcinomacolon cancer |
| spellingShingle | Kou Kanesada Kazuhiko Yoshimatsu Yoshitomo Ito Shuya Yano Masaaki Hori Masaharu Higashida Toshimasa Okada Shunji Endo Yoshinori Fujiwara Yasuto Fujimoto Tatsushi Shiomi Tomio Ueno Rare Case of Gut-associated Lymphoid Tissue Carcinoma in the Sigmoid Colon of a Very Elderly Patient: A Case Report Journal of the Anus, Rectum and Colon gut-associated lymphoid tissue carcinoma dome-type carcinoma colon cancer |
| title | Rare Case of Gut-associated Lymphoid Tissue Carcinoma in the Sigmoid Colon of a Very Elderly Patient: A Case Report |
| title_full | Rare Case of Gut-associated Lymphoid Tissue Carcinoma in the Sigmoid Colon of a Very Elderly Patient: A Case Report |
| title_fullStr | Rare Case of Gut-associated Lymphoid Tissue Carcinoma in the Sigmoid Colon of a Very Elderly Patient: A Case Report |
| title_full_unstemmed | Rare Case of Gut-associated Lymphoid Tissue Carcinoma in the Sigmoid Colon of a Very Elderly Patient: A Case Report |
| title_short | Rare Case of Gut-associated Lymphoid Tissue Carcinoma in the Sigmoid Colon of a Very Elderly Patient: A Case Report |
| title_sort | rare case of gut associated lymphoid tissue carcinoma in the sigmoid colon of a very elderly patient a case report |
| topic | gut-associated lymphoid tissue carcinoma dome-type carcinoma colon cancer |
| url | https://www.jstage.jst.go.jp/article/jarc/9/1/9_2024-054/_pdf/-char/en |
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