MicroRNA Profiling in Cartilage Ageing
Osteoarthritis (OA) is the most common age-related joint disorder in man. MicroRNAs (miRNA), a class of small noncoding RNAs, are potential therapeutic targets for regulating molecular mechanisms in both disease and ageing. Whilst there is an increasing amount of research on the roles of miRNAs in a...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
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| Series: | International Journal of Genomics |
| Online Access: | http://dx.doi.org/10.1155/2017/2713725 |
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| _version_ | 1832564557995835392 |
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| author | Panagiotis Balaskas Katarzyna Goljanek-Whysall Peter Clegg Yongxiang Fang Andy Cremers Pieter Emans Tim Welting Mandy Peffers |
| author_facet | Panagiotis Balaskas Katarzyna Goljanek-Whysall Peter Clegg Yongxiang Fang Andy Cremers Pieter Emans Tim Welting Mandy Peffers |
| author_sort | Panagiotis Balaskas |
| collection | DOAJ |
| description | Osteoarthritis (OA) is the most common age-related joint disorder in man. MicroRNAs (miRNA), a class of small noncoding RNAs, are potential therapeutic targets for regulating molecular mechanisms in both disease and ageing. Whilst there is an increasing amount of research on the roles of miRNAs in ageing, there has been scant research on age-related changes in miRNA in a cartilage. We undertook a microarray study on young and old human cartilages. Findings were validated in an independent cohort. Contrasts between these samples identified twenty differentially expressed miRNAs in a cartilage from old donors, derived from an OA environment which clustered based on OA severity. We identified a number of recognised and novel miRNAs changing in cartilage ageing and OA including miR-126: a potential new candidate with a role in OA pathogenesis. These analyses represent important candidates that have the potential as cartilage ageing and OA biomarkers and therapeutic targets. |
| format | Article |
| id | doaj-art-a10b242ff1854d83a52ab6df8268a097 |
| institution | Kabale University |
| issn | 2314-436X 2314-4378 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Genomics |
| spelling | doaj-art-a10b242ff1854d83a52ab6df8268a0972025-02-03T01:10:43ZengWileyInternational Journal of Genomics2314-436X2314-43782017-01-01201710.1155/2017/27137252713725MicroRNA Profiling in Cartilage AgeingPanagiotis Balaskas0Katarzyna Goljanek-Whysall1Peter Clegg2Yongxiang Fang3Andy Cremers4Pieter Emans5Tim Welting6Mandy Peffers7Institute of Ageing and Chronic Disease, William Henry Duncan Building, 6 West Derby Street, Liverpool L7 8TX, UKInstitute of Ageing and Chronic Disease, William Henry Duncan Building, 6 West Derby Street, Liverpool L7 8TX, UKInstitute of Ageing and Chronic Disease, William Henry Duncan Building, 6 West Derby Street, Liverpool L7 8TX, UKCentre for Genomic Research, Institute of Integrative Biology, Biosciences Building, Crown Street, University of Liverpool, Liverpool L69 7ZB, UKDepartment of Orthopaedic Surgery, Maastricht University Medical Centre, 6202 AZ Maastricht, NetherlandsDepartment of Orthopaedic Surgery, Maastricht University Medical Centre, 6202 AZ Maastricht, NetherlandsDepartment of Orthopaedic Surgery, Maastricht University Medical Centre, 6202 AZ Maastricht, NetherlandsInstitute of Ageing and Chronic Disease, William Henry Duncan Building, 6 West Derby Street, Liverpool L7 8TX, UKOsteoarthritis (OA) is the most common age-related joint disorder in man. MicroRNAs (miRNA), a class of small noncoding RNAs, are potential therapeutic targets for regulating molecular mechanisms in both disease and ageing. Whilst there is an increasing amount of research on the roles of miRNAs in ageing, there has been scant research on age-related changes in miRNA in a cartilage. We undertook a microarray study on young and old human cartilages. Findings were validated in an independent cohort. Contrasts between these samples identified twenty differentially expressed miRNAs in a cartilage from old donors, derived from an OA environment which clustered based on OA severity. We identified a number of recognised and novel miRNAs changing in cartilage ageing and OA including miR-126: a potential new candidate with a role in OA pathogenesis. These analyses represent important candidates that have the potential as cartilage ageing and OA biomarkers and therapeutic targets.http://dx.doi.org/10.1155/2017/2713725 |
| spellingShingle | Panagiotis Balaskas Katarzyna Goljanek-Whysall Peter Clegg Yongxiang Fang Andy Cremers Pieter Emans Tim Welting Mandy Peffers MicroRNA Profiling in Cartilage Ageing International Journal of Genomics |
| title | MicroRNA Profiling in Cartilage Ageing |
| title_full | MicroRNA Profiling in Cartilage Ageing |
| title_fullStr | MicroRNA Profiling in Cartilage Ageing |
| title_full_unstemmed | MicroRNA Profiling in Cartilage Ageing |
| title_short | MicroRNA Profiling in Cartilage Ageing |
| title_sort | microrna profiling in cartilage ageing |
| url | http://dx.doi.org/10.1155/2017/2713725 |
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